Parameters for natural resistance in bovine milk

T.C.W. Ploegaert; E.J. Tijhaar; H.K. Parmentier; J.J. van der Poel; J.A.M. van Arendonk; H.F.J. Savelkoul

Parameters for natural resistance in bovine milk

In: Mastitis control

Authors:

T.C.W. Ploegaert

T.C.W. Ploegaert ¹Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, the Netherlands

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E.J. Tijhaar

E.J. Tijhaar ¹Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, the Netherlands

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H.K. Parmentier

H.K. Parmentier ²Section of Immunology, Adaptation Physiology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, the Netherlands

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J.J. van der Poel

J.J. van der Poel ³Animal Breeding and Genetics Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, the Netherlands Corresponding author: Tosca.ploegaert@wur.nl

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J.A.M. van Arendonk

J.A.M. van Arendonk ³Animal Breeding and Genetics Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, the Netherlands Corresponding author: Tosca.ploegaert@wur.nl

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H.F.J. Savelkoul

H.F.J. Savelkoul ¹Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, the Netherlands

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Type:: Chapter

Pages:: 103–109

DOI:: https://doi.org/10.3920/9789086866496_019

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Natural disease resistance of the cow is one of the factors that can play a role in preventing and combating mastitis. It is well documented how immune parameters change following an experimental mammary infection with different pathogens. However, knowledge of the role of natural resistance to infection and parameters to best measure natural resistance in an uninfected animal, is scarce. The hypothesis of this project is that such parameters of natural resistance in milk do correlate with the cow’s capacity to resist mastitis. Identification of such parameters can enable the development of tests to monitor the level of natural resistance to mastitis on the dairy farm in a non-invasive way. Monitoring of natural resistance supports the farmer in managing the herd. For this project milk and blood samples were taken from cows without clinical signs of diseases to study: (1) the repeatability of the selected parameters within cows; (2) variation of these parameters between cows; and (3) the relation between these parameters in milk and blood. The humoral parameters that were measured included cytokines, like TNFα (pro-inflammatory) and IFNγ (cell mediated immunity), and (naturally occurring) antibodies against different pathogen associated molecular patterns (PAMPs). The (natural) antibody titres and to a lesser extend the cytokine levels, showed repeatability within and variation between cows. These selected parameters are being measured in milk samples of nearly 2000 heifers of the Dutch Milk Genomics project with known mastitis history to study their relation with natural resistance to mastitis and heritability of measured parameters.

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Mastitis control

From science to practice

E-Book ISBN:: 9789086866496

Publisher:: Wageningen Academic

Print Publication Date:: 30 Oct 2008

Subjects
- Life Sciences

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Parameters for natural resistance in bovine milk

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Mastitis control

From science to practice

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