The present study investigated the effects of Bifidobacterium longum BB536 on lipid profile, liver and kidney function, and body fat in hypercholesterolaemic rats. 40 Sprague-Dawley rats were randomly divided into five groups. The negative control group received a standard diet. The positive control group received a cholesterol-enriched diet, whereas the intervention groups received a cholesterol-enriched diet supplemented with B. longum BB536 alone or in combination with inulin or Mangifera pajang fibrous polysaccharides. After 8 weeks, plasma lipids, and liver and kidney function were tested. Intake of the cholesterol-enriched diet increased total cholesterol, alanine aminotransferase, gamma-glutamyl transferase, creatinine, urea, liver weight, adipose tissue weight, liver lipid deposition and adipocyte size. B. longum BB536 supplementation significantly reduced total cholesterol, liver lipid deposition and adipocyte size, and positively affected liver and kidney function. These effects were significantly increased in the presence of inulin and M. pajang fibrous polysaccharides.
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Abdel-Baset, H., Omar, E., Samar, H., Fathy, A.Y. and Hafez, A., 1997. Biochemical effect of antioxidants on lipids and liver function in experimentally induced liver damage. Annals of Clinical Biochemistry 34: 656-663.
'Biochemical effect of antioxidants on lipids and liver function in experimentally induced liver damage ' () 34 Annals of Clinical Biochemistry : 656 -663.
American Institute of Nutrition, 1977. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. Journal of Nutrition 107: 1340-1348.
Akalin, A.S., Gönc, S. and Düzel, S., 1997. Influence of yogurt and acidophilus yogurt on serum cholesterol levels in mice. Journal of Dairy Science 80: 2721-2725.
'Influence of yogurt and acidophilus yogurt on serum cholesterol levels in mice ' () 80 Journal of Dairy Science : 2721 -2725.
Al-Sheraji, S.H., Ismail, A., Manap, M.Y., Mustafa, S., Yusof, R.M. and Hassan, F.A., 2011. Functional properties and characterization of dietary fiber from Mangifera pajang Kort. fruit pulp. Journal of Agricultural and Food Chemistry 59: 3980-3985.
'Functional properties and characterization of dietary fiber from Mangifera pajang Kort. fruit pulp ' () 59 Journal of Agricultural and Food Chemistry : 3980 -3985.
Al-Sheraji, S.H., Ismail, A., Manap, M.Y., Mustafa, S. and Yusuf, R.M., 2012c. Survival and activity of bifidobacteria during refrigerated storage of yoghurt containing Mangifera pajang fibres polysaccharides. Journal of Food Science 77: M624-M630.
'Survival and activity of bifidobacteria during refrigerated storage of yoghurt containing Mangifera pajang fibres polysaccharides ' () 77 Journal of Food Science : M624 -M630.
Al-Sheraji, S.H., Ismail, A., Manap, M.Y., Mustafa, S., Yusof, R.M. and Hassan, F.A., 2012a. Purification, characterization and antioxidant activity of polysaccharides extracted from the fibrous pulp of Mangifera pajang fruits. Food Science and Technology 48: 291-296.
'Purification, characterization and antioxidant activity of polysaccharides extracted from the fibrous pulp of Mangifera pajang fruits ' () 48 Food Science and Technology : 291 -296.
Al-Sheraji, S.H., Ismail, A., Manap, M.Y., Mustafa, S., Yusuf, R.M. and Hassan, F.A., 2012b. Fermentation and non-digestibility of Mangifera pajang fibrous pulp and its polysaccharide. Journal of Functional Foods 4: 933-940.
'Fermentation and non-digestibility of Mangifera pajang fibrous pulp and its polysaccharide ' () 4 Journal of Functional Foods : 933 -940.
Al-Sheraji, S.H., Ismail, A., Manap, M.Y., Mustafa, S., Yusuf, R.M. and Hassan, F.A., 2012d. Hypocholesterolaemic effect of yoghurt containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536. Food Chemistry 135: 356-361.
'Hypocholesterolaemic effect of yoghurt containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536 ' () 135 Food Chemistry : 356 -361.
Bondy, S.C., Lam, H.R., Ostergard, G., Guo, S.X. and Ladefoged, O., 1995. Changes in markers of oxidative status in brain, liver and kidney of young and aged rats following exposure to aromatic white spirit. Archives of Toxicology 69: 410-414.
'Changes in markers of oxidative status in brain, liver and kidney of young and aged rats following exposure to aromatic white spirit ' () 69 Archives of Toxicology : 410 -414.
