In vitro and in vivo effects of fumonisin B1 on the intestine: A review

S. Bouhet; I.P. Oswald

In vitro and in vivo effects of fumonisin B₁ on the intestine: A review

In: Mycotoxins and phycotoxins

Authors:

S. Bouhet

S. Bouhet Laboratoire de Pharmacologie-Toxicologie, INRA, 180 Chemin de Tournefeuille, 31931 Toulouse Cedex 9, France; ioswald@toulouse.inra.fr

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I.P. Oswald

I.P. Oswald Laboratoire de Pharmacologie-Toxicologie, INRA, 180 Chemin de Tournefeuille, 31931 Toulouse Cedex 9, France; ioswald@toulouse.inra.fr

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Type:: Chapter

Pages:: 145–155

DOI:: https://doi.org/10.3920/9789086865857_015

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Fumonisins are a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly F. moniliforme), a common fungal contaminant of maize. Contamination with fumonisin B1 (FB₁) is of concern as this mycotoxin causes various animal diseases. The gastrointestinal tract represents the first barrier against ingested food contaminants. Following ingestion of fumonisincontaminated food or feed, intestinal epithelial cells could be exposed to a high concentration of toxin. In this review, we summarise data on the impact of FB₁ on the intestine. Although FB₁ is poorly absorbed and metabolised in the intestine, it induces intestinal disturbances (abdominal pain or diarrhoea) and causes extraintestinal organ pathologies (pulmonary edema, leukoencephalomalacia or neural tube defects). The main toxicological effect of FB₁ reported in vivo and in vitro is the accumulation of sphingoid bases as well as the depletion of complex sphingolipids. This disturbance of the sphingolipid biosynthesis pathway could explain the other observed toxicological effects such as alteration in intestinal epithelial cell viability and proliferation, modification of cytokine production, and modulation of intestinal physical barrier function.

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Mycotoxins and phycotoxins

Advances in determination, toxicology and exposure management

E-Book ISBN:: 9789086865857

Publisher:: Wageningen Academic

Print Publication Date:: 30 Oct 2006

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- Life Sciences

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In vitro and in vivo effects of fumonisin B1 on the intestine: A review

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Mycotoxins and phycotoxins

Advances in determination, toxicology and exposure management

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In vitro and in vivo effects of fumonisin B₁ on the intestine: A review