Efficacy of a J-5 Escherichia coli bacterin in clinical coliform mastitis of dairy cattle

Hubert A. Deluyker; Karen Van Uffel; Gregory D. Elfring; Sophie N. Van Oye; Christopher Dutton; Ian Nanhjiani

Efficacy of a J-5 Escherichia coli bacterin in clinical coliform mastitis of dairy cattle

In: Mastitis in dairy production

Authors:

Hubert A. Deluyker

Hubert A. Deluyker ¹Pfizer Animal Health, Puurs, Belgium

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Karen Van Uffel

Karen Van Uffel ¹Pfizer Animal Health, Puurs, Belgium

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Gregory D. Elfring

Gregory D. Elfring ²Pfizer Animal Health, Kalamazoo, Michigan, USA

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Sophie N. Van Oye

Sophie N. Van Oye ¹Pfizer Animal Health, Puurs, Belgium

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Christopher Dutton

Christopher Dutton ³Pfizer Animal Health, Sandwich, United Kingdom

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, and

Ian Nanhjiani

Ian Nanhjiani ³Pfizer Animal Health, Sandwich, United Kingdom

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Type:: Chapter

Pages:: 285–289

DOI:: https://doi.org/10.3920/9789086865505_040

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The study objective was to determine the efficacy of Enviracor™ (Pfizer), a J-5 Escherichia coli bacterin, as an aid in preventing of clinical coliform mastitis under field conditions. Cows and heifers with seven month pregnancies in thirteen herds were randomly assigned to Enviracor™ or placebo (saline) treatment groups. Enviracor™ animals received three doses subcutaneously with the first dose targeted at 56 days pre-calving, the second dose 28±7 days later, and the third within 16 days after calving for a study period of 150 days of lactation. Of 1314 animals enrolled, 1118 animals (556 in placebo and 562 in Enviracor™ groups, respectively) were qualified for final analysis. The frequency of visual injection site swelling in vaccinates peaked at 48 hours post injection (60-65%) and was reduced by 72 hours. The incidence of toxic coliform mastitis was significantly higher for the placebo group than the Enviracor™ group (p=0.04) with a relative risk of 1.89. The likelihood of occurrence of one or more risk factors for mortality due to coliform mastitis was significantly lower for Enviracor™ treated cows compared to placebo (p<0.05) with an odds ratio of 3. This study shows that cows vaccinated with Enviracor™ were better able to react to severe coliform infections. As a result, they experienced a lower incidence of toxic mastitis and were at a lower risk of mortality following an incident of coliform mastitis.

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Mastitis in dairy production

Current knowledge and future solutions

E-Book ISBN:: 9789086865505

Publisher:: Wageningen Academic

Print Publication Date:: 24 Oct 2005

Subjects
- Life Sciences

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Efficacy of a J-5 Escherichia coli bacterin in clinical coliform mastitis of dairy cattle

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Mastitis in dairy production

Current knowledge and future solutions

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