Chairs of the Assembly of the African Union, 2021
| Feb. 2020–Feb. 2021 | Cyril Ramaphosa (South Africa) |
| Feb. 2021–Feb. 2022 | Félix Antoine Tshisekedi (DRC) |
Chairperson of the AU Commission and Commissioners, 2021
| Chairperson | since Mar. 2017 | Moussa Faki Mahama (Chad) |
| Deputy Chairperson | since Feb. 2021 | Monique Nsanzabaganwa (Rwanda) |
| Commissioner for Political Affairs, Peace and Security | since Feb. 2021 | Bankole A. Adeoye (Nigeria) |
| Commissioner for Infrastructure and Energy | since Jan. 2017 | Amani Abou-Zeid (Egypt) |
| Commissioner for Economic Development, Trade, Industry and Mining | since Jan. 2017 | Albert M. Muchanga (Zambia) |
| Commissioner for Agriculture, Rural Development, Blue Economy and Sustainable Environment | since Jan. 2017 | Josefa Leonel Correa Sacko (Angola) |
| Commissioner for Health, Humanitarian Affairs and Social Development | Jul. 2017–Jul. 2021 | Amira Elfadil Mohammed (Sudan) |
| since Jul. 2021 | Minata Samate Cessouma (Burkina Faso) | |
| Commissioner for Education, Science, Technology and Innovation | Jul. 2017–Oct. 2021 | Sarah Anyang Agbor (Cameroon) |
| Oct. 2021* | Belhocine Mohammed (Algeria) |
Official handover ceremony only in Jan. 2022
| Central Africa | Burundi | 2019–2022 | |
| Cameroon | 2020–2022 | ||
| Chad | 2020–2022 | ||
| East Africa | Kenya | 2019–2022 | |
| Djibouti | 2020–2022 | ||
| Ethiopia | 2020–2022 | ||
| North Africa | Algeria | 2019–2022 | |
| Egypt | 2020–2022 | ||
| Southern Africa | Lesotho | 2019–2022 | |
| Malawi | 2020–2022 | ||
| Mozambique | 2020–2022 | ||
| West Africa | Nigeria | 2019–2022 | |
| Benin | 2020–2022 | ||
| Ghana | 2020–2022 | ||
| Senegal | 2020–2022 |
Members of the Panel of the Wise, 2021
| Central Africa | since Jul. 2017 | Honorine Nzet Bitéghé (Gabon) |
| East Africa | since Jun. 2014 | Speciosa Wandira Kazibwe (Uganda) |
| North Africa | since Jul. 2017 | Amr Moussa (Egypt) |
| Southern Africa | since Jul. 2017 | Hifikepunye Pohamba (Namibia) |
| West Africa | since Jul. 2017 | Ellen Johnson Sirleaf (Liberia) |
Note: All three-year terms of office have expired in 2020. Members are eligible for reappointment only once.