An investigation of factors affecting cure when treating clinical mastitis in dairy cattle with cephalosporin containing intramammary preparations

A.J. Bradley; M.J. Green

An investigation of factors affecting cure when treating clinical mastitis in dairy cattle with cephalosporin containing intramammary preparations

In: Mastitis control

Authors:

A.J. Bradley

A.J. Bradley ¹University of Bristol, Division of Farm Animal Science, School of Veterinary Science, Langford House, Langford, BS40 5DU Bristol, United Kingdom
²Quality Milk Management Services Ltd, Unit 1, Lodge Hill Industrial Park, Station Road, Westbury-sub-Mendip, Nr Wells, BA5 1EY Somerset, United Kingdom

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M.J. Green

M.J. Green ³University of Nottingham, School of Veterinary Medicine and Science, Sutton Bonington Campus, Sutton Bonington, LE12 5RD Leicestershire, United Kingdom Corresponding author: a.j.bradley@bris.ac.uk

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Type:: Chapter

Pages:: 283–291

DOI:: https://doi.org/10.3920/9789086866496_051

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Data were collated for an independent scientific analysis from a number of international, multicentre studies that had compared the efficacy of three different, cephalosporin containing, intramammary preparations in the treatment of clinical mastitis in dairy cattle (cefalexin in combination with kanamycin (group 1); cefquinome (group 2); cefoperazone (group 3)). Quarters were assessed using standard bacteriological techniques before treatment and at 16 and 25 days post treatment. Additional data were also available on individual cows and study farms including parity, breed and cow somatic cell count histories, herd bulk milk somatic cell counts (BMSCC) and farm management regimes. Sufficient data for analysis was available from a total of 491 cases on 192 farms in 3 countries (England, France and Germany) with up to 16 cases being recruited from any one farm. Clinical cases were of diverse aetiology representing both contagious and environmental pathogens. Univariable analysis demonstrated that quarters in treatment groups 1 (88/148) and 2 (55/89) were not significantly different from each other, but were both significantly more likely to be pathogen free post treatment than quarters in group 3 (24/87), (P=0.021). Multivariable analysis using conventional random effects models indicated that country, pre-treatment rectal temperature (above normal temperature associated with increased chance of being pathogen free post treatment), individual cow somatic cell count (increased SCC associated with decreased chance of being pathogen free post treatment) and pathogen (Staphylococcus aureus isolation associated with decreased chance of being pathogen free post treatment) were useful predictors of pathogen free status; parity, yield, BMSCC and other farm management factors were not. The results suggest that the factors important in predicting the outcome of treatment of clinical mastitis cases may be dissimilar to those reported to affect the likelihood of cure when treating subclinical intramammary infections.

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Mastitis control

From science to practice

E-Book ISBN:: 9789086866496

Publisher:: Wageningen Academic

Print Publication Date:: 30 Oct 2008

Subjects
- Life Sciences

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An investigation of factors affecting cure when treating clinical mastitis in dairy cattle with cephalosporin containing intramammary preparations

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Mastitis control

From science to practice

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