BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?
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2Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
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2Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
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5Department of Medicine, University College Cork, Clinical Sciences Building, Cork, Ireland
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3Department of Anatomy, University College Cork, Windle Building, Cork, Ireland
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4Department of Psychiatry, University College Cork, Cork University Hospital, Cork, Ireland
t.dinan@ucc.ie
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Abstract
Brain-derived neurotrophic factor (BDNF) is of interest because of its putative role in stress and psychiatric disorders. Maternal separation is used as an animal model of early-life stress and of irritable bowel syndrome (IBS). Animals exposed to the paradigm show altered gut function together with heightened levels of arousal and corticosterone. Some probiotic organisms have been shown to be of benefit in IBS and influence the brain-gut axis. Our objective was to investigate the effects of maternal separation on BDNF under basal conditions and in response to the probiotic Bifidobacterium breve 6330. The study implemented the maternal separation model which we have previously described. Polymerase chain reaction and in situ hybridisation were performed to measure the effect of maternal separation on both BDNF total variants and BDNF splice variant (exon) IV in the hippocampus. Maternally separated and non-separated rats were treated with B. breve 6330, to investigate the effect of this probiotic on BDNF total variant and BDNF exon IV expression. Maternal separation increased BDNF total variants (P<0.01), whilst having no effect on BDNF exon IV. B. breve 6330 increased BDNF total variants (P<0.01), and decreased BDNF splice variant IV, in non-separated rats (P<0.01). B. breve 6330 did not alter BDNF levels in the maternally separated rats. Maternal separation caused a marked increase in BDNF in the hippocampus. While B. breve 6330 influenced BDNF in normal animals, it had no significant effect on BDNF in those which were maternally separated. We have demonstrated that an orally administered probiotic can influence hippocampal BDNF.
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Aid, T., Kazantseva, A., Piirsoo, M., Palm, K. and Timmusk, T., 2007. Mouse and rat BDNF gene structure and expression revisited. Journal of Neuroscience Research 85: 525-535.
'Mouse and rat BDNF gene structure and expression revisited ' () 85 Journal of Neuroscience Research : 525 -535.
-
Aisa, B., Elizalde, N., Tordera, R., Lasheras, B., Del Rio, J. and Ramirez, M.J., 2009. Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: implications for spatial memory. Hippocampus 19: 1222-1231.
'Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: implications for spatial memory ' () 19 Hippocampus : 1222 -1231.
-
Arborelius, L., Hawks, B.W., Owens, M.J., Plotsky, P.M. and Nemeroff, C.B., 2004. Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation. Psychopharmacology (Berl) 176: 248-255.
'Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation ' () 176 Psychopharmacology (Berl) : 248 -255.
-
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K.D., Verdu, E.F. and Collins, S.M., 2011. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141: 599-609 e593.
-
Berninger, B., Schinder, A.F. and Poo, M.M., 1999. Synaptic reliability correlates with reduced susceptibility to synaptic potentiation by brain-derived neurotrophic factor. Learning and Memory 6: 232-242.
'Synaptic reliability correlates with reduced susceptibility to synaptic potentiation by brain-derived neurotrophic factor ' () 6 Learning and Memory : 232 -242.
-
Biagini, G., Pich, E.M., Carani, C., Marrama, P. and Agnati, L.F., 1998. Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field. International Journal of Developmental Neuroscience 16: 187-197.
'Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field ' () 16 International Journal of Developmental Neuroscience : 187 -197.
-
Bolanos, C.A. and Nestler, E.J., 2004. Neurotrophic mechanisms in drug addiction. Neuromolecular Medicine 5: 69-83.
'Neurotrophic mechanisms in drug addiction ' () 5 Neuromolecular Medicine : 69 -83.
-
Bravo, J.A., Dinan, T.G. and Cryan, J.F., 2011. Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. International Journal of Neuropsychopharmacology 14: 666-683.
'Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders ' () 14 International Journal of Neuropsychopharmacology : 666 -683.
-
Bremner, J.D., Narayan, M., Anderson, E.R., Staib, L.H., Miller, H.L. and Charney, D.S., 2000. Hippocampal volume reduction in major depression. The American Journal of Psychiatry 157: 115-118.
