Stimulation of Polyamine Synthesis and Growth of the Small Intestine by Dietary Kidney Bean Lectin

S. Bardocz; G. Grant; D.S. Brown; A. Pusztai

Stimulation of Polyamine Synthesis and Growth of the Small Intestine by Dietary Kidney Bean Lectin

in Recent advances of research in antinutritional factors in legume seeds

Autor:innen:

S. Bardocz

S. Bardocz The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, Scotland, U.K.

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G. Grant

G. Grant The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, Scotland, U.K.

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D.S. Brown

D.S. Brown The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, Scotland, U.K.

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A. Pusztai

A. Pusztai The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, Scotland, U.K.

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Art:: Kapitel

Seiten:: 39–42

DOI:: https://doi.org/10.1163/9789004684690_008

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Summary

Phaseolus vulgaris lectin (PHA)-induced hyperplastic growth of the small intestine was dependent on a simultaneously occurring increase in tissue polyamine concentration. However, most of the increase in the amounts of polyamines was not due to local synthesis via ornithine decarboxylase (ODC) but to a PHA-induced increase in the uptake of the polyamines needed for cellular proliferation. The main source of polyamines for the gut was the blood, with smaller amounts derived from food. However, polyamine concentration in circulating blood is usually very low, therefore, most of the polyamines needed for the PHA-induced cellular proliferation in the small intestine must ultimately derive from internal organs and/or tissues of the body. Neither the source nor the mechanism of polyamine release into blood circulation, due to the initial stimulus by dietary PHA reaching the small intestine, is known. All the same, stimulation of wastefully increased protein, DNA and RNA syntheses, high metabolic activity and cell turnover rates in brush border cells through a polyamine-dependent mechanism contributes to and exacerbates the nutritional toxicity of dietary PHA.

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Recent advances of research in antinutritional factors in legume seeds

Proceedings of the first international workshop on ANF in legume seeds, Wageningen 23-25 nov. '88

ISBN:: 9789004684690

Verleger:: Wageningen Academic

Print-Publikationsdatum:: 01 Jan 1989

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Stimulation of Polyamine Synthesis and Growth of the Small Intestine by Dietary Kidney Bean Lectin

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Recent advances of research in antinutritional factors in legume seeds

Proceedings of the first international workshop on ANF in legume seeds, Wageningen 23-25 nov. '88

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