Effect of feed contaminants on intestinal health of monogastric farm animals

I. Alassane-Kpembi; I.P. Oswald

Effect of feed contaminants on intestinal health of monogastric farm animals

于Intestinal health

著者：

I. Alassane-Kpembi

I. Alassane-Kpembi ¹INRA, UMR 1331, Toxalim, Research centre in Food Toxicology, 31027 Toulouse, France
²Université de Toulouse, INP, UMR 1331, Toxalim, 31027 Toulouse, France
³Hôpital d’Instruction des Armées, Camp Guézo 01BP517 Cotonou, Bénin; iakpembi@gmail.com, isabelle.oswald@toulouse.inra.fr

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I.P. Oswald

I.P. Oswald ¹INRA, UMR 1331, Toxalim, Research centre in Food Toxicology, 31027 Toulouse, France
²Université de Toulouse, INP, UMR 1331, Toxalim, 31027 Toulouse, France

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类型:: 章节

Page Range:: 169–190

DOI:: https://doi.org/10.3920/9789086867929_009

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As the most extensively exposed surface in the body, the intestinal mucosa has to face important chemical and biological challenges. The intestinal mucosa has three main physiological functions. It establishes a physical barrier between the internal milieu and the luminal content. The intestinal mucosa is also responsible for luminal nutrients digestion and their subsequent absorption. The mucosal epithelium is at the interface of immune system and luminal contents, including dietary antigens and microbial products. This implies a local defence mechanisms regulation that involves integrating all the signals that come from the external and internal world to preserve immune homeostasis steady-state conditions. Either of these intestinal physiological functions may be targeted by feed contaminants. These contaminants may be naturally occurring compounds or substances from anthropogenic sources. In the present chapter, we present mycotoxins and dioxins, which are representative examples of both classes of contaminants. Data gathered show clearly that dietary exposure to realistic doses of these contaminants impairs intestine functionality and its integrity as well. The mechanisms of action of mycotoxins and dioxins targeting the gastrointestinal tract are clarified and evidences for their deleterious effects for monogastrics intestinal health are provided.

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Intestinal health

Key to maximise growth performance in livestock

ISBN:: 9789086867929

出版社:: Wageningen Academic

印刷出版日期:: 15 Nov 2015

Subjects
- Life Sciences
  - General
  - Animal & Veterinary

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Effect of feed contaminants on intestinal health of monogastric farm animals

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Intestinal health

Key to maximise growth performance in livestock

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