Save

The metabolic responses of HepG2 cells to the exposure of mycotoxin deoxynivalenol

In: World Mycotoxin Journal
Authors:
Y. Liu School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.

Search for other papers by Y. Liu in
Current site
Google Scholar
PubMed
Close
,
R. Ran School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.
Faculty of Agricultural and Environmental Sciences, McGill University, H9X 3V9 Montreal, Canada.

Search for other papers by R. Ran in
Current site
Google Scholar
PubMed
Close
,
C. Hu School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.

Search for other papers by C. Hu in
Current site
Google Scholar
PubMed
Close
,
B. Cui School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.
Shanghai Hengrui Pharmaceutical Co. Ltd, Shanghai 200245, China P.R.

Search for other papers by B. Cui in
Current site
Google Scholar
PubMed
Close
,
Y. Xu School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.
College of Education, Shanghai Normal University, Shanghai 201418, China P.R.

Search for other papers by Y. Xu in
Current site
Google Scholar
PubMed
Close
,
H. Liu School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.

Search for other papers by H. Liu in
Current site
Google Scholar
PubMed
Close
,
S. Quan School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.

Search for other papers by S. Quan in
Current site
Google Scholar
PubMed
Close
,
D. Li School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China P.R.

Search for other papers by D. Li in
Current site
Google Scholar
PubMed
Close
,
X. Li Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China P.R.

Search for other papers by X. Li in
Current site
Google Scholar
PubMed
Close
,
Y. Wu Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China P.R.

Search for other papers by Y. Wu in
Current site
Google Scholar
PubMed
Close
,
D. Zhang School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.
Plant Genomics Center, School of Agriculture, Food and Wine, University of Adelaide, Waite Campus, Urrbrae 5064, Australia.

Search for other papers by D. Zhang in
Current site
Google Scholar
PubMed
Close
, and
J. Shi School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – University of Adelaide Joint Centre for Agriculture and Health, Shanghai Jiao Tong University, Shanghai 200240, China P.R.

Search for other papers by J. Shi in
Current site
Google Scholar
PubMed
Close
Download Citation Get Permissions

Access options

Get access to the full article by using one of the access options below.

Institutional Login

Log in with Open Athens, Shibboleth, or your institutional credentials

Login via Institution

Purchase

Buy instant access (PDF download and unlimited online access):

€36.93

As the number of reported deoxynivalenol (DON) contamination incidents increased steadily over the past decades, there has been a widespread interest in understanding the cellular mechanisms of the toxicological effects of DON usingin vitro systems and omics technologies. The present investigation was conducted to understand the metabolomic changes in human hepatocellular carcinoma cells (HepG2) exposed to 10 μM DON for short term (4 h) and long term (12 h) periods, using a non-targeted metabolomics approach. Our results revealed a remarkable metabolic shift from short term to long term exposure to DON in HepG2 cells. Our metabolomics data also confirmed the role of DON induced oxidative stress in DON toxicity. Coupled with pattern recognition and pathway analysis, effects of DON on redox homeostasis, energy balance, lipid metabolism, and potential toxicological mechanisms were discussed, which would facilitate further studies on the risk assessment of the dietary mycotoxin DON.

Content Metrics

All Time Past 365 days Past 30 Days
Abstract Views 459 128 21
Full Text Views 29 2 0
PDF Views & Downloads 5 0 0