Chae, J.P., Valeriano, V.D., Kim, G.-B. and Kang, D.-K., 2012. Molecular cloning, characterization and comparison of bile salt hydrolases from Lactobacillus johnsonii PF01. Journal of Applied Microbiology 114: 121-133.
'Molecular cloning, characterization and comparison of bile salt hydrolases from Lactobacillus johnsonii PF01 ' () 114 Journal of Applied Microbiology : 121 -133.
Champagne, C.P., Raymond, Y. and Tompkins, T.A., 2010. The determination of viable counts in probiotic cultures microencapsulated by spray-coating. Food Microbiology 27: 1104-1111.
'The determination of viable counts in probiotic cultures microencapsulated by spray-coating ' () 27 Food Microbiology : 1104 -1111.
Chiu, C., Lu, T., Tseng, Y. and Pan, T., 2006. The effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet. Applied Microbiology and Biotechnology 71: 238-245.
'The effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet ' () 71 Applied Microbiology and Biotechnology : 238 -245.
Diaz, M.A., Bik, E.M., Carlin, K.P., Venn-Watson, S.K., Jensen, E.D., Jones, S.E., Gaston, E.P., Relman, D.A. and Versalovic, J., 2013. Identification of Lactobacillus strains with probiotic features from the bottlenose dolphin (Tursiops truncatus). Journal of Applied Microbiology 115:1037-1051.
'Identification of Lactobacillus strains with probiotic features from the bottlenose dolphin (Tursiops truncatus) ' () 115 Journal of Applied Microbiology : 1037 -1051.
El-Gawad, I.A., El-Sayed, E.M., Hafez, S.A., El-Zeini, H.M. and Saleh, F.A., 2005. The hypocholesterolemic effect of milk yoghurt and soy-yoghurt containing bifidobacteria in rats fed on a cholesterol-enriched diet. International Dairy Journal 15: 37-44.
'The hypocholesterolemic effect of milk yoghurt and soy-yoghurt containing bifidobacteria in rats fed on a cholesterol-enriched diet ' () 15 International Dairy Journal : 37 -44.
Endres, J.R., Clewell, A., Jade, K.A., Farber, T., Hauswirth, J. and Schauss A.G., 2009. Safety assessment of a proprietary preparation of a novel probiotic, Bacillus coagulans, as a food ingredient. Food and Chemical Toxicology 47: 1231-1238.
'Safety assessment of a proprietary preparation of a novel probiotic, Bacillus coagulans, as a food ingredient ' () 47 Food and Chemical Toxicology : 1231 -1238.
Endres, J.R., Qureshi, I., Farber, T., Hauswirth, J., Hirka, G., Pasics, I. and Schauss, A.G., 2011. One-year chronic oral toxicity with combined reproduction toxicity study of a novel probiotic, Bacillus coagulans, as a food ingredient. Food and Chemical Toxicology 49: 1174-1182.
'One-year chronic oral toxicity with combined reproduction toxicity study of a novel probiotic, Bacillus coagulans, as a food ingredient ' () 49 Food and Chemical Toxicology : 1174 -1182.
Fernandez, B., Le Lay, C., Jean J. and Fliss, I., 2013. Growth, acid production and bacteriocin production by probiotic candidates under simulated colonic conditions. Journal of Applied Microbiology 114: 877-885.
'Growth, acid production and bacteriocin production by probiotic candidates under simulated colonic conditions ' () 114 Journal of Applied Microbiology : 877 -885.
Gomez, E., Tuohy, K.M., Gibson, G.R., Klinder, A. and Costabile, A., 2010. In vitro evaluation of the fermentation properties and potential prebiotic activity of Agave fructans. Journal of Applied Microbiology 108: 2114-2121.
'In vitro evaluation of the fermentation properties and potential prebiotic activity of Agave fructans ' () 108 Journal of Applied Microbiology : 2114 -2121.
Hassan, F.A., Ismail, A., Abdul Hamid, A., Azlan, A. and Al-sheraji, S.H., 2011b. Characterisation of fibre-rich powder and antioxidant capacity of Mangifera pajang K. fruit peels. Food Chemistry 126: 283-288.
'Characterisation of fibre-rich powder and antioxidant capacity of Mangifera pajang K. fruit peels ' () 126 Food Chemistry : 283 -288.
