Elimination of antibiotic resistance in Pseudomonas aeruginosa UCP/WFCC 1567 by cadmium treatment

J.C. Vilar Júnior; L.M.L. Acioly; M.V. Leite; A.A. Barbosa da Silveira; A.E. Nascimento; G.M. Campos-Takaki

Elimination of antibiotic resistance in Pseudomonas aeruginosa UCP/WFCC 1567 by cadmium treatment

于Industrial, medical and environmental applications of microorganisms

著者：

J.C. Vilar Júnior

J.C. Vilar Júnior ¹Doctorate Biotechnology, Northeast Biotechnology Network, RENORBIO, Federal Rural University of Pernambuco, UFRPE, 52171-900 Recife, Brazil; carlos_vilar@hotmail.com
⁴Nucleius of Research in Environmental Sciences and Biotechnology (NPCIAMB), 50050590 Recife, PE, Brazil

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L.M.L. Acioly

L.M.L. Acioly ²Doctorate in Biological Sciences, Federal University of Pernambuco, UFPE, 50670-901 Recife, Brazil
⁴Nucleius of Research in Environmental Sciences and Biotechnology (NPCIAMB), 50050590 Recife, PE, Brazil

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M.V. Leite

M.V. Leite ¹Doctorate Biotechnology, Northeast Biotechnology Network, RENORBIO, Federal Rural University of Pernambuco, UFRPE, 52171-900 Recife, Brazil; carlos_vilar@hotmail.com
⁴Nucleius of Research in Environmental Sciences and Biotechnology (NPCIAMB), 50050590 Recife, PE, Brazil

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A.A. Barbosa da Silveira

A.A. Barbosa da Silveira ³Doctor in Biotechnology, Guararapes Faculty, 54400-160 Recife, Brazil

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A.E. Nascimento

A.E. Nascimento ⁴Nucleius of Research in Environmental Sciences and Biotechnology (NPCIAMB), 50050590 Recife, PE, Brazil

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, and

G.M. Campos-Takaki

G.M. Campos-Takaki ¹Doctorate Biotechnology, Northeast Biotechnology Network, RENORBIO, Federal Rural University of Pernambuco, UFRPE, 52171-900 Recife, Brazil; carlos_vilar@hotmail.com
⁴Nucleius of Research in Environmental Sciences and Biotechnology (NPCIAMB), 50050590 Recife, PE, Brazil

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类型:: 章节

Page Range:: 104–108

DOI:: https://doi.org/10.3920/9789086867950_017

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Pseudomonas aeruginosa is an aerobic bacilli, gram-negative, that can cause nosocomial infections, especially in immune compromised patients. The virulence factors are capable to inactivating the immune system and their infections are particularly problematic as due to intrinsic resistance to multiple classes of antibiotics, or acquiring adaptive resistance during treatment in course. A variety of compounds such as acridine dyes, ethidium bromide, rifampicin, bis ammonium salt, metals such as silver, and more recently, thioridazine a phenothiazine inhibitors like antibiotics B subunit of DNA gyrase, novobiocin and coumermicine have been reported to eliminate plasmid resistant. Some reports described the plasmids by curing inhibitors of DNA gyrase subunit in strains of P. aeruginosa. In this work was used clinical P. aeruginosa strain multiresistant (UCP/WFCC 1567) to evaluate the eliminating the antibiotic resistance using the treatment with heavy metal cadmium, until extreme saturation of metal (52 μg/ml) by acclimatization process. The profile of susceptibility to antibiotics of the strain was carried out by Kirb Bauer diffusion method comparing the wild type strain and acclimatized strain using Luria Bertani medium added glucose and cadmium (32 μg/ml). Subsequently, a new acclimatization process of P. aeruginosa was done using cadmium 52 μg/ml, followed determination of new profile of susceptibility to antibiotics. The initial results indicated 84.61% of effective eliminating plasmidial resistance using 32 μg/ml of cadmium treatment. However, the second acclimatization process with 52 μg/ml of cadmium the elimination was 92.30%. These results obtained suggest the potential of the treatment with heavy metal cadmium to plasmidial elimination process.

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Industrial, medical and environmental applications of microorganisms

Current status and trends

ISBN:: 9789086867950

出版社:: Wageningen Academic

印刷出版日期:: 01 Nov 2014

Subjects
- Life Sciences

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Elimination of antibiotic resistance in Pseudomonas aeruginosa UCP/WFCC 1567 by cadmium treatment

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Industrial, medical and environmental applications of microorganisms

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