3. Vitamin D and cardiovascular disease

Y. Kumar; A. Bhatia

3. Vitamin D and cardiovascular disease

In: Handbook of nutrition in heart health

Authors:

Y. Kumar

Y. Kumar Department of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

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A. Bhatia

A. Bhatia Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

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Type:: Chapter

Pages:: 49–75

DOI:: https://doi.org/10.3920/978-90-8686-853-7_3

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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality and has a significant impact on health care systems. Changing lifestyle and increasing environmental pollution are giving fuel to its incidence. Besides these, there are certain emerging conditions which also have been proposed to increase the risk of CVD and vitamin D deficiency is one of them. In recent years, the scientists have put all their efforts in exploring the relation between vitamin D and CVD. Formation of atherosclerotic plaque and several other processes including endothelial dysfunction, cardiomyocyte proliferation, inflammation, immune activation, hormonal imbalance, dyslipidemia, platelet activation, thrombus formation, oxidative stress, altered matrix metabolism contribute to development of CVD. Vitamin D has been shown to play a role in the pathogenesis of CVD by affecting all these processes. This chapter is an attempt to summarize the available information related to vitamin D and its possible role in CVD. In the first half, this chapter gives an overview of vitamin D, its biological functions, routine requirements, and definition of vitamin D deficiency. In the second half, it covers various mechanisms proposed to be altered by vitamin D deficiency which are likely to be involved in the causation of CVD. At the end, the link between vitamin D and various CVD related conditions and cardiovascular events is discussed.

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Handbook of nutrition in heart health

Series: Human Health Handbooks, Volume: 14

E-Book ISBN:: 9789086868537

Publisher:: Wageningen Academic

Print Publication Date:: 20 Sep 2017

Subjects
- Life Sciences
  - General
  - Food & Health

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3. Vitamin D and cardiovascular disease

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Handbook of nutrition in heart health

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