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Randomised trial on neuroprotective effects of six-weeks TRX trainings on body flexibilities and neurotrophic factors in aged women

in Comparative Exercise Physiology
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R. Angizeh Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
Department of Exercise Physiology, Faculty of Sport Sciences and Health, Tehran University, Tehran, Iran

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https://orcid.org/0009-0000-0930-4076
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T.A. Nozari Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran

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https://orcid.org/0009-0006-7722-5955
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F. Rezvani Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran

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https://orcid.org/0009-0001-9145-3552
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F. Hatami Motor Behavior Department, Faculty of Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran

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https://orcid.org/0000-0003-3493-5966
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N. Tahmasebipour Department of Psychology and Educational Sciences, Faculty of Human Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran

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https://orcid.org/0000-0002-0924-2052
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G. Ashabi Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
Health Professions Education Research Center, Education Development Center, Tehran University of Medical Sciences, Tehran, Iran

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https://orcid.org/0000-0002-4853-092X
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M. Salehpour Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran

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https://orcid.org/0000-0002-6208-2502
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Abstract

Age-related physiological declines may lead to neurodegenerative diseases and cognitive disorders that can be modulated by resistance trainings. We investigated the effects of six weeks total body resistance exercises (TRX) on basic fibroblast growth factor (bFGF), glial cell line derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF), flexibility and cardiovascular endurance in elderly women. Twenty-eight healthy women (65.5 ± 4.5 years) were randomly assigned into TRX (n = 15) or control groups (n = 13). The training protocol consisted of six weeks of TRX (two weekly sessions). The participants in the control group were asked to avoid any activities beyond their daily activities. Before and after the study Fullerton Functional Fitness Assessment Tests, the Mini-Mental State Examination (MMSE) and blood tests were conducted to measure physical fitness and neurotrophic factors, respectively. Data analysis illustrated increases in bFGF ( P < 0.05), GDNF and BDNF ( P < 0.001) in TRX group compared to the control group. TRX group demonstrated improvements in cardiovascular endurance and flexibilities more than the control group ( P < 0.05). Our findings highlight the efficacy of TRX suspension trainings in improving physical fitness and neurotrophic factors through the activation of tropomyosin receptor kinase B (TrkB), fibronectin type III domain-containing protein 5 (FNDC5) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Therefore, the training protocol can prove benefits for this demographic group.

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