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First report of mycophenolic acid production byEurotium repens isolated from agricultural and indoor environments

In: World Mycotoxin Journal
Authors:
V. Séguin ABTE EA 4651, Equipe ToxEMAC, Université de Caen Basse-Normandie and Centre François Baclesse, Avenue du Général Harris, 14076 Caen Cedex 05, France

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S. Gente ABTE EA 4651, Equipe ToxEMAC, Université de Caen Basse-Normandie and Centre François Baclesse, Avenue du Général Harris, 14076 Caen Cedex 05, France

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N. Heutte INSERM U1086, Université de Caen Basse-Normandie and Centre François Baclesse, Avenue du Général Harris, 14076 Caen Cedex 05, France

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P. Vérité ABTE EA 4651, Equipe ToxEMAC, Université de Rouen, UFR de Médecine-Pharmacie, Boulevard Gambetta, 76000 Rouen, France

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V. Kientz-Bouchart Laboratoire Frank Duncombe, Conseil Général du Calvados, 14053 Caen Cedex 04, France

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L. Sage LECA UMR 5553, Université Joseph Fourier, BP 53, Rue de la Piscine, 38041 Grenoble Cedex 9, France

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D. Goux Centre de Microscopie Appliquée à la Biologie, Université de Caen Basse-Normandie, , Esplanade de la Paix, 14032 Caen Cedex, France

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D. Garon ABTE EA 4651, Equipe ToxEMAC, Université de Caen Basse-Normandie and Centre François Baclesse, Avenue du Général Harris, 14076 Caen Cedex 05, France

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Mycophenolic acid is considered as an immunosuppressive pharmaceutical drug, but also as a mycotoxin due to its undesirable presence in various feedstuffs. AlthoughPenicillium brevicompactum has been historically identified as the major producer of mycophenolic acid, this study reports for the first time the production of mycophenolic acid by isolates ofEurotium repens collected from agricultural and indoor environments. Fungal identification was achieved by scanning electron microscopy and molecular techniques, and mycophenolic acid production was confirmed by two analytical methods (gas and liquid chromatography coupled to mass spectrometry). These findings suggest that mycophenolic acid production and immunosuppressive properties of other closely relatedEurotium should be evaluated in future studies.

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