In vivo MALDI-TOF markers for early detection of Aleutian disease (AD) among the AD virus infected mink

A. Cepica; A. Zargar; B. Mohamed; I. Iwamoto

In vivo MALDI-TOF markers for early detection of Aleutian disease (AD) among the AD virus infected mink

In: Proceedings of the Xth International Scientific Congress in Fur Animal Production

Authors:

A. Cepica

A. Cepica ¹Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave., Charlottetown, P.E.I., Canada, C1A 4P3

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A. Zargar

A. Zargar ¹Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave., Charlottetown, P.E.I., Canada, C1A 4P3
²Department of Aquatic Animal Health, Faculty of Veterinary Medicine University of Tehran Qareeb Str., Azadi Ave., Tehran, Iran; acepica@upei.ca

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B. Mohamed

B. Mohamed ¹Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave., Charlottetown, P.E.I., Canada, C1A 4P3

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I. Iwamoto

I. Iwamoto ¹Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave., Charlottetown, P.E.I., Canada, C1A 4P3

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Type:: Chapter

Pages:: 134–145

DOI:: https://doi.org/10.3920/9789086867608_021

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Dar Hadith al Hassania

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A significant proportion of infected mink of non-Aleutian genotype naturally resists progression to immune complex disease. The nature of the AD resistance is presumably genetic. While hyper-gammaglubulinemia can be insensitively detected by an iodine test, more sensitive diagnosis of hyper-γ globulinemia and of other serum protein parameters associated with an immune-complex disease is currently cost prohibitive, time consuming, and laborious. Thus, practical, cost effective, sensitive, and high throughput tests for in vivo markers of disease vs. health in AD virus infected animals are currently not available. Such markers could have potential practical use in selection of AD virus infected animals for disease resistance. In this study, initially, parameters for serum protein MALDI-TOF serum analysis were established, and subsequently serum proteins of infected mink (CIEP positive) and mink from ADV uninfected farms were profiled by MALDI-TOF spectrometry. We determined the albumin-γ globulin (A/γ G) ratios and albumin-C reactive protein (A/C) ratios associated with health and disease, and furthermore we identified a 76Kda protein, associated exclusively with disease, i.e. with pathological A/ γ G ratio. We concluded that MALDI-TOF profiles of CIPE positive animals provide practical and cost effective tool for selection of breeders for AD resistant phenotype, which could in turn facilitate ‘on farm resistance breeding programs’

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Proceedings of the Xth International Scientific Congress in Fur Animal Production

Scientifur Volume 36 (3/4)

E-Book ISBN:: 9789086867608

Publisher:: Wageningen Academic

Print Publication Date:: 30 Oct 2012

Subjects
- Life Sciences
  - General
  - Animal & Veterinary

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In vivo MALDI-TOF markers for early detection of Aleutian disease (AD) among the AD virus infected mink

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Proceedings of the Xth International Scientific Congress in Fur Animal Production

Scientifur Volume 36 (3/4)

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