'Hippocampal volume reduction in major depression ' () 157 The American Journal of Psychiatry : 115 -118.
-
Brunson, K.L., Chen, Y., Avishai-Eliner, S. and Baram, T.Z., 2003. Stress and the developing hippocampus: a double-edged sword? Molecular Neurobiology 27: 121-136.
'Stress and the developing hippocampus: a double-edged sword ' () 27 Molecular Neurobiology : 121 -136.
-
Buwalda, B., Kole, M.H., Veenema, A.H., Huininga, M., De Boer, S.F., Korte, S.M. and Koolhaas, J.M., 2005. Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning. Neuroscience and Biobehavioral Reviews 29: 83-97.
'Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning ' () 29 Neuroscience and Biobehavioral Reviews : 83 -97.
-
Clarke, G., O'Mahony, S.M., Hennessy, A.A., Ross, P., Stanton, C., Cryan, J.F. and Dinan, T.G., 2009. Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood. Behavioural Brain Research 205: 319-321.
'Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood ' () 205 Behavioural Brain Research : 319 -321.
-
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J.F. and Dinan, T.G., 2010. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 170: 1179-1188.
'Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression ' () 170 Neuroscience : 1179 -1188.
-
Duman, R.S., 2002. Pathophysiology of depression: the concept of synaptic plasticity. European Psychiatry 17 Suppl. 3: 306-310.
-
Duman, R.S. and Monteggia, L.M., 2006. A neurotrophic model for stress-related mood disorders. Biological Psychiatry 59: 1116-1127.
'A neurotrophic model for stress-related mood disorders ' () 59 Biological Psychiatry : 1116 -1127.
-
Duman, R.S., Heninger, G.R. and Nestler, E.J., 1997. A molecular and cellular theory of depression. Archives of General Psychiatry 54: 597-606.
'A molecular and cellular theory of depression ' () 54 Archives of General Psychiatry : 597 -606.
-
Ghosh, A., Carnahan, J. and Greenberg, M.E., 1994. Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263: 1618-1623.
'Requirement for BDNF in activity-dependent survival of cortical neurons ' () 263 Science : 1618 -1623.
-
Greisen, M.H., Altar, C.A., Bolwig, T.G., Whitehead, R. and Wortwein, G., 2005. Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats. Journal of Neuroscience Research 79: 772-778.
'Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats ' () 79 Journal of Neuroscience Research : 772 -778.
-
Huang, E.J. and Reichardt, L.F., 2001. Neurotrophins: roles in neuronal development and function. Annual Review of Neuroscience 24: 677-736.
'Neurotrophins: roles in neuronal development and function ' () 24 Annual Review of Neuroscience : 677 -736.
-
Huang, E.J. and Reichardt, L.F., 2003. Trk receptors: roles in neuronal signal transduction. Annual Review of Biochemistry 72: 609-642.
'Trk receptors: roles in neuronal signal transduction ' () 72 Annual Review of Biochemistry : 609 -642.
-
Huot, R.L., Plotsky, P.M., Lenox, R.H. and McNamara, R.K., 2002. Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats. Brain Research Reviews 950: 52-63.
'Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats ' () 950 Brain Research Reviews : 52 -63.
-
Hyland, N.P., Julio-Pieper, M., O'Mahony, S.M., Bulmer, D.C., Lee, K., Quigley, E.M., Dinan, T.G. and Cryan, J.F., 2009. A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity? Gut 58: 1029.
-
Jaworska, N., Dwyer, S.M. and Rusak, B., 2008. Repeated neonatal separation results in different neurochemical and behavioral changes in adult male and female Mongolian gerbils. Pharmacology Biochemistry and Behavior 88: 533-541.
'Repeated neonatal separation results in different neurochemical and behavioral changes in adult male and female Mongolian gerbils ' () 88 Pharmacology Biochemistry and Behavior : 533 -541.
-
Korte, M., Kang, H., Bonhoeffer, T. and Schuman, E., 1998. A role for BDNF in the late-phase of hippocampal long-term potentiation. Neuropharmacology 37: 553-559.
