Resolving the enigma of embryonic diapause, a forty-year scientific journey

B.D. Murphy

Resolving the enigma of embryonic diapause, a forty-year scientific journey

In: Proceedings of the Xth International Scientific Congress in Fur Animal Production

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B.D. Murphy

B.D. Murphy Centre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 7C6, Canada; bruce.d.murphy@umontreal.ca

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Type:: Chapter

Pages:: 223–228

DOI:: https://doi.org/10.3920/9789086867608_035

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Dar Hadith al Hassania

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Embryonic diapause is an evolutionary strategy by which a reversible arrest in embryo development occurs. In its two forms, facultative and obligate, it assures that offspring are born when optimal maternal and environmental conditions are present to ensure maximal survival. We have explored obligate delayed implantation in the mink over four decades, first by evaluation of the environmental regulation, then by determination of the pituitary factors that maintain diapause and provoke implantation followed by evaluation of the ovarian contribution to the process. As the uterine environment is the proximal regulator of diapause, we employed a strategy of global gene analysis to discover differentially expressed pathways during embryo arrest and reactivation. These trials revealed that the synthesis of polyamines was increased in the uterus with reactivation of the embryo in vivo. Subsequent experiments demonstrated that the polyamine, putrescine, was capable of inducing escape of the embryo from obligate diapause, providing strong evidence that the paucity of polyamines induces developmental arrest and reactivation is coupled to renewed uterine and/embryonic synthesis of these polycations.

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Proceedings of the Xth International Scientific Congress in Fur Animal Production

Scientifur Volume 36 (3/4)

E-Book ISBN:: 9789086867608

Publisher:: Wageningen Academic

Print Publication Date:: 30 Oct 2012

Subjects
- Life Sciences
  - General
  - Animal & Veterinary

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Resolving the enigma of embryonic diapause, a forty-year scientific journey

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Proceedings of the Xth International Scientific Congress in Fur Animal Production

Scientifur Volume 36 (3/4)

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