New antimicrobial agents in mastitis therapy

Stefan Soback; Arthur Saran

New antimicrobial agents in mastitis therapy

in Mastitis in dairy production

Autor:innen:

Stefan Soback

Stefan Soback Departments of Food Safety and Udder Health, Kimron Veterinary Institute, Beit Dagan, Israel

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Arthur Saran

Arthur Saran Departments of Food Safety and Udder Health, Kimron Veterinary Institute, Beit Dagan, Israel

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Art:: Kapitel

Seiten:: 53–57

DOI:: https://doi.org/10.3920/9789086865505_005

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Mastitis is a disease caused by Gram-positive and -negative bacteria. For this reason antibiotics have always been essential in treatment of mastitis and almost all have been used. Antibiotics are used in mastitis therapy systemically and/or locally, consisting of intramammary antibiotic administration. The purpose of this presentation is to review new antimicrobial agents introduced to mastitis therapy during the years 1995-2005. Six compounds were considered belonging to the β-lactam, macrolide, lincosamide and fluoroquinolone groups. The β-lactams were amoxicillin combined with clavulanic acid and two advanced cephalosporins; ceftiofur and cefquinome, the macrolide tilmicosin and lincosamide pirlimycin, and the fluoroquinolone marbofloxacin. The β-lactams and marbofloxacin are broad-spectrum antibiotics and suitable for treatment of Gram-positive and -negative pathogens. The macrolide and lincosamide spectrum incorporates Gram-positive bacteria only. The advanced cephalosporins are generally more suitable for treatment of Gram-negative pathogens, but both ceftiofur and cefquinome have excellent activity, low minimum inhibitory concentration (MIC), against Gram-positive pathogens as well. These cephalosporins are also resistant to β-lactamase activity. The two macrolides also have low MIC values against relevant Gram-positive mastitis pathogens. The therapy regimens of some of these new compounds include intramammary only or combined intramammary and systemic treatment. Most studies indicate that combination therapy appears advantageous. It appears justified to conclude that efficacy of the therapy appears more influenced by pharmacokinetics than the MIC.

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Mastitis in dairy production

Current knowledge and future solutions

ISBN:: 9789086865505

Verleger:: Wageningen Academic

Print-Publikationsdatum:: 24 Oct 2005

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New antimicrobial agents in mastitis therapy

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Mastitis in dairy production

Current knowledge and future solutions

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