Association between aflatoxin M1 exposure through breast milk and growth impairment in infants from Northern Tanzania
äºWorld Mycotoxin JournalSearch for other papers by H. Magoha in
Current site
Google Scholar
Search for other papers by M. Kimanya in
Current site
Google Scholar
Search for other papers by B. De Meulenaer in
Current site
Google Scholar
Search for other papers by D. Roberfroid in
Current site
Google Scholar
Search for other papers by C. Lachat in
Current site
Google Scholar
Search for other papers by P. Kolsteren in
Current site
Google Scholar
Infants breastfeeding from mothers consuming aflatoxin contaminated foods may be exposed to aflatoxin M1 (AFM1), a metabolite of aflatoxin B1. This study estimated the association between AFM1 exposure levels and growth indicators, for infants under six months of age in the Rombo district in Northern Tanzania. A total of 143 infants and their mothers were involved. Breast-milk samples, infants' anthropometric data and 24 h dietary recall for mothers were taken at the 1st, 3rd and 5th months of children age. AFM1 contaminations in the samples were determined using HPLC. Aflatoxin M1 exposure by an infant was estimated by multiplying contamination in the breast milk consumed by him/her with the breast milk intake recorded by the United States Environmental Protection Agency for infants of his/her age divided by the infant's body weight. All the breast-milk samples were contaminated by AFM1 at levels ranging from 0.01 to 0.55 ng/ml. Above 90% of samples exceeded the EU limit of 0.025 ng/ml for infants' foods while over 76% exceeded the EU limit of 0.05 ng/ml for dairy milk and milk products. Only 1% of the samples exceeded the limit of 0.5 ng/ml set for dairy milk in the United States and several countries in Asia. AFM1 Exposures ranged from 1.13-66.79 ng/kg body weight per day. A small but significant (P<0.05) inverse association was observed between AFM1 exposure levels and weight for age Z-score or height for age Z-score. Appropriate strategies should be applied to minimise aflatoxin B1 exposure in lactating mothers in order to protect infants from AFM1 exposure.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Alonso, V.A., Monge, M.P., Larriestra, A., Dalcero A.M., Cavaglieriae, L.R. and Chiacchiera S.M., 2010. Naturally occurring aflatoxin M1 in raw bulk milk from farm cooling tanks in Argentina. Food Additives and Contaminants Part A 27: 373-379.
'Naturally occurring aflatoxin M1 in raw bulk milk from farm cooling tanks in Argentina ' () 27 Food Additives and Contaminants Part A : 373 -379.
-
Black, R.E., Allen, L.H., Bhutta, Z.A., Caulfield, L.E., De Onis, M., Ezzati, M., Mathers, C. and Rivera, J., 2008. Maternal and child undernutrition: global and regional exposures and health consequences. The Lancet 371: 243-260.
'Maternal and child undernutrition: global and regional exposures and health consequences ' () 371 The Lancet : 243 -260.
-
Clewell, R.A. and Gearhart, J.M., 2002. Pharmacokinetics of toxic chemicals in breast milk: use of PBPK models to predict infant exposure. Environmental Health Perspectives 110: 333-337.
'Pharmacokinetics of toxic chemicals in breast milk: use of PBPK models to predict infant exposure ' () 110 Environmental Health Perspectives : 333 -337.
-
El-Tras, W.F., El-Kady, N.N. and Tayel, A.A., 2011. Infants exposure to aflatoxin M1 as a novel foodborne zoonosis. Food and Chemical Toxicology 49: 2816-2819.
'Infants exposure to aflatoxin M1 as a novel foodborne zoonosis ' () 49 Food and Chemical Toxicology : 2816 -2819.
-
European-Commission (EC), 2006. Commission Regulation (EC) no. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Official Journal of the European Union L 364: 5-24.
-
Food and Agriculture Organization (FAO), 2004. Worldwide regulations for mycotoxins in food and feed in 2003. FAO Food and Nutrition Paper 81, Rome, Italy.
-
Galvano, F., Pietri, A., Bertuzzi, T., Gagliardi, L., Ciotti, S., Luisi, S., Bognanno, M., La Fauci, L., Lacopino, A., Nigro, F., Li Volti, G., Vanella, L., Giammanco, G., Tina, G. and Gazzolo, D., 2008. Maternal dietary habits and mycotoxin occurrence in human mature milk. Molecular Nutrition and Food Research 52: 496-501.
'Maternal dietary habits and mycotoxin occurrence in human mature milk ' () 52 Molecular Nutrition and Food Research : 496 -501.
-
Ghiasain, S.A., 2012. Infantsâ exposure to aflatoxin M1 from mother's breast milk in Iran. Iranian Journal of Public Health 41: 119-126.
'Infantsâ exposure to aflatoxin M1 from mother's breast milk in Iran ' () 41 Iranian Journal of Public Health : 119 -126.
-
Gong, Y.Y., Egal S., Hounsa, A., Turner, P.C., Hall, A.J., Cardwell, K.F. and Wild, C.P., 2003. Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning. International Journal of Epidemiology 32: 556-562.
'Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning ' () 32 International Journal of Epidemiology : 556 -562.
-
Gong, Y., Hounsa, A., Egal, S., Turner, P.C., Sutcliffe, A.E., Hall, A.J., Cardwell, K. and Wild, C.P., 2004. Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environmental Health Perspectives 112: 1334-1338.
'Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa ' () 112 Environmental Health Perspectives : 1334 -1338.
-
Gurbay, A., Sabuncuoglu, S., Girgin, G., Sahin, G., Yigit, S., Yurdakok, M. and Tekinalp, G., 2010. Exposure of newborns to aflatoxin M1 and B1 from mothersâ breast milk in Ankara, Turkey. Food and Chemical Toxicology 48: 314-319.
'Exposure of newborns to aflatoxin M1 and B1 from mothersâ breast milk in Ankara, Turkey ' () 48 Food and Chemical Toxicology : 314 -319.
-
Hoddinott, J. and Yohannes, Y., 2002. Dietary diversity as a household food security indicator. Food and Nutrition Technical Assistance Project, Academy for Educational Development, Washington, DC, USA.
-
International Agency for Research on Cancer (IARC), 2002. Aflatoxins. In: Monographs on the evaluation of carcinogenic risks to humans. Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, volume 82. IARC, Lyon, France, pp. 171-274.
-
Jimenez, M., Huerta, T. and Mateo, R., 1997. Mycotoxin production byFusarium species isolated from bananas. Applied Environmental Microbiology 63: 364-369.
'Mycotoxin production by Fusarium species isolated from bananas ' () 63 Applied Environmental Microbiology : 364 -369.
-
Kimanya, M.E., De Meulenaer, B., Baert, K., Tiisekwa, B., Van Camp, J., Samapundo, S., Lachat, C. and Kolsteren, P., 2009. Exposure of infants to fumonisins in maize based complementary foods in rural Tanzania. Molecular Nutrition and Food Research 53: 667-674.
'Exposure of infants to fumonisins in maize based complementary foods in rural Tanzania ' () 53 Molecular Nutrition and Food Research : 667 -674.
-
Kimanya, M.E., De Meulenaer, B., Tiisekwa, B., Ndomondo-Sigonda, M., Devlieghere, F., Van Camp, J. and Kolsteren, P., 2008. Co-occurrence of fumonisins with aflatoxins in home-stored maize for human consumption in rural villages of Tanzania. Food Additives and Contaminants Part A 25: 1353-1364.
'Co-occurrence of fumonisins with aflatoxins in home-stored maize for human consumption in rural villages of Tanzania ' () 25 Food Additives and Contaminants Part A : 1353 -1364.
-
Lamplugh, S., Hendrickse, R., Apeagyei, F. and Mwanmut, D., 1988. Aflatoxins in breast milk, neonatal cord blood, and serum of pregnant women. British Medical Journal 296: 968.
'Aflatoxins in breast milk, neonatal cord blood, and serum of pregnant women ' () 296 British Medical Journal : 968.
-
Lee, J.E., Kwak, B., Ahn, J. and Jeon, T., 2009. Occurrence of aflatoxin M1 in raw milk in South Korea using an immunoaffinity column and liquid chromatography. Food Control 20: 136-138.
'Occurrence of aflatoxin M1 in raw milk in South Korea using an immunoaffinity column and liquid chromatography ' () 20 Food Control : 136 -138.
-
Lin, L., Liu, F., Fu, Y. and Shih, D., 2004. Survey of aflatoxin M1 contamination of dairy products in Taiwan. Journal of Food and Drug Analysis 12: 154-160.
'Survey of aflatoxin M1 contamination of dairy products in Taiwan ' () 12 Journal of Food and Drug Analysis : 154 -160.
-
Mamiro, P.S., Kolsteren, P., Roberfroid, D., Tatala, S., Opsomer, A.S. and Van Camp, J.H., 2005. Feeding practices and factors contributing to wasting, stunting, and iron-deficiency anaemia among 3-23-month old children in Kilosa district, rural Tanzania. Journal of Health, Population and Nutrition 23: 222-230.
'Feeding practices and factors contributing to wasting, stunting, and iron-deficiency anaemia among 3-23-month old children in Kilosa district, rural Tanzania ' () 23 Journal of Health, Population and Nutrition : 222 -230.
-
Manjula, K., Hell, K., Fandohan, P., Abass, A. and Bandyopadhyay, R., 2009. Aflatoxin and fumonisin contamination of cassava products and maize grain from markets in Tanzania and republic of the Congo. Toxin Reviews 28: 63-69.
'Aflatoxin and fumonisin contamination of cassava products and maize grain from markets in Tanzania and republic of the Congo ' () 28 Toxin Reviews : 63 -69.
