Long Term Dietary Effects of Soy Protein in Cebus Monkeys

James P. Harwood; Benjamin A. Jackson; Nancie McCabe

Long Term Dietary Effects of Soy Protein in Cebus Monkeys

In: Recent advances of research in antinutritional factors in legume seeds

Authors:

James P. Harwood

James P. Harwood 1. Present address: Building 31/5C-12, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA

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Benjamin A. Jackson

Benjamin A. Jackson Division of Nutrition, Food and Drug Administration, Washington, DC, 20204, USA

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Nancie McCabe

Nancie McCabe Division of Nutrition, Food and Drug Administration, Washington, DC, 20204, USA

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Type:: Chapter

Pages:: 95–98

DOI:: https://doi.org/10.1163/9789004684690_018

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Summary

Since adverse pancreatic effects have been observed in a variety of rodents when fed diets containing soybean trypsin inhibitor, this study was designed to evaluate whether long-term exposure of primates to such diets has any adverse nutritional impact. Twenty-six Cebus monkeys were supplied from infancy with semisynthetic diets containing as their sole protein source casein, lactalbumin, soy isolate or soy concentrate. Each batch of the four diets was assayed for trypsin inhibitor content. After three years a pancreatic biopsy was obtained by surgical section and examined histologically. No evidence of pancreatic hypertrophy or hyperplasia was noted. After five years of continuous exposure to the diets (about 25% of the estimated lifespan) a full autopsy was performed together with hematology and blood chemistry. Examination of major organ systems at autopsy and histological examination of the tissues revealed no adverse pathology related to ingestion of trypsin inhibitor. Overall health, body weight and blood parameters were comparable between the groups. Under these experimental conditions, the findings suggest that long-term exposure (five years) of the Cebus monkey to trypsin inhibitor-containing diets does not cause any adverse pancreatic effects, and that primates may not therefore be susceptible to the adverse effects observed when such diets are fed to rodents.

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Recent advances of research in antinutritional factors in legume seeds

Proceedings of the first international workshop on ANF in legume seeds, Wageningen 23-25 nov. '88

E-Book ISBN:: 9789004684690

Publisher:: Wageningen Academic

Print Publication Date:: 01 Jan 1989

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- Life Sciences

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Long Term Dietary Effects of Soy Protein in Cebus Monkeys

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Recent advances of research in antinutritional factors in legume seeds

Proceedings of the first international workshop on ANF in legume seeds, Wageningen 23-25 nov. '88

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