Hassan, F.A., Ismail, A., Abdulhamid, A. and Azlan, A., 2011a. Identification and quantification of phenolic compounds in bambangan (Mangifera pajang Kort.) peels and their free radical scavenging activity. Journal of Agricultural and Food Chemistry 59: 9102-9111.
'Identification and quantification of phenolic compounds in bambangan (Mangifera pajang Kort.) peels and their free radical scavenging activity ' () 59 Journal of Agricultural and Food Chemistry : 9102 -9111.
Homma, N., 1988. Bifidobacteria as a resistance factor in human beings. Bifidobacteria and Microflora 7: 35-43.
'Bifidobacteria as a resistance factor in human beings ' () 7 Bifidobacteria and Microflora : 35 -43.
Huang, Y., Kotula, L. and Adams, M.C., 2003. The in vivo assessment of safety and gastrointestinal survival of an orally administered novel probiotic, Propionibacterium jensenii 702, in a male Wistar rat model. Food and Chemical Toxicology 41: 1781-1787.
'The in vivo assessment of safety and gastrointestinal survival of an orally administered novel probiotic, Propionibacterium jensenii 702, in a male Wistar rat model ' () 41 Food and Chemical Toxicology : 1781 -1787.
Kailasapathy, K. and Rybka, S., 1997. Lactobacillus acidophilus and Bifidobacterium spp. their therapeutic potential and survival in yoghurt. Australian Journal of Dairy Technology 52: 28-35.
'Lactobacillus acidophilus and Bifidobacterium spp. their therapeutic potential and survival in yoghurt ' () 52 Australian Journal of Dairy Technology : 28 -35.
Kannel, W.B., Castelli, W.P., Gordon. T. and McNamara, P.M., 1971. Serum cholesterol, lipoproteins and the risk of coronary heart disease: the Framingham study. Annals of Internal Medicine 74: 1-12.
'Serum cholesterol, lipoproteins and the risk of coronary heart disease: the Framingham study ' () 74 Annals of Internal Medicine : 1 -12.
Kiessling, G., Schneider, J. and Jahreis, G., 2002. Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol. European Journal of Clinical Nutrition 56: 843-849.
'Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol ' () 56 European Journal of Clinical Nutrition : 843 -849.
Kurmann, J.A. and Rasic, J.L., 1991. The health potential of products containing bifidobacteria. In: Robinson, R.K. (ed.) Therapeutic properties of fermented milks. Elsevier Applied Science Publishers, London, UK, pp. 117-158.
'The health potential of products containing bifidobacteria ', in Therapeutic properties of fermented milks , () 117 -158.
Liong, M.T. and Shah, N.P., 2005. Acid and bile tolerance and cholesterol removal ability of lactobacilli strains. Journal of Dairy Science 88: 55-66.
'Acid and bile tolerance and cholesterol removal ability of lactobacilli strains ' () 88 Journal of Dairy Science : 55 -66.
Lourens-Hattingh, A. and Viljoen, C.B., 2001. Yoghurt as probiotic carrier food. International Dairy Journal 11: 1-17.
'Yoghurt as probiotic carrier food ' () 11 International Dairy Journal : 1 -17.
Mann, G.V. and Spoerry, A., 1974. Studies of a surfactant and cholesterolemia in the Maasai. American Journal of Clinical Nutrition 27: 464-469.
'Studies of a surfactant and cholesterolemia in the Maasai ' () 27 American Journal of Clinical Nutrition : 464 -469.
McIntyre, N. and Rosalki, 1992. Biochemical investigation in the management of liver disease. In: Prieto, J., Rodes J. and Shafritz, D.A. (eds.) Hepatobiliary diseases. Springer Verlag, Berlin, Germany, pp. 39-71.
'Biochemical investigation in the management of liver disease ', in Hepatobiliary diseases , () 39 -71.
Naito, E., Yoshida, Y., Makino, K., Kounoshi, Y., Kunihiro, S., Takahashi, R., Matsuzaki, T., Miyazaki, K. and Ishikawa, F., 2011. Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice. Journal of Applied Microbiology 110: 650-657.
'Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice ' () 110 Journal of Applied Microbiology : 650 -657.
O’Neill, J., 2008. The lifelong benefits of inulin and oligofructose. Cereal Food World 53: 65-68.
'The lifelong benefits of inulin and oligofructose ' () 53 Cereal Food World : 65 -68.
Schaarmann, G., Schneider, J., Zorn, A., Vilser, C. and Jahreis, G., 2001. Influence of probiotic yoghurt on serum lipids in women. American Journal of Clinical Nutrition 73: 496S.
