Epidemiologic association of Staphylococcus aureus virulencemarkers with intramammary infection chronicity

B.V. LeThanh; C.J. Lebeau; S. Messier; F. Malouin; D. Scholl

Epidemiologic association of Staphylococcus aureus virulencemarkers with intramammary infection chronicity

In: Mastitis control

Authors:

B.V. LeThanh

B.V. LeThanh ¹University of Montreal, Faculty of Veterinary Medicine, 3200 rue Sicotte, Saint-Hyacinthe (QC) J2S 2M2, Canada
³Canadian Bovine Mastitis Research Network Corresponding author: daniel.scholl@umontreal.ca

Search for other papers by B.V. LeThanh in
Current site
Google Scholar
PubMed

C.J. Lebeau

C.J. Lebeau ²University of Sherbrooke, Department of Biology, 2500 boul. Université, Sherbrooke (QC) J1K 2R1, Canada
³Canadian Bovine Mastitis Research Network Corresponding author: daniel.scholl@umontreal.ca

Search for other papers by C.J. Lebeau in
Current site
Google Scholar
PubMed

S. Messier

S. Messier ¹University of Montreal, Faculty of Veterinary Medicine, 3200 rue Sicotte, Saint-Hyacinthe (QC) J2S 2M2, Canada
³Canadian Bovine Mastitis Research Network Corresponding author: daniel.scholl@umontreal.ca

Search for other papers by S. Messier in
Current site
Google Scholar
PubMed

F. Malouin

F. Malouin ²University of Sherbrooke, Department of Biology, 2500 boul. Université, Sherbrooke (QC) J1K 2R1, Canada
³Canadian Bovine Mastitis Research Network Corresponding author: daniel.scholl@umontreal.ca

Search for other papers by F. Malouin in
Current site
Google Scholar
PubMed

, and

D. Scholl

D. Scholl ¹University of Montreal, Faculty of Veterinary Medicine, 3200 rue Sicotte, Saint-Hyacinthe (QC) J2S 2M2, Canada
³Canadian Bovine Mastitis Research Network Corresponding author: daniel.scholl@umontreal.ca

Search for other papers by D. Scholl in
Current site
Google Scholar
PubMed

Type:: Chapter

Pages:: 165–174

DOI:: https://doi.org/10.3920/9789086866496_036

Purchase instant access (PDF download and unlimited online access):

€42.00€35.00 excl. VAT

Add to Cart

Redeem Access Token

Despite effective techniques for controlling Staphylococcus aureus intramammary infection (IMI), it is still one of the most predominant causes of IMI in many dairy populations. The pathogen has an advantage due to many strains’ ability to infect chronically and persistently without severe clinical signs. We hypothesised that the genetic profile of IMI-causing strains of S. aureus is associated with the likelihood of causing a chronic IMI versus an acute clinical IMI. To test this hypothesis, a prospective case-control study of 91 Canadian commercial dairy farms was initiated. The profiles of specific target genes are determined by multiplex PCR reactions on S. aureus isolated from chronic IMI (detected at the end of lactation [cases]) and from clinical IMI (controls) in the cohort. The preliminary analyses presented in this paper are of association of cases and controls with phenotypic expressions of haemolysis and biofilm formation, which are hypothesised to be related to expression of genes that are important in promoting subclinical chronic IMI. Isolates from 164 subclinical cases at the end of lactation and 82 clinical controls during lactation were studied. Expression of beta-haemolysis or weak beta-haemolysis was associated with subclinical infection (Odds ratio 2.1, 95% confidence interval 1.1 to 4.0). Isolates from subclinical IMI formed more biofilm than isolates from clinical IMI (P<0.01). Further examination of the S. aureus virulence genes and genotypes that are involved in controlling biofilm formation and beta-haemolysis is warranted in order to gain a more thorough understanding of how S. aureus establishes subclinical, and presumably chronic, infections. Knowing genetic markers for strains more likely to cause chronic IMI could enable targeted diagnostics, treatments or vaccination.

Citation Info

Save
Cite
Email this content

Share link with colleague or librarian

You can email a link to this page to a colleague or librarian:
Email this content
or copy the link directly:

https://brill.edhh.ma/abstract/book/9789086866496/BP000036.xml
The link was not copied. Your current browser may not support copying via this button.

Link copied successfully

Collapse
Expand

Mastitis control

From science to practice

E-Book ISBN:: 9789086866496

Publisher:: Wageningen Academic

Print Publication Date:: 30 Oct 2008

Subjects
- Life Sciences

Metrics

	All Time	Past 365 days	Past 30 Days
Abstract Views	76	33	10
Full Text Views	6	1	0
PDF Views & Downloads	0	0	0

African Studies	Education	Media Studies
American Studies	History	Middle East and Islamic Studies
Ancient Near East and Egypt	Human Rights and Humanitarian Law	Musicology
Art History	International Law	Philosophy
Asian Studies	International Relations	Religious Studies
Biblical Studies	Jewish Studies	Slavic and Eurasian Studies
Biology	Languages and Linguistics	Social Sciences
Book History and Cartography	Life Sciences	Theology and World Christianity
Classical Studies	Literature and Cultural Studies

Subjects

Authors

Open Access

Product Information

Company

Contact

Epidemiologic association of Staphylococcus aureus virulencemarkers with intramammary infection chronicity

Citation Info

Share link with colleague or librarian

Mastitis control

From science to practice

Table of Contents

Metrics

Metrics