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Leisure-time regular exercise and prevention of the side effects of immune system activity in middle-aged healthy subjects
in Comparative Exercise PhysiologySearch for other papers by S.R. Rahimi Moghaddam in
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Regular exercise is recommended to improve immune system function and antioxidant activity, while conversely, it may cause inflammation by increasing neutrophil-derived main enzyme, myeloperoxidase, which produces reactive oxygen species. The present study aimed to investigate changes in myeloperoxidase level, its influence on total oxidant status, and the capacity of the antioxidant defence system to counteract oxidative stress in middle-aged men participating in leisure-time regular exercise compared to untrained peer subjects. Twenty trained (age 53.58±2.94 years, body mass index (BMI) 25.47±1.6) and 17 untrained (age 54.17±2.83 years, BMI 27.83±1.12) healthy middle-aged men participated in this study [Rasht, Gilan, Iran]. Participants performed a modified Bruce treadmill test as a model of progressive exercise training. Blood samples were taken before, immediately after, and one hour after the end of the test. A mixed ANOVA and Bonferroni post hoc test was used for the analysis of variables. A significant difference was observed in myeloperoxidase levels between groups, while the trained group showed a significantly lower concentration than the untrained group (P<0.018). This result was also consistent with the lower total oxidant status in this group (P<0.001). Total antioxidant capacity changed significantly in both groups with higher concentration in the trained group (P<0.001). The leisure-time regular exercise can reduce myeloperoxidase concentration and total oxidant status in healthy middle-aged men while increasing the total antioxidant capacity, which may potentially protect them from the side effects of immune system activity induced by exercise training.
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Leisure-time regular exercise and prevention of the side effects of immune system activity in middle-aged healthy subjects
in Comparative Exercise PhysiologySearch for other papers by S.R. Rahimi Moghaddam in
Current site
Google Scholar
PubMed
Search for other papers by J. Mehrabani in
Current site
Google Scholar
PubMed
Search for other papers by H. Berahman in
Current site
Google Scholar
PubMed
Search for other papers by A. Elmieh in
Current site
Google Scholar
PubMed
Search for other papers by M.R. Fadaei Chafy in
Current site
Google Scholar
PubMed
Regular exercise is recommended to improve immune system function and antioxidant activity, while conversely, it may cause inflammation by increasing neutrophil-derived main enzyme, myeloperoxidase, which produces reactive oxygen species. The present study aimed to investigate changes in myeloperoxidase level, its influence on total oxidant status, and the capacity of the antioxidant defence system to counteract oxidative stress in middle-aged men participating in leisure-time regular exercise compared to untrained peer subjects. Twenty trained (age 53.58±2.94 years, body mass index (BMI) 25.47±1.6) and 17 untrained (age 54.17±2.83 years, BMI 27.83±1.12) healthy middle-aged men participated in this study [Rasht, Gilan, Iran]. Participants performed a modified Bruce treadmill test as a model of progressive exercise training. Blood samples were taken before, immediately after, and one hour after the end of the test. A mixed ANOVA and Bonferroni post hoc test was used for the analysis of variables. A significant difference was observed in myeloperoxidase levels between groups, while the trained group showed a significantly lower concentration than the untrained group (P<0.018). This result was also consistent with the lower total oxidant status in this group (P<0.001). Total antioxidant capacity changed significantly in both groups with higher concentration in the trained group (P<0.001). The leisure-time regular exercise can reduce myeloperoxidase concentration and total oxidant status in healthy middle-aged men while increasing the total antioxidant capacity, which may potentially protect them from the side effects of immune system activity induced by exercise training.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 312 | 106 | 23 |
| Gesamttextansichten | 24 | 0 | 0 |
| PDF-Downloads | 35 | 0 | 0 |
