Effects of running and swimming on pain relief in male rats with type 2 diabetes-induced peripheral neuropathy
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Abstract
Type 2 diabetes (T2D) is the most prevalent type of diabetes and can lead to painful peripheral neuropathy (PN). Exercise can alleviate PN-related pain, but the comparative effects of running and swimming remain underexplored. Methods: Forty-eight male Wistar rats were randomly divided into: control (C), swimming (Sw), running (Run), diabetes (D), D-Sw, and D-Run. T2D was induced by high-fat-diet (60%) and streptozotocin (35 mg/kg). Rats underwent individualised swimming or running (8-weeks, 5 days/week, 60 min/day). Body weight gain (BWG), FBG, HOMA-IR, lipid profiles, and neuropathy tests: PWT (paw-withdrawal-threshold), LT (licking-time), FN (flinching-number), MSCP (cold-plate-mean-speed), EI (escape-index), CPE (cold-plate-entries) were measured. Data analysed using repeated measures ANOVA and equivalent non-parametric tests (
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Effects of running and swimming on pain relief in male rats with type 2 diabetes-induced peripheral neuropathy
In: Comparative Exercise PhysiologySearch for other papers by S. Fatolahi in
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Department of Physical Education & Sport Sciences, Yazd University, Yazd, Iran
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Abstract
Type 2 diabetes (T2D) is the most prevalent type of diabetes and can lead to painful peripheral neuropathy (PN). Exercise can alleviate PN-related pain, but the comparative effects of running and swimming remain underexplored. Methods: Forty-eight male Wistar rats were randomly divided into: control (C), swimming (Sw), running (Run), diabetes (D), D-Sw, and D-Run. T2D was induced by high-fat-diet (60%) and streptozotocin (35 mg/kg). Rats underwent individualised swimming or running (8-weeks, 5 days/week, 60 min/day). Body weight gain (BWG), FBG, HOMA-IR, lipid profiles, and neuropathy tests: PWT (paw-withdrawal-threshold), LT (licking-time), FN (flinching-number), MSCP (cold-plate-mean-speed), EI (escape-index), CPE (cold-plate-entries) were measured. Data analysed using repeated measures ANOVA and equivalent non-parametric tests (
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