Impact of transgenic immune deployment on mosquito fitness

Andrew D. Pike; Chris M. Cirimotich; George Dimopoulos

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Impact of transgenic immune deployment on mosquito fitness

In: Ecology of parasite-vector interactions

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Andrew D. Pike

Andrew D. Pike
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Chris M. Cirimotich

Chris M. Cirimotich
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George Dimopoulos

George Dimopoulos
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Type:: Chapter

Pages:: 17–33

DOI:: https://doi.org/10.3920/9789086867448_004

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Dar Hadith al Hassania

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Mosquitoes are the vectors of pathogens causing numerous human diseases, including dengue and malaria. Due to increases in drug resistance among pathogens or the lack of effective treatments for these diseases and increasing insecticide resistance among mosquito populations, new methods of control are urgently needed to limit the morbidity and mortality caused by vectorborne diseases. Mosquitoes possess an innate immune system capable of limiting infection with human pathogens, and the creation and deployment of transgenic mosquitoes with an enhanced immune system has been suggested as a novel means to reduce mosquito vector competence. However, activation of the immune system is often associated with a cost to the host, which could limit the ability of the transgenic insects to replace their wild-type conspecifics. Here, we discuss recent research into the effects of increased immune deployment and insect transgenesis on the fitness of the mosquitoes.

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Ecology of parasite-vector interactions

Series: Ecology and Control of Vector-borne Diseases, Volume: 3

E-Book ISBN:: 9789086867448

Publisher:: Wageningen Academic

Print Publication Date:: 15 Nov 2013

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- Life Sciences

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Impact of transgenic immune deployment on mosquito fitness

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Ecology of parasite-vector interactions

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