'Influence of probiotic yoghurt on serum lipids in women ' () 73 American Journal of Clinical Nutrition : 496S.
Seelig, A. and Seelig, J., 1996. Interaction of drugs and peptides with the lipid membrane. In: Schwartz, T., Hijorth, S.A. and Kastrup, J.S. (eds.) Alfred Benzon Symposium 39 ‘Structure and function of 7TM receptors’, Muntsgaard, Copenhagen, Denmark, pp. 184-193.
'Interaction of drugs and peptides with the lipid membrane ' , , .
Takemura, N., Okubo, T. and Sonoyama, K., 2010. Lactobacillus plantarum strain no. 14 reduces adipocyte size in mice fed high-fat diet. Experimental Biology and Medicine 235: 849-856.
'Lactobacillus plantarum strain no. 14 reduces adipocyte size in mice fed high-fat diet ' () 235 Experimental Biology and Medicine : 849 -856.
Talwalkar, A. and Kailasapathy, K., 2004. A review of oxygen toxicity in probiotic yogurts: influence on the survival of probiotic bacteria and protective techniques. Comprehensive Reviews in Food Science and Food Safety 3: 117-124.
'A review of oxygen toxicity in probiotic yogurts: influence on the survival of probiotic bacteria and protective techniques ' () 3 Comprehensive Reviews in Food Science and Food Safety : 117 -124.
Trinder, P., 1969. Determination of blood glucose using 4-aminophenazone as oxygen acceptor. Journal of Clinical Pathology 22: 246.
'Determination of blood glucose using 4-aminophenazone as oxygen acceptor ' () 22 Journal of Clinical Pathology : 246.
Watson, D., O’Connell Motherway, M., Schoterman, M.H., Van Neerven, R.J., Nauta, A. and Van Sinderen D., 2013. Selective carbohydrate utilization by lactobacilli and bifidobacteria. Journal of Applied Microbiology 114: 1132-1146.
'Selective carbohydrate utilization by lactobacilli and bifidobacteria ' () 114 Journal of Applied Microbiology : 1132 -1146.
Xie, N., Cui,Y., Yin, Y., Zhao, X., Yang, J., Wang, Z.G., Fu, N., Tang, Y., Wang, X.H., Liu, X.W., Wang, C.L. and Lu, F.G., 2011. Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet. BMC Complementary and Alternative Medicine 11: 53-64.
'Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet ' () 11 BMC Complementary and Alternative Medicine : 53 -64.
Yin, Y., Yu, Q., Fu, N., Liu, X. and Lu, F., 2010. Effects of four bifidobacteria on obesity in high-fat diet induced rats. World Journal of Gastroenterology 16: 3394-3401.
'Effects of four bifidobacteria on obesity in high-fat diet induced rats ' () 16 World Journal of Gastroenterology : 3394 -3401.
Zhou, J.S., Shu, Q., Rutherfurd, K.J., Prasad J., Gopal, P.K. and Gill, H.S, 2000. Acute oral toxicity and bacterial translocation studies on potentially probiotic strains of lactic acid bacteria. Food and Chemical Toxicology 38: 153-161
'Acute oral toxicity and bacterial translocation studies on potentially probiotic strains of lactic acid bacteria ' () 38 Food and Chemical Toxicology : 153 -161.
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The present study investigated the effects of Bifidobacterium longum BB536 on lipid profile, liver and kidney function, and body fat in hypercholesterolaemic rats. 40 Sprague-Dawley rats were randomly divided into five groups. The negative control group received a standard diet. The positive control group received a cholesterol-enriched diet, whereas the intervention groups received a cholesterol-enriched diet supplemented with B. longum BB536 alone or in combination with inulin or Mangifera pajang fibrous polysaccharides. After 8 weeks, plasma lipids, and liver and kidney function were tested. Intake of the cholesterol-enriched diet increased total cholesterol, alanine aminotransferase, gamma-glutamyl transferase, creatinine, urea, liver weight, adipose tissue weight, liver lipid deposition and adipocyte size. B. longum BB536 supplementation significantly reduced total cholesterol, liver lipid deposition and adipocyte size, and positively affected liver and kidney function. These effects were significantly increased in the presence of inulin and M. pajang fibrous polysaccharides.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 579 | 242 | 24 |
| Full Text Views | 22 | 12 | 0 |
| PDF Views & Downloads | 22 | 19 | 0 |