Wolbachia in Aedes mosquitoes: towards biological control of vector-borne diseases

Luciano A. Moreira

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Wolbachia in Aedes mosquitoes: towards biological control of vector-borne diseases

In: Ecology of parasite-vector interactions

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Luciano A. Moreira

Luciano A. Moreira
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Type:: Chapter

Pages:: 155–165

DOI:: https://doi.org/10.3920/9789086867448_010

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Dar Hadith al Hassania

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Dengue causes an enormous impact on global public health with 50 million cases every year. Vector control is predominantly focused on the application of insecticides against adult mosquitoes. However, current methods of vector control are often not sustainable for long periods because of the emergence of insecticide resistance. In this context, the discovery and application of alternative methods are extremely important. A new approach for biological control of diseases transmitted by mosquitoes has recently been proposed that uses an endosymbiotic bacterium (Wolbachia pipientis) in order to interfere with the transmission of pathogens. The advantage of using this bacterium is that infected females have a reproductive advantage due to a cytoplasmic incompatibility (CI), which leads to an increase in numbers of infected individuals in the wild. When Aedes aegypti mosquitoes (that naturally lack this bacterium) were transinfected with Wolbachia it was discovered that the presence of bacteria inhibits the replication of pathogens such as dengue and chikungunya viruses as well as filarial and avian malaria parasites. More recently Ae. aegypti mosquitoes harbouring a Drosophila-Wolbachia strain have been released in Australia and were able to quickly spread in the wild. In this chapter we review the possibility of applying this endosymbiotic bacteria as potential biological control of human diseases transmitted by mosquito vectors.

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Ecology of parasite-vector interactions

Series: Ecology and Control of Vector-borne Diseases, Volume: 3

E-Book ISBN:: 9789086867448

Publisher:: Wageningen Academic

Print Publication Date:: 15 Nov 2013

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- Life Sciences

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Wolbachia in Aedes mosquitoes: towards biological control of vector-borne diseases

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Ecology of parasite-vector interactions

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