Leisure-time regular exercise and prevention of the side effects of immune system activity in middle-aged healthy subjects
In: Comparative Exercise PhysiologySearch for other papers by S.R. Rahimi Moghaddam in
Current site
Google Scholar
Search for other papers by J. Mehrabani in
Current site
Google Scholar
Search for other papers by H. Berahman in
Current site
Google Scholar
Search for other papers by A. Elmieh in
Current site
Google Scholar
Search for other papers by M.R. Fadaei Chafy in
Current site
Google Scholar
Regular exercise is recommended to improve immune system function and antioxidant activity, while conversely, it may cause inflammation by increasing neutrophil-derived main enzyme, myeloperoxidase, which produces reactive oxygen species. The present study aimed to investigate changes in myeloperoxidase level, its influence on total oxidant status, and the capacity of the antioxidant defence system to counteract oxidative stress in middle-aged men participating in leisure-time regular exercise compared to untrained peer subjects. Twenty trained (age 53.58±2.94 years, body mass index (BMI) 25.47±1.6) and 17 untrained (age 54.17±2.83 years, BMI 27.83±1.12) healthy middle-aged men participated in this study [Rasht, Gilan, Iran]. Participants performed a modified Bruce treadmill test as a model of progressive exercise training. Blood samples were taken before, immediately after, and one hour after the end of the test. A mixed ANOVA and Bonferroni post hoc test was used for the analysis of variables. A significant difference was observed in myeloperoxidase levels between groups, while the trained group showed a significantly lower concentration than the untrained group (P<0.018). This result was also consistent with the lower total oxidant status in this group (P<0.001). Total antioxidant capacity changed significantly in both groups with higher concentration in the trained group (P<0.001). The leisure-time regular exercise can reduce myeloperoxidase concentration and total oxidant status in healthy middle-aged men while increasing the total antioxidant capacity, which may potentially protect them from the side effects of immune system activity induced by exercise training.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Akgun, E., Tuzuner, M.B., Sahin, B., Kilercik, M., Kulah, C., Cakiroglu, H.N., Serteser, M., Unsal, I. and Baykal, A.T., 2020. Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients. PLoS ONE 15: e0240012. https://doi.org/10.1371/journal.pone.0240012
-
Autenrieth, C.S., Emeny, R.T., Herder, C., Döring, A., Peters, A., Koenig, W. and Thorand, B., 2011. Myeloperoxidase, but not oxidized LDL, is associated with leisure-time physical activity: results from the MONICA/KORA Augsburg Studies 1984-1995. Atherosclerosis 219: 774-777. https://doi.org/10.1016/j.atherosclerosis.2011.07.125
-
Bouzid, M.A., Filaire, E., Matran, R., Robin, S. and Fabre, C., 2018. Lifelong voluntary exercise modulates age-related changes in oxidative stress. International Journal of Sports Medicine 39: 21-28. https://doi.org/10.1055/s-0043-119882
-
Carraro, E., Schilirò, T., Biorci, F., Romanazzi, V., Degan, R., Buonocore, D., Verri, M., Dossena, M., Bonetta, S. and Gilli, G., 2018. Physical activity, lifestyle factors and oxidative stress in middle age healthy subjects. International Journal of Environmental Research and Public Health 15: 1152. https://doi.org/10.3390/ijerph15061152
-
Chen, R.R., Fan, X.H., Chen, G., Zeng, G.W., Xue, Y.G., Liu, X.T. and Wang, C.Y., 2019. Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/TGFb1/Smad2/3 signaling axis. Chemico-Biological Interactions 302: 11-21. https://doi.org/10.1016/j.cbi.2019.01.031
-
Da Silveira, M.P., da Silva Fagundes, K.K., Bizuti, M.R., Starck, É., Rossi, R.C. and De Resende E Silva, D.T., 2021. Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature. Clinical and Experimental Medicine 21: 15-28. https://doi.org/10.1007/s10238-020-00650-3
-
Done, A.J. and Traustadóttir, T., 2016. Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study. Age 38: 505-512. https://doi.org/10.1007/s11357-016-9942-x
-
Done, A.J., Newell, M.J. and Traustadóttir, T., 2017. Effect of exercise intensity on Nrf2 signalling in young men. Free Radical Research 51: 646-655. https://doi.org/10.1080/10715762.2017.1353689
-
Duzova, H.K.Y., Emre, M.H., Dogan, Z.Y. and Kilinc, E., 2009. Effects of acute moderate and strenuous exercise bouts on il-17 production and inflammatory response in trained rats. Journal of Sports Science and Medicine 8: 219-224.
