A dietary portfolio containing viscous fibre in the control of serum cholesterol

C.W.C. Kendall; A.R. Josse; T.H. Nguyen; H. Jiang; S. Abdulnour; J.M.W. Wong; D.J.A. Jenkins

A dietary portfolio containing viscous fibre in the control of serum cholesterol

in Dietary fibre components and functions

Autor:innen:

C.W.C. Kendall

C.W.C. Kendall ¹Clinical Nutrition & Risk Factor Modification Center; Faculty of Medicine, University of Toronto, 150 College Street, Toronto, M5S 3E2 Ontario, Canada; cyril.kendall@utoronto.ca
³Departments of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⁵College of Pharmacy and Nutrition, University of Saskatchowan, Saskatoon, Saskatchewan, Canada

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A.R. Josse

A.R. Josse ¹Clinical Nutrition & Risk Factor Modification Center; Faculty of Medicine, University of Toronto, 150 College Street, Toronto, M5S 3E2 Ontario, Canada; cyril.kendall@utoronto.ca
³Departments of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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T.H. Nguyen

T.H. Nguyen ¹Clinical Nutrition & Risk Factor Modification Center; Faculty of Medicine, University of Toronto, 150 College Street, Toronto, M5S 3E2 Ontario, Canada; cyril.kendall@utoronto.ca
³Departments of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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H. Jiang

H. Jiang ¹Clinical Nutrition & Risk Factor Modification Center; Faculty of Medicine, University of Toronto, 150 College Street, Toronto, M5S 3E2 Ontario, Canada; cyril.kendall@utoronto.ca
³Departments of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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S. Abdulnour

S. Abdulnour ¹Clinical Nutrition & Risk Factor Modification Center; Faculty of Medicine, University of Toronto, 150 College Street, Toronto, M5S 3E2 Ontario, Canada; cyril.kendall@utoronto.ca
³Departments of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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J.M.W. Wong

J.M.W. Wong ¹Clinical Nutrition & Risk Factor Modification Center; Faculty of Medicine, University of Toronto, 150 College Street, Toronto, M5S 3E2 Ontario, Canada; cyril.kendall@utoronto.ca
³Departments of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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, und

D.J.A. Jenkins

D.J.A. Jenkins ¹Clinical Nutrition & Risk Factor Modification Center; Faculty of Medicine, University of Toronto, 150 College Street, Toronto, M5S 3E2 Ontario, Canada; cyril.kendall@utoronto.ca
⁴Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Art:: Kapitel

Seiten:: 291–303

DOI:: https://doi.org/10.3920/978-90-8686-622-9_021

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The diet of early hominids was likely to have been plant based and would have contained high levels of fibre and other cholesterol-lowering components, including plant proteins, phytosterols and nuts, and as such, serum cholesterol concentrations were likely to have been low. We therefore wished to determine whether a modern day dietary portfolio (a combination dietary approach) containing viscous fibre and other cholesterol-lowering components could produce clinically significant serum cholesterol reductions. In a series of metabolically controlled studies, we assessed the cholesterol-lowering efficacy of viscous fibres (from oats, barley, psyllium, okra and eggplant) in combination with other cholesterol-lowering foods (almonds and soy protein) and food components (plant sterols) in the same diet (dietary portfolio) to maximise the effect of fibre. We have gone on to assess the long-term effectiveness of the dietary portfolio over a one-year period by studying a group of 66 hyperlipidemic individuals who had been instructed to follow a self-selected dietary portfolio. In the metabolic studies approximately 30% reductions in LDL-Cholesterol (LDL-C) and reductions in C-reactive protein were seen. The effects were similar to a first generation statin (Lovastatin). At one year, the combination diet approach resulted in mean reductions in LDL-C of 12.8%. Reductions were related to compliance with the diet. In approximately one third of the subjects who closely followed the diet, significant and clinically meaningful reductions in LDL-C of greater than 20% were achieved together with lower blood pressure and a reduced neutrophil:lymphocyte ratio, a new hematologic marker of coronary heart disease (CHD) risk. The dietary portfolio, including fibre, is an effective approach for maximising cholesterol reductions and decreasing the risk for CHD in those individuals who are prepared to make a significant change to their diet.

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Dietary fibre components and functions

ISBN:: 9789086866229

Verleger:: Wageningen Academic

Print-Publikationsdatum:: 24 Oct 2007

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A dietary portfolio containing viscous fibre in the control of serum cholesterol

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Dietary fibre components and functions

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