'A role for BDNF in the late-phase of hippocampal long-term potentiation ' () 37 Neuropharmacology : 553 -559.
-
Ladd, C.O., Huot, R.L., Thrivikraman, K.V., Nemeroff, C.B., Meaney, M.J. and Plotsky, P.M., 2000. Long-term behavioral and neuroendocrine adaptations to adverse early experience. Progress in Brain Research 122: 81-103.
'Long-term behavioral and neuroendocrine adaptations to adverse early experience ' () 122 Progress in Brain Research : 81 -103.
-
Ladd, C.O., Huot, R.L., Thrivikraman, K.V., Nemeroff, C.B. and Plotsky, P.M., 2004. Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biological Psychiatry 55: 367-375.
'Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation ' () 55 Biological Psychiatry : 367 -375.
-
Ladd, C.O., Owens, M.J. and Nemeroff, C.B., 1996. Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation. Endocrinology 137: 1212-1218.
'Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation ' () 137 Endocrinology : 1212 -1218.
-
Law, A.J., Pei, Q., Walker, M., Gordon-Andrews, H., Weickert, C.S., Feldon, J., Pryce, C.R. and Harrison, P.J., 2009. Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder. Neuropsychopharmacology 34: 1381-1394.
'Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder ' () 34 Neuropsychopharmacology : 1381 -1394.
-
Lee, R., Kermani, P., Teng, K.K. and Hempstead, B.L., 2001. Regulation of cell survival by secreted proneurotrophins. Science 294: 1945-1948.
'Regulation of cell survival by secreted proneurotrophins ' () 294 Science : 1945 -1948.
-
Lee, T.H., Kato, H., Chen, S.T., Kogure, K. and Itoyama, Y., 2002. Expression disparity of brain-derived neurotrophic factor immunoreactivity and mRNA in ischemic hippocampal neurons. Neuroreport 13: 2271-2275.
'Expression disparity of brain-derived neurotrophic factor immunoreactivity and mRNA in ischemic hippocampal neurons ' () 13 Neuroreport : 2271 -2275.
-
Lippmann, M., Bress, A., Nemeroff, C.B., Plotsky, P.M. and Monteggia, L.M., 2007. Long-term behavioural and molecular alterations associated with maternal separation in rats. European Journal of Neuroscience 25: 3091-3098.
'Long-term behavioural and molecular alterations associated with maternal separation in rats ' () 25 European Journal of Neuroscience : 3091 -3098.
-
Liu, D., Diorio, J., Day, J.C., Francis, D.D. and Meaney, M.J., 2000. Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nature Neuroscience 3: 799-806.
'Maternal care, hippocampal synaptogenesis and cognitive development in rats ' () 3 Nature Neuroscience : 799 -806.
-
Logan, A.C. and Katzman, M., 2005. Major depressive disorder: probiotics may be an adjuvant therapy. Medical Hypotheses 64: 533-538.
'Major depressive disorder: probiotics may be an adjuvant therapy ' () 64 Medical Hypotheses : 533 -538.
-
Lu, J., Wu, Y., Sousa, N. and Almeida, O.F., 2005. SMAD pathway mediation of BDNF and TGF beta 2 regulation of proliferation and differentiation of hippocampal granule neurons. Development 132: 3231-3242.
'SMAD pathway mediation of BDNF and TGF beta 2 regulation of proliferation and differentiation of hippocampal granule neurons ' () 132 Development : 3231 -3242.
-
Magarinos, A.M., McEwen, B.S., Flugge, G. and Fuchs, E., 1996. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. The Journal of Neuroscience 16: 3534-3540.
'Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews ' () 16 The Journal of Neuroscience : 3534 -3540.
-
Mayer, E.A., Tillisch, K. and Bradesi, S., 2006. Modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease. Alimentary Pharmacology and Therapeutics 24: 919-933.
'Modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease ' () 24 Alimentary Pharmacology and Therapeutics : 919 -933.