'Effects of acute moderate and strenuous exercise bouts on il-17 production and inflammatory response in trained rats ' () 8 Journal of Sports Science and Medicine : 219 -224.
-
Foster, C., Jackson, A.S., Pollock, M.L, Taylor, M.M., Hare, J., Sennett, S.M., Rod, J.L., Sarwar, M. and Schmidt, D.H., 1984. Generalized equations for predicting functional capacity from treadmill performance. American Heart Journal 107: 1229-1234. https://doi.org/10.1016/0002-8703(84)90282-5
-
Fukushi, T., Yamamoto, T., Yoshida, M., Fujikura, E., Miyazaki, M. and Nakayama, M., 2020. Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis. Scientific Reports 10: 21747. https://doi.org/10.1038/s41598-020-78742-z
-
Golbidi, S., Ebadi, A. and Laher, I., 2011. Antioxidants in the treatment of diabetes. Current Diabetes Reviews 7: 106-125. https://doi.org/10.2174/157339911794940729
-
Goutianos, G, Margaritelis, N.V., Sparopoulou, T., Veskoukis, A.S., Vrabas, I.S., Paschalis, V., Nikolaidis, M.G. and Kyparos, A., 2020. Chronic administration of plasma from exercised rats to sedentary rats does not induce redox and metabolic adaptations. Journal of Physiological Sciences 70: 3. https://doi.org/10.1186/s12576-020-00737-2
-
Greggio, C., Jha, P., Kulkarni, S.S., Lagarrigue, S., Broskey, N.T., Boutant, M., Wang, X., Conde Alonso, S., Ofori, E., Auwerx, J., Cantó, C. and Amati, F., 2017. enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metabolism 25: 301-311. https://doi.org/10.1016/j.cmet.2016.11.004
-
Groussard, C., Maillard, F., Vazeille, E., Barnich, N., Sirvent, P., Otero, Y.F., Combaret, L., Madeuf, E., Sourdrille, A., Delcros, G., Etienne, M., Teixeira, A., Sauvanet, P., Pialoux, V. and Boisseau, N., 2019. Tissue-specific oxidative stress modulation by exercise: a comparison between MICT and HIIT in an obese rat model. Oxidative Medicine and Cellular Longevity 2019: 1965364. https://doi.org/10.1155/2019/1965364
-
Holz, O., Roepcke, S., Watz, H., Tegtbur, U., Lahu, G. and Hohlfeld, J.M., 2015. Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD. International Journal of Chronic Obstructive Pulmonary Disease 10: 1393-1402. https://doi.org/10.2147/COPD.S83269
-
Huertas, J.R., Al Fazazi, S., Hidalgo-Gutierrez, A., López, L.C. and Casuso, R.A., 2017. Antioxidant effect of exercise: Exploring the role of the mitochondrial complex I superassembly. Redox Biology 13: 477-481. https://doi.org/10.1016/j.redox.2017.07.009
-
Isaacs, A.W., Macaluso, F., Smith, C. and Myburgh, K.H., 2019. C-Reactive Protein Is Elevated Only in high creatine kinase responders to muscle damaging exercise. Frontiers in Physiology 10: 86. https://doi.org/10.3389/fphys.2019.00086
-
Kawanishi, N., Mizokami, T., Niihara, H., Yada, K. and Suzuki, K., 2016. Neutrophil depletion attenuates muscle injury after exhaustive exercise. Medicine and Science in Sports and Exercise 48: 1917-1924. https://doi.org/10.1249/MSS.0000000000000980
-
Khan, A.A., Alsahli, M.A. and Rahmani, A.H., 2018. Myeloperoxidase as an active disease biomarker: recent biochemical and pathological perspectives. Medical Sciences 6: 33.https://doi.org/10.3390/medsci6020033
-
Kozakiewicz, M., Kornatowski, M., Krzywińska, O. and Kędziora-Kornatowska, K., 2019a. Changes in the blood antioxidant defense of advanced age people. Clinical Interventions in Aging 14: 763-771. https://doi.org/10.2147/CIA.S201250
-
Kozakiewicz, M., Rowiński, R., Kornatowski, M., Dąbrowski, A., Kędziora-Kornatowska, K. and Strachecka, A., 2019b. Relation of moderate physical activity to blood markers of oxidative stress and antioxidant defense in the elderly. Oxidative Medicine and Cellular Longevity 2019: 5123628. https://doi.org/10.1155/2019/5123628
-
Lee, J.H. and Jun, H.S., 2019. Role of myokines in regulating skeletal muscle mass and function. Frontiers in Physiology 10: 42. https://doi.org/10.3389/fphys.2019.00042
-
Louzada, R.A., Bouviere, J., Matta, L.P., Werneck-de-Castro, J.P., Dupuy, C., Carvalho, D.P. and Fortunato, R.S., 2020. Redox signaling in widespread health benefits of exercise. Antioxidants and Redox Signalling 33: 745-760. https://doi.org/10.1089/ars.2019.7949
