Effect of carprofen following experimentally induced E. coli mastitis in primiparous cows

F. Vangroenweghe; P. Boutet; P. Lekeux; R. Bossuyt; P. Rainard; M.J. Paape; L. Duchateau; C. Burvenich

Effect of carprofen following experimentally induced E. coli mastitis in primiparous cows

In: Mastitis in dairy production

Authors:

F. Vangroenweghe

F. Vangroenweghe ¹MMRC, Department of Physiology-Biochemistry-Biometrics, Ghent University, Merelbeke, Belgium

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P. Boutet

P. Boutet ²Département de Physiologie, Université de Liège, Liège, Belgium

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P. Lekeux

P. Lekeux ²Département de Physiologie, Université de Liège, Liège, Belgium

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R. Bossuyt

R. Bossuyt ³MelkControleCentrum, Lier, Belgium

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P. Rainard

P. Rainard ⁴Groupe Mammite, Pathologie Infectieuse et Immunologie, INRA, Nouzilly-Tours, France

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M.J. Paape

M.J. Paape ⁵Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, USA

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L. Duchateau

L. Duchateau ¹MMRC, Department of Physiology-Biochemistry-Biometrics, Ghent University, Merelbeke, Belgium

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, and

C. Burvenich

C. Burvenich ¹MMRC, Department of Physiology-Biochemistry-Biometrics, Ghent University, Merelbeke, Belgium

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Type:: Chapter

Pages:: 290–296

DOI:: https://doi.org/10.3920/9789086865505_041

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Acute Escherichia coli mastitis is one of the major sources of economic loss in the dairy industry, due to reduced milk production, treatment costs, discarded milk and occasional fatal disease. Non-steroidal anti-inflammatory drugs (NSAID’s) are frequently used as adjunctive therapy to antibiotics. The objective of the current study was to evaluate the effect of carprofen treatment following infusion of E. coli into the mammary glands of primiparous cows during the periparturient period. Carprofen is a powerful inhibitor of inducible enzymes of the cyclo-oxygenase pathway. The study was conducted to GCP standard under veterinary supervision and complied with applicable animal welfare and regulatory requirements. Severity of mastitis was scored based on the average milk production in the uninfected quarters on d+2 post-inoculation. All heifers reacted as moderate responders. Carprofen was administered at 9 h post-challenge, when clinical signs of mastitis appeared. In previous work, efficacy of NSAID’s was mainly evaluated using clinical symptoms. In the present study, the effect of carprofen on innate immune response was also assessed by quantification of inflammatory mediators. Primiparous cows were intramammarily inoculated with 1 x 10⁴ CFU E. coli P4:O32 in two left quarters. Analysis of blood and milk parameters, including IL-8, C5a, LBP, sCD14, PGE₂ and TXB₂, was performed from d0 to d+6 relative to intramammary inoculation. Rectal temperature in carprofen-treated animals was lower than that of control animals 3 and 6 h post-treatment (P < 0.05). Treatment also restored the decreased reticulorumen motility that occurs during E. coli mastitis to pre-infection levels faster than in control animals. Eicosanoid (PGE₂ and TXB₂) production in milk tended to be inhibited by carprofen. No significant differences in the kinetic patterns of SCC, IL-8, C5a, LBP and sCD14 were observed. In conclusion, in this study carprofen improved general clinical condition by effective antipyrexia and restoration of reticulorumen motility.

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Mastitis in dairy production

Current knowledge and future solutions

E-Book ISBN:: 9789086865505

Publisher:: Wageningen Academic

Print Publication Date:: 24 Oct 2005

Subjects
- Life Sciences

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Effect of carprofen following experimentally induced E. coli mastitis in primiparous cows

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Mastitis in dairy production

Current knowledge and future solutions

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