-
McDonald, N.Q. and Hendrickson, W.A., 1993. A structural superfamily of growth factors containing a cystine knot motif. Cell 73: 421-424.
'A structural superfamily of growth factors containing a cystine knot motif ' () 73 Cell : 421 -424.
-
McIntosh, J., Anisman, H. and Merali, Z., 1999. Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects. Brain Research: Developmental Brain Research 113: 97-106.
'Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects ' () 113 Brain Research: Developmental Brain Research : 97 -106.
-
Mirescu, C. and Gould, E., 2006. Stress and adult neurogenesis. Hippocampus 16: 233-238.
'Stress and adult neurogenesis ' () 16 Hippocampus : 233 -238.
-
Moayyedi, P., Ford, A.C., Talley, N.J., Cremonini, F., Foxx-Orenstein, A.E., Brandt, L.J. and Quigley, E.M., 2010. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut 59: 325-332.
'The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review ' () 59 Gut : 325 -332.
-
Molteni, R., Calabrese, F., Cattaneo, A., Mancini, M., Gennarelli, M., Racagni, G. and Riva, M.A., 2008. Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine. Neuropsychopharmacology 34: 1523-1532.
'Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine ' () 34 Neuropsychopharmacology : 1523 -1532.
-
Nair, A., Vadodaria, K.C., Banerjee, S.B., Benekareddy, M., Dias, B.G., Duman, R.S. and Vaidya, V.A., 2007. Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Neuropsychopharmacology 32: 1504-1519.
'Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus ' () 32 Neuropsychopharmacology : 1504 -1519.
-
Nawa, H., Takahashi, M. and Patterson, P.H., 2000. Cytokine and growth factor involvement in schizophrenia – support for the developmental model. Molecular Psychiatry 5: 594-603.
'Cytokine and growth factor involvement in schizophrenia – support for the developmental model ' () 5 Molecular Psychiatry : 594 -603.
-
O'Mahony, S.M., Hyland, N.P., Dinan, T.G. and Cryan, J.F., 2011. Maternal separation as a model of brain-gut axis dysfunction. Psychopharmacology 214: 71-88.
'Maternal separation as a model of brain-gut axis dysfunction ' () 214 Psychopharmacology : 71 -88.
-
O'Mahony, S.M., Marchesi, J.R., Scully, P., Codling, C., Ceolho, A.M., Quigley, E.M., Cryan, J.F. and Dinan, T.G., 2009. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biological Psychiatry 65: 263-267.
'Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses ' () 65 Biological Psychiatry : 263 -267.
-
Oitzl, M.S., Workel, J.O., Fluttert, M., Frosch, F. and De Kloet, E.R., 2000. Maternal deprivation affects behaviour from youth to senescence: amplification of individual differences in spatial learning and memory in senescent Brown Norway rats. European Journal of Neuroscience 12: 3771-3780.
'Maternal deprivation affects behaviour from youth to senescence: amplification of individual differences in spatial learning and memory in senescent Brown Norway rats ' () 12 European Journal of Neuroscience : 3771 -3780.
-
Pang, P.T., Teng, H.K., Zaitsev, E., Woo, N.T., Sakata, K., Zhen, S., Teng, K.K., Yung, W.H., Hempstead, B.L. and Lu, B., 2004. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306: 487-491.
'Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity ' () 306 Science : 487 -491.
-
Plotsky, P.M. and Meaney, M.J., 1993. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Molecular Brain Research 18: 195-200.
'Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats ' () 18 Molecular Brain Research : 195 -200.
-
Poo, M.-M., 2001. Neurotrophins as synaptic modulators. Nature Reviews Neuroscience 2: 24-32.
'Neurotrophins as synaptic modulators ' () 2 Nature Reviews Neuroscience : 24 -32.
-
Quigley, E.M., 2011. Therapies aimed at the gut microbiota and inflammation: antibiotics, prebiotics, probiotics, synbiotics, anti-inflammatory therapies. Gastroenterology Clinics of North America 40: 207-222.
'Therapies aimed at the gut microbiota and inflammation: antibiotics, prebiotics, probiotics, synbiotics, anti-inflammatory therapies ' () 40 Gastroenterology Clinics of North America : 207 -222.