-
Morozov, V.I., Tsyplenkov, P.V., Golberg, N.D. and Kalinski, M.I., 2006. The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats. European Journal of Applied Physiology 97: 716-722. https://doi.org/10.1007/s00421-006-0193-x
-
Nieman, D.C. and Wentz, L. M., 2019. The compelling link between physical activity and the body’s defense system. Journal of Sport and Health Science 8: 201-217. https://doi.org/10.1016/j.jshs.2018.09.009
-
Nocella, C., Cammisotto, V., Pigozzi, F., Borrione, P., Fossati, C., D’Amico, A., Cangemi, R., Peruzzi, M., Gobbi, G., Ettorre, E., Frati, G., Cavarretta, E., Carnevale, R. and SMiLe Group., 2019. Impairment between oxidant and antioxidant systems: short- and long-term implications for athletes’ health. Nutrients 11: 1353. https://doi.org/10.3390/nu11061353
-
Obermayer, A., Jakob, L.M., Haslbauer, J.D., Matter, M.S., Tzankov, A. and Stoiber, W., 2021. Neutrophil extracellular traps in fatal COVID-19-associated lung injury. Disease Markers 2021: 5566826. https://doi.org/10.1155/2021/5566826
-
Park, S.Y. and Kwak, Y.S., 2016. Impact of aerobic and anaerobic exercise training on oxidative stress and antioxidant defense in athletes. Journal of Exercise Rehabilitation 12: 113-117.https://doi.org/10.12965/jer.1632598.299
-
Popovic, L.M., Mitic, N.R., Miric, D., Bisevac, B., Miric, M. and Popovic B., 2015. Influence of vitamin C supplementation on oxidative stress and neutrophil inflammatory response in acute and regular exercise. Oxidative Medicine and Cellular Longevity 2015: 295497. https://doi.org/10.1155/2015/295497
-
Powers, S. K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M.P. and Hyatt, H., (2020). Exercise-induced oxidative stress: friend or foe? Journal of Sport and Health Science 9: 415-425. https://doi.org/10.1016/j.jshs.2020.04.001
-
Queensland Government, 2012. Queensland health guideline: exercise stress testing, version no. 1.0. Document Number # QH-GDL-392:2013, Queensland Government, Australia. Available at: https://tinyurl.com/238v79v8
-
Ramez, M., Ramezani, F., Nasirinezhad, F. and Rajabi, H., 2020. High-intensity interval training increases myocardial levels of Klotho and protects the heart against ischaemia-reperfusion injury. Experimental Physiology 105: 652-665. https://doi.org/10.1113/EP087994
-
Ren, M., Zhou, K., He, L. and Lin, W., 2018. Mitochondria and lysosome-targetable fluorescent probes for HOCl: recent advances and perspectives. Journal of Materials Chemistry B 6: 1716-1733. https://doi.org/10.1039/c7tb03337k
-
Rowiński, R., Kozakiewicz, M., Kędziora-Kornatowska, K., Hübner-Woźniak, E. and Kędziora, J., 2013. Markers of oxidative stress and erythrocyte antioxidant enzyme activity in older men and women with differing physical activity. Experimental Gerontology 48: 1141-1146. https://doi.org/10.1016/j.exger.2013.07.010
-
Seifi-Skishahr, F., Damirchi, A., Farjaminezhad, M. and Babaei, P., 2016. Physical training status determines oxidative stress and redox changes in response to an acute aerobic exercise. Biochemistry Research International 2016: 3757623. https://doi.org/10.1155/2016/3757623
-
Sellami, M., Gasmi, M., Denham, J., Hayes, L.D., Stratton, D., Padulo, J. and Bragazzi, N., 2018. Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging? Frontiers in Immunology 9: 2187. https://doi.org/10.3389/fimmu.2018.02187
-
Shields, H.J., Traa, A. and Van Raamsdonk, J.M., 2021. Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies. Frontiers in Cell and Developmental Biology 9: 628157. https://doi.org/10.3389/fcell.2021.628157
-
Syu, G.D., Chen, H.I. and Jen, C.J., 2011. Severe exercise and exercise training exert opposite effects on human neutrophil apoptosis via altering the redox status. PLoS ONE 6: e24385. https://doi.org/10.1371/journal.pone.0024385
-
