OrbesealÂ® and OrbeninÂ® EDC in combination for the treatment of intra-mammary infections at drying off and prevention of new infections during the dry period and early lactation in dairy cows

Andrew Bradley; Hamish Newton; Hafid Benchaoui; Nicola Tilt; Vic Cracknell; Tim Rowan

OrbesealÂ® and OrbeninÂ® EDC in combination for the treatment of intra-mammary infections at drying off and prevention of new infections during the dry period and early lactation in dairy cows

In: Mastitis in dairy production

Authors:

Andrew Bradley

Andrew Bradley ¹Veterinary Clinical Science, University of Bristol, Langford, Bristol, UK

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Hamish Newton

Hamish Newton ¹Veterinary Clinical Science, University of Bristol, Langford, Bristol, UK

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Hafid Benchaoui

Hafid Benchaoui ²Veterinary Medicine R & D, Pfizer Ltd, Sandwich, Kent, UK

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Nicola Tilt

Nicola Tilt ²Veterinary Medicine R & D, Pfizer Ltd, Sandwich, Kent, UK

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Vic Cracknell

Vic Cracknell ²Veterinary Medicine R & D, Pfizer Ltd, Sandwich, Kent, UK

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Tim Rowan

Tim Rowan ²Veterinary Medicine R & D, Pfizer Ltd, Sandwich, Kent, UK

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Type:: Chapter

Pages:: 339â344

DOI:: https://doi.org/10.3920/9789086865505_049

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Three hundred and thirteen (313) dairy cows from 10 commercial farms in the UK and with somatic cell counts (SCCs) above 200,000 cells/mL were enrolled in a GCP study. For each cow, treatments were randomised such that two quarters (one fore and one hind) were infused sequentially with a combination of OrbeSealÂ® and OrbeninÂ® EDC (626 quarters, T01) and two quarters with OrbeninÂ® EDC alone (626 quarters, T02). Treatments were administered as part of the standard veterinary preventative procedures on the day of drying off (day 0) for each cow. Bacteriological samples were collected on days -2, -1 and 0, and twice after calving (C), on day C+4 and between C+8 and C+11. Quarter SCCs (QSCCs) were measured on day 0 and between C+8 and C+11 days. Cows were monitored for clinical mastitis until day C+60. Clinical mastitis developed pre-calving in one quarter in T02, and post-calving in 16 quarters in T01 and 37 quarters in T02 (P<0.05). Analysis showed that, for quarters infected pre-treatment, there was no significant difference (P>0.05) between treatments in the elimination of existing infections or the prevention of new sub-clinical infections. The mean QSCCs for T01 and T02 were lower post-calving than at drying off. The combination of OrbeSealÂ® with OrbeninÂ® EDC was as effective as OrbeninÂ® EDC alone in the treatment of existing infections and performed significantly better in the prevention of clinical mastitis during the dry period and early lactation.

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Mastitis in dairy production

Current knowledge and future solutions

E-Book ISBN:: 9789086865505

Publisher:: Wageningen Academic

Print Publication Date:: 24 Oct 2005

Subjects
- Life Sciences

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OrbesealÂ® and OrbeninÂ® EDC in combination for the treatment of intra-mammary infections at drying off and prevention of new infections during the dry period and early lactation in dairy cows

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Mastitis in dairy production

Current knowledge and future solutions

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