Whey protein is beneficial for rotavirus induced diarrhoea in preclinical studies

M. Rigo-Adrover; A. Franch; M. Castell; C. Castellote; F.J. Pérez-Cano

Whey protein is beneficial for rotavirus induced diarrhoea in preclinical studies

于Handbook of dietary and nutritional aspects of bottle feeding

著者：

M. Rigo-Adrover

M. Rigo-Adrover ¹Department of Physiology, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n,08028 Barcelona, Spain

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A. Franch

A. Franch ¹Department of Physiology, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n,08028 Barcelona, Spain
²Institut de Recerca en Nutrició i Seguretat Alimentària (INSA),University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain franciscoperez@ub.edu

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M. Castell

M. Castell ¹Department of Physiology, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n,08028 Barcelona, Spain
²Institut de Recerca en Nutrició i Seguretat Alimentària (INSA),University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain franciscoperez@ub.edu

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C. Castellote

C. Castellote ¹Department of Physiology, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n,08028 Barcelona, Spain
²Institut de Recerca en Nutrició i Seguretat Alimentària (INSA),University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain franciscoperez@ub.edu

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F.J. Pérez-Cano

F.J. Pérez-Cano ¹Department of Physiology, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n,08028 Barcelona, Spain
²Institut de Recerca en Nutrició i Seguretat Alimentària (INSA),University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain franciscoperez@ub.edu

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类型:: 章节

Page Range:: 491–506

DOI:: https://doi.org/10.3920/9789086867776_032

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Group A rotavirus (RV) is the leading cause of diarrhoeal disease among young children worldwide. The symptoms range from asymptomatic shedding to severe dehydration and even death. After RV, infection immunity is not complete and reinfections usually occur. Although two oral vaccines are available, the diarrhoea process can be modulated by dietary interventions with bioactive components. Breast milk contains whey proteins (WP) whose capacity to inhibit RV infection has been demonstrated both in vitro and in vivo. In this context, several animal models, mainly using mice and rats, have been used to explore RV infection and its pathology, clinical and immune response, and to test vaccine efficacy or nutritional modulation of the process. These models are mainly based on homologous or heterologous RV inoculation in suckling rodents, which develop mild-severe diarrhoea, evaluated by clinical and immune variables. On the one hand, hyperimmune colostrums reduce the disease incidence, severity, duration and viral shedding, and modify the immunity response in calves and germfree pigs. In the neonatal mouse model, they are able to prevent diarrhoea and modulate the viral shedding. On the other hand, whey protein concentrates and in particular WP are also able to modulate the diarrhoea process (i.e. incidence and severity) and affect the viral clearance and some aspects of immune response in the neonatal mouse and rat models. In conclusion, as it is well documented that WP are good nutritive supplements due to their capabilities to modulate immunity and given data of rotavirus protection in preclinical studies, the importance of these components in infant formulas should be considered in order to guarantee the same protective function provided by breast milk in breastfed babies.

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Handbook of dietary and nutritional aspects of bottle feeding

丛编： Human Health Handbooks, 卷： 8

ISBN:: 9789086867776

出版社:: Wageningen Academic

印刷出版日期:: 28 Nov 2014

Subjects
- Life Sciences
  - General
  - Food & Health

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Whey protein is beneficial for rotavirus induced diarrhoea in preclinical studies

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