Terra, R., da Silva, S.A.G., Pinto, V.S. and Dutra, P.M.L., 2012. Effect of exercise on the immune system: response, adaptation and cell signaling. Revista Brasileira de Medicina do Esporte 18: 208-214. https://doi.org/10.1590/S1517-86922012000300015
-
Thirupathi, A. and Pinho, R.A., 2018. Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles. Journal of Physiology and Biochemistry 74(3): 359-367. https://doi.org/10.1007/s13105-018-0633-1
-
Vida, C., Martinez de Toda, I., Garrido, A., Carro, E., Molina, J. A. and De la Fuente, M., 2018. Impairment of several immune functions and redox state in blood cells of alzheimer’s disease patients. Relevant role of neutrophils in oxidative stress. Frontiers in Immunology 8: 1974. https://doi.org/10.3389/fimmu.2017.01974
-
Vlasova, I.I., 2018. Peroxidase activity of human hemoproteins: keeping the fire under control. Molecules 23: 2561. https://doi.org/10.1016/j.redox.2019.101344
-
Vlasova, I.I., Sokolov, A.V., Kostevich, V.A., Mikhalchik, E.V. and Vasilyev, V.B., 2019. Myeloperoxidase induced oxidation of albumin and ceruloplasmin: role of tyrosines. Biochemistry Research International 84: 652-662. https://doi.org/10.1134/S0006297919060087
-
Williams, N., 2017. The Borg rating of perceived exertion (RPE) scale. Occupational Medicine 67: 404-405. https://doi.org/10.1093/occmed/kqx063
-
Ziemkiewicz, N., Hilliard, G., Pullen, N.A. and Garg, K., 2021. The role of innate and adaptive immune cells in skeletal muscle regeneration. International Journal of Molecular Sciences 22: 3265. https://doi.org/10.3390/ijms22063265
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 310 | 104 | 21 |
| Full Text Views | 24 | 0 | 0 |
| PDF Views & Downloads | 35 | 0 | 0 |
Leisure-time regular exercise and prevention of the side effects of immune system activity in middle-aged healthy subjects
In: Comparative Exercise PhysiologySearch for other papers by S.R. Rahimi Moghaddam in
Current site
Google Scholar
PubMed
Search for other papers by J. Mehrabani in
Current site
Google Scholar
PubMed
Search for other papers by H. Berahman in
Current site
Google Scholar
PubMed
Search for other papers by A. Elmieh in
Current site
Google Scholar
PubMed
Search for other papers by M.R. Fadaei Chafy in
Current site
Google Scholar
PubMed
Regular exercise is recommended to improve immune system function and antioxidant activity, while conversely, it may cause inflammation by increasing neutrophil-derived main enzyme, myeloperoxidase, which produces reactive oxygen species. The present study aimed to investigate changes in myeloperoxidase level, its influence on total oxidant status, and the capacity of the antioxidant defence system to counteract oxidative stress in middle-aged men participating in leisure-time regular exercise compared to untrained peer subjects. Twenty trained (age 53.58±2.94 years, body mass index (BMI) 25.47±1.6) and 17 untrained (age 54.17±2.83 years, BMI 27.83±1.12) healthy middle-aged men participated in this study [Rasht, Gilan, Iran]. Participants performed a modified Bruce treadmill test as a model of progressive exercise training. Blood samples were taken before, immediately after, and one hour after the end of the test. A mixed ANOVA and Bonferroni post hoc test was used for the analysis of variables. A significant difference was observed in myeloperoxidase levels between groups, while the trained group showed a significantly lower concentration than the untrained group (P<0.018). This result was also consistent with the lower total oxidant status in this group (P<0.001). Total antioxidant capacity changed significantly in both groups with higher concentration in the trained group (P<0.001). The leisure-time regular exercise can reduce myeloperoxidase concentration and total oxidant status in healthy middle-aged men while increasing the total antioxidant capacity, which may potentially protect them from the side effects of immune system activity induced by exercise training.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 310 | 104 | 21 |
| Full Text Views | 24 | 0 | 0 |
| PDF Views & Downloads | 35 | 0 | 0 |
