Influence of resident milk neutrophils chemiluminescence and viability on the severity of bovine coliform mastitis

J. Mehrzad; L. Duchateau; C. Burvenich

Influence of resident milk neutrophils chemiluminescence and viability on the severity of bovine coliform mastitis

In: Mastitis in dairy production

Authors:

J. Mehrzad

J. Mehrzad ¹Dept. Physiology, Biochemistry and Biometrics, Ghent University, Merelbeke, Belgium
²Current address: McGill University, Dept. Animal Science

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L. Duchateau

L. Duchateau ¹Dept. Physiology, Biochemistry and Biometrics, Ghent University, Merelbeke, Belgium

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, and

C. Burvenich

C. Burvenich ¹Dept. Physiology, Biochemistry and Biometrics, Ghent University, Merelbeke, Belgium

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Type:: Chapter

Pages:: 178–184

DOI:: https://doi.org/10.3920/9789086865505_023

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Few early lactation-related infections in dairy cows are as important as mastitis. This complex inflammatory disease has been the past, current and future focus of many bovine immunologists. Although the impact of blood neutrophils on the pathogenesis of mastitis is clear, the influence of milk neutrophils on the outcome of mastitis is unclear. It has been shown that increased quantity of neutrophils in milk protects udder from invading pathogens. However, little attention has been paid on the qualitative role of milk neutrophils in mastitis severity. We hypothesised that when E. coli invade the udder, the pre-existing milk neutrophils would be critical for mastitis severity. In our study the cows were classified as moderate and severe responders according to milk production loss in the non-infected quarters at post-infection hour (PIH) 48. We observed that higher pre-infection milk neutrophils viability correlated with bacterial clearance, which was accompanied by faster recovery. There was a good correlation between milk neutrophils chemiluminescence and their viability. There was also an inverse relationship between pre-infection milk neutrophils chemiluminescence and colony-forming units at PIH 6. The probability of severe response increased with decreasing pre-infection milk neutrophils chemiluminescence and viability. High pre-infection milk neutrophils chemiluminescence and viability and the immediate increase of milk neutrophils chemiluminescence and viability after infection limited bacterial growth, thereby facilitating recovery of E. coli mastitis in moderate responders. Our study strongly supports the idea that pre-existing milk neutrophils acts as a cellular antibiotic before and during infection, and low milk neutrophils chemiluminescence and viability can be a risk factor for bovine coliform mastitis.

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Mastitis in dairy production

Current knowledge and future solutions

E-Book ISBN:: 9789086865505

Publisher:: Wageningen Academic

Print Publication Date:: 24 Oct 2005

Subjects
- Life Sciences

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Influence of resident milk neutrophils chemiluminescence and viability on the severity of bovine coliform mastitis

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Mastitis in dairy production

Current knowledge and future solutions

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