Response of rhlf-transgenic dairy cows to expermentally induced escherichia coli mastitis

Paula Hyvönen; Leena Suojala; Toomas Orro; Satu Pyörälä

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Response of rhlf-transgenic dairy cows to expermentally induced escherichia coli mastitis

于Mastitis in dairy production

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Paula Hyvönen

Paula Hyvönen

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Leena Suojala

Leena Suojala

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Toomas Orro

Toomas Orro

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Satu Pyörälä

Satu Pyörälä

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类型:: 章节

Page Range:: 196–201

DOI:: https://doi.org/10.3920/9789086865505_026

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Lactoferrin (Lf), an antibacterial glycoprotein, contributes to the defence mechanisms of the mammary gland. Generating recombinant human Lf (rhLf) transgenic dairy cows expressing high concentrations of rhLf (mean 2.9 mg/ml) in the milk, could increase their resistance to intramammary infections. The aim of this study was to investigate the response of rhLf-transgenic dairy cows to experimental Escherichia coli mastitis. Seven first-calving, early-lactating Holstein-Friesian cows expressing rhLf in their milk and six normal cows were used. One udder quarter of each cow was inoculated with 1700 cfu of E. coli in vitro susceptible to Lf. Clinical signs were recorded during the experimental period, and human and bovine Lf concentrations, bacterial counts and SCC were determined from milk and acute phase proteins from serum and milk. All cows became infected and developed clinical mastitis, which was mostly moderate in transgenic cows but more severe in control cows. Systemic signs, serum amyloid A, haptoglobin, cortisol and clinical recovery rate significantly differed between the groups. We conclude that it is possible to augment the nonspecific defence mechanism in the mammary gland by the endotoxin neutralizing effect of Lf, and to decrease the severity of the inflammation and thus to enhance the recovery from E. coli mastitis.

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Mastitis in dairy production

Current knowledge and future solutions

ISBN:: 9789086865505

出版社:: Wageningen Academic

印刷出版日期:: 24 Oct 2005

Subjects
- Life Sciences

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Response of rhlf-transgenic dairy cows to expermentally induced escherichia coli mastitis

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Mastitis in dairy production

Current knowledge and future solutions

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