-
Robinson, R.C., Radziejewski, C., Spraggon, G., Greenwald, J., Kostura, M.R., Burtnick, L.D., Stuart, D.I., Choe, S. and Jones, E.Y., 1999. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. Protein Science 8: 2589-2597.
'The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site ' () 8 Protein Science : 2589 -2597.
-
Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G. and Riva, M.A., 2004. Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions. Biological Psychiatry 55: 708-714.
'Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions ' () 55 Biological Psychiatry : 708 -714.
-
Russo-Neustadt, A., Ha, T., Ramirez, R. and Kesslak, J.P., 2001. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behavioural Brain Research 120: 87-95.
'Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model ' () 120 Behavioural Brain Research : 87 -95.
-
Seidah, N.G., Benjannet, S., Pareek, S., Savaria, D., Hamelin, J., Goulet, B., Laliberte, J., Lazure, C., Chretien, M. and Murphy, R.A., 1996. Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Biochemical Journal 314: 951-960.
'Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases ' () 314 Biochemical Journal : 951 -960.
-
Shanahan, F., 1999. Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology. Seminars in Gastrointestinal Disease 10: 8-13.
'Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology ' () 10 Seminars in Gastrointestinal Disease : 8 -13.
-
Smith, M.A., Makino, S., Kim, S.Y. and Kvetnansky, R., 1995. Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology 136: 3743-3750.
'Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary ' () 136 Endocrinology : 3743 -3750.
-
Smith, M.E., 2005. Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus 15: 798-807.
'Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies ' () 15 Hippocampus : 798 -807.
-
Spiller, R., 2008. Probiotics and prebiotics in irritable bowel syndrome. Alimentary Pharmacology and Therapeutics 28: 385-396.
'Probiotics and prebiotics in irritable bowel syndrome ' () 28 Alimentary Pharmacology and Therapeutics : 385 -396.
-
Tache, Y. and Bonaz, B., 2007. Corticotropin-releasing factor receptors and stress-related alterations of gut motor function. The Journal of Clinical Investigation 117: 33-40.
'Corticotropin-releasing factor receptors and stress-related alterations of gut motor function ' () 117 The Journal of Clinical Investigation : 33 -40.
-
Teng, H.K., Teng, K.K., Lee, R., Wright, S., Tevar, S., Almeida, R.D., Kermani, P., Torkin, R., Chen, Z.Y., Lee, F.S., Kraemer, R.T., Nykjaer, A. and Hempstead, B.L., 2005. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of Neuroscience 25: 5455-5463.
'ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin ' () 25 The Journal of Neuroscience : 5455 -5463.
-
Thoenen, H., 1995. Neurotrophins and neuronal plasticity. Science 270: 593-598.
'Neurotrophins and neuronal plasticity ' () 270 Science : 593 -598.
-
Thome, J., Foley, P. and Riederer, P., 1998. Neurotrophic factors and the maldevelopmental hypothesis of schizophrenic psychoses. Journal of Neural Transmission 105: 85-100.
'Neurotrophic factors and the maldevelopmental hypothesis of schizophrenic psychoses ' () 105 Journal of Neural Transmission : 85 -100.
-
Tsankova, N.M., Berton, O., Renthal, W., Kumar, A., Neve, R.L. and Nestler, E.J., 2006. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature Neuroscience 9: 519-525.
'Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action ' () 9 Nature Neuroscience : 519 -525.
-
Tyler, W.J., Alonso, M., Bramham, C.R. and Pozzo-Miller, L.D., 2002. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learning and Memory 9: 224-237.
'From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning ' () 9 Learning and Memory : 224 -237.
-
Van Oers, H.J., De Kloet, E.R., Li, C. and Levine, S., 1998. The ontogeny of glucocorticoid negative feedback: influence of maternal deprivation. Endocrinology 139: 2838-2846.
'The ontogeny of glucocorticoid negative feedback: influence of maternal deprivation ' () 139 Endocrinology : 2838 -2846.
