Lactobacilli and its metabolites as potential probiotics against Gardnerella vaginalis

C. Felgueiras; T.B. Cereija; A. Machado; N. Cerca; L.R. Rodrigues

Lactobacilli and its metabolites as potential probiotics against Gardnerella vaginalis

In: Industrial, medical and environmental applications of microorganisms

Authors:

C. Felgueiras

C. Felgueiras CEB-IBB, Campus de Gualtar, Universidade do Minho, Braga, Portugal; nunocerca@ceb.uminho.pt

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T.B. Cereija

T.B. Cereija CEB-IBB, Campus de Gualtar, Universidade do Minho, Braga, Portugal; nunocerca@ceb.uminho.pt

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A. Machado

A. Machado CEB-IBB, Campus de Gualtar, Universidade do Minho, Braga, Portugal; nunocerca@ceb.uminho.pt

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N. Cerca

N. Cerca CEB-IBB, Campus de Gualtar, Universidade do Minho, Braga, Portugal; nunocerca@ceb.uminho.pt

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L.R. Rodrigues

L.R. Rodrigues CEB-IBB, Campus de Gualtar, Universidade do Minho, Braga, Portugal; nunocerca@ceb.uminho.pt

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Type:: Chapter

Pages:: 541–546

DOI:: https://doi.org/10.3920/9789086867950_096

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Bacterial vaginosis (BV) is one of the most common gynecological disorder affecting women in reproductive age. Current BV treatment is strictly based in antibiotic therapy but has result in an increased resistance of BV anaerobes, especially Gardnerella vaginalis. One alternative therapy for BV is the recolonisation of vagina with lactobacilli species. Our goal was to evaluate the probiotic potential of intra and extracellular metabolites from a broad range of lactobacilli strains against several G. vaginalis strains. To accomplish our goal, we isolated 60 vaginal lactobacilli strains from healthy women and performed a screening by an agar spot test against 9 G. vaginalis strains. We also included 30 colection strains. For the best candidates we determined the minimum inhibitory concentration and identified the lactobacilli metabolites responsible for G. vaginalis growth inhibition. Overall, from the 90 lactobacilli strains tested, only 4 culture collection and 3 clinical isolate lactobacilli strains exhibited a broad probiotic activity against all the G. vaginalis strains tested. Therefore, our data suggests the existence of non-vaginal lactobacilli strains possessing probiotic activity against numerous G. vaginalis strains, which may contribute for a new and more effective BV treatment than the currently used therapies.

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Industrial, medical and environmental applications of microorganisms

Current status and trends

E-Book ISBN:: 9789086867950

Publisher:: Wageningen Academic

Print Publication Date:: 01 Nov 2014

Subjects
- Life Sciences

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Lactobacilli and its metabolites as potential probiotics against Gardnerella vaginalis

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Industrial, medical and environmental applications of microorganisms

Current status and trends

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