Host response reactions of the lactating ovine udder during experimental challenge with Staphylococcus epidermidis

Petra Winter; Klemens Fuchs; Franz Schilcher; Ian G. Colditz

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Host response reactions of the lactating ovine udder during experimental challenge with Staphylococcus epidermidis

In: Mastitis in dairy production

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Petra Winter

Petra Winter

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Klemens Fuchs

Klemens Fuchs

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Franz Schilcher

Franz Schilcher

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Ian G. Colditz

Ian G. Colditz

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Type:: Chapter

Pages:: 517–522

DOI:: https://doi.org/10.3920/9789086865505_078

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The responses of five lactating Merino wool sheep (M) and 5 lactating East Friesian milk ewes (EF) to experimental mammary infection with Staphylococcus epidermidis were examined. Infection caused an influx of neutrophils into milk, the numbers of which started to rise 4 h after infection (p. i.) and peaked 8 to 24 h after infection. The initial response was accompanied by mild fever and mild leucopaenia in blood. No other signs of systemic infection were observed. At all times milk appeared normal. Numbers of staphylococci decreased logarithmically until 24 h, were absent from three (M) and four ewes (EF) two and three days p. i., but re-emerged intermittently in four of five ewes at subsequent samplings in both studies. Cytokines in milk were measured by ELISA. IL-8 was elevated in infected glands at 2 h and peaked at 8 h to 24 h. In the ewes intermittently shedding bacteria, IL-8 remained elevated until the final sampling at 10 weeks. IL-1β was transiently elevated at 1 and 2 d. One EF sheep showed an intense peak of IL-1β. Milk samples from this EF ewe were bacteriologically negative, and the concentrations of IL-1β, as well as IL- 8, were low from one week p. i. until the final sampling. Histological examination revealed leucocytic infiltrates in the four EF glands remaining infected, and a high level of CD5+ lymphocytes in three ewes. The results of both studies showed that the intense early neutrophil infiltrate eliminated most but not all bacteria and a state of subclinical infection ensued. The course of infection is determined by the relationship between the initial neutrophil influx and the proinflammatory cytokines.

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Mastitis in dairy production

Current knowledge and future solutions

E-Book ISBN:: 9789086865505

Publisher:: Wageningen Academic

Print Publication Date:: 24 Oct 2005

Subjects
- Life Sciences

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Host response reactions of the lactating ovine udder during experimental challenge with Staphylococcus epidermidis

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Mastitis in dairy production

Current knowledge and future solutions

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