-
Verdu, E.F., Bercik, P., Bergonzelli, G.E., Huang, X.X., Blennerhasset, P., Rochat, F., Fiaux, M., Mansourian, R., Corthesy-Theulaz, I. and Collins, S.M., 2004. Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction. Gastroenterology 127: 826-837.
-
Vyas, A., Mitra, R., Shankaranarayana Rao, B.S. and Chattarji, S., 2002. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. The Journal of Neuroscience 22: 6810-6818.
'Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons ' () 22 The Journal of Neuroscience : 6810 -6818.
-
Wakefield, A.J., 2002. The gut-brain axis in childhood developmental disorders. Journal of Pediatric Gastroenterology and Nutrition 34 Suppl. 1: S14-S17.
-
Weickert, C.S., Hyde, T.M., Lipska, B.K., Herman, M.M., Weinberger, D.R. and Kleinman, J.E., 2003. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Molecular Psychiatry 8: 592-610.
'Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia ' () 8 Molecular Psychiatry : 592 -610.
-
Wigger, A. and Neumann, I.D., 1999. Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats. Physiology and Behavior 66: 293-302.
'Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats ' () 66 Physiology and Behavior : 293 -302.
-
Woo, N.H., Teng, H.K., Siao, C.J., Chiaruttini, C., Pang, P.T., Milner, T.A., Hempstead, B.L. and Lu, B., 2005. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience 8: 1069-1077.
'Activation of p75NTR by proBDNF facilitates hippocampal long-term depression ' () 8 Nature Neuroscience : 1069 -1077.
-
Workel, J.O., Oitzl, M.S., Fluttert, M., Lesscher, H., Karssen, A. and De Kloet, E.R., 2001. Differential and age-dependent effects of maternal deprivation on the hypothalamic-pituitary-adrenal axis of brown norway rats from youth to senescence. Journal of Neuroendocrinology 13: 569-580.
'Differential and age-dependent effects of maternal deprivation on the hypothalamic-pituitary-adrenal axis of brown norway rats from youth to senescence ' () 13 Journal of Neuroendocrinology : 569 -580.
-
Yamada, K., Mizuno, M. and Nabeshima, T., 2002. Role for brain-derived neurotrophic factor in learning and memory. Life Sciences 70: 735-744.
'Role for brain-derived neurotrophic factor in learning and memory ' () 70 Life Sciences : 735 -744.
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BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?
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2Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
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2Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
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5Department of Medicine, University College Cork, Clinical Sciences Building, Cork, Ireland
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3Department of Anatomy, University College Cork, Windle Building, Cork, Ireland
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4Department of Psychiatry, University College Cork, Cork University Hospital, Cork, Ireland
t.dinan@ucc.ie
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Abstract
Brain-derived neurotrophic factor (BDNF) is of interest because of its putative role in stress and psychiatric disorders. Maternal separation is used as an animal model of early-life stress and of irritable bowel syndrome (IBS). Animals exposed to the paradigm show altered gut function together with heightened levels of arousal and corticosterone. Some probiotic organisms have been shown to be of benefit in IBS and influence the brain-gut axis. Our objective was to investigate the effects of maternal separation on BDNF under basal conditions and in response to the probiotic Bifidobacterium breve 6330. The study implemented the maternal separation model which we have previously described. Polymerase chain reaction and in situ hybridisation were performed to measure the effect of maternal separation on both BDNF total variants and BDNF splice variant (exon) IV in the hippocampus. Maternally separated and non-separated rats were treated with B. breve 6330, to investigate the effect of this probiotic on BDNF total variant and BDNF exon IV expression. Maternal separation increased BDNF total variants (P<0.01), whilst having no effect on BDNF exon IV. B. breve 6330 increased BDNF total variants (P<0.01), and decreased BDNF splice variant IV, in non-separated rats (P<0.01). B. breve 6330 did not alter BDNF levels in the maternally separated rats. Maternal separation caused a marked increase in BDNF in the hippocampus. While B. breve 6330 influenced BDNF in normal animals, it had no significant effect on BDNF in those which were maternally separated. We have demonstrated that an orally administered probiotic can influence hippocampal BDNF.
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