-
Marin, D.E., Taranu, I., Bunaciu, R.P., Pascale, F., Tudor, D.S., Avram, N., Sarca, M., Cureu, I., Criste, R.D., Suta, V. and Oswald, I.P., 2002 Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin. Journal of Animal Science 80: 1250-1257.
'Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin ' () 80 Journal of Animal Science : 1250 -1257.
-
Mboya, R., Tongoona, P., Yobo, K.S., Derera, J., Mudhara, M. and Langyintuo A., 2011. The quality of maize stored using roof and sack storage methods in Katumba Ward, Rungwe District, Tanzania: implications on household food security. Journal of Stored Products and Postharvest Research 2: 189-199.
'The quality of maize stored using roof and sack storage methods in Katumba Ward, Rungwe District, Tanzania: implications on household food security ' () 2 Journal of Stored Products and Postharvest Research : 189 -199.
-
Navas, S., Sabino M. and Rodriguez-Amaya, D., 2005. Aflatoxin M1 and ochratoxin A in a human milk bank in the city of São Paulo, Brazil. Food Additives and Contaminants 22: 457-462.
'Aflatoxin M1 and ochratoxin A in a human milk bank in the city of São Paulo, Brazil ' () 22 Food Additives and Contaminants : 457 -462.
-
Nyaruhucha, C.N., Msuya, J.M., Mamiro, P.S. and Kerengi, A.J., 2006. Nutritional status and feeding practices of under-five children in Simanjiro District, Tanzania. Tanzania Health Research Bulletin 8: 162-167.
'Nutritional status and feeding practices of under-five children in Simanjiro District, Tanzania ' () 8 Tanzania Health Research Bulletin : 162 -167.
-
Oveisi, M., Jannat, B., Sadeghi, N., Hajimahmoodi, M. and Nikzad, A., 2007. Presence of aflatoxin M1 in milk and infant milk products in Tehran, Iran. Food Control 18: 1216-1218.
'Presence of aflatoxin M1 in milk and infant milk products in Tehran, Iran ' () 18 Food Control : 1216 -1218.
-
Polychronaki, N., 2007. Biomarkers of aflatoxin exposure and a dietary intervention. studies in infants and children from Egypt and Guinea and young adults from China. Kuopio University Publications D Medical Sciences 408. Available at: http://epublications.uef.fi/pub/urn_isbn_978-951-27-0745-4.http://epublications.uef.fi/pub/urn_isbn_978-951-27-0745-4
-
Polychronaki N., Turner, P.C., Mykkänen, H., Gong, Y., Amra, H., Abdel-Wahhab, M. and El-Nezami, H., 2006. Determinants of aflatoxin1 in breast milk in a selected group of Egyptian mothers. Food Additives and Contaminants 23: 700-708.
'Determinants of aflatoxin M1 in breast milk in a selected group of Egyptian mothers. ' () 23 od Additives and Contaminants : 700 -708.
-
Prandini, A., Tansini, G., Sigolo, S., Filippi, L., Laporta, M. and Piva, G., 2009. Review on the occurrence of aflatoxin M1 in milk and dairy products. Food and Chemical Toxicology 47: 984-991.
'Review on the occurrence of aflatoxin M1 in milk and dairy products ' () 47 Food and Chemical Toxicology : 984- -91.
-
Rabe-Hesketh, S. and Skrondal, A., 2012. Multilevel and longitudinal modeling using Stata, 3rd Edition. Stata Press, College Station, TX, USA.
Multilevel and longitudinal modeling using Stata , ().
-
Reddy, K., Salleh, B., Saad, B., Abbas, H., Abel, C. and Shier, W., 2010. An overview of mycotoxin contamination in foods and its implications for human health. Toxin Reviews 29: 3-26.
'An overview of mycotoxin contamination in foods and its implications for human health ' () 29 Toxin Reviews : 3 -26.
-
Shephard, G.S., 2008. Impact of mycotoxins on human health in developing countries. Food Additives and Contaminants Part A 25: 146-151.
'Impact of mycotoxins on human health in developing countries ' () 25 Food Additives and Contaminants Part A : 146 -151.
-
Shirima, R., Greiner, T., Kylberg, E. and Gebre-Medhin, M., 2001. Exclusive breast-feeding is rarely practised in rural and urban Morogoro, Tanzania. Public Health Nutrition 4: 147-154.
'Exclusive breast-feeding is rarely practised in rural and urban Morogoro, Tanzania ' () 4 Public Health Nutrition : 147 -154.
-
Shirima, C.P., Kimanya, M.E., Kinabo, J.L., Routledge, M.N., Srey, C., Wild, C.P. and Gong, Y.Y., 2013. Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure. Molecular Nutrition and Food Research 57: 1874-1881.
'Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure ' () 57 Molecular Nutrition and Food Research : 1874 -1881.
-
Shundo, L., Navas, S.A., Lamardo, L.A., Ruvieri, V. and Sabino M., 2009. Estimate of aflatoxin M1 exposure in milk and occurrence in Brazil. Food Control 20: 655-657.
'Estimate of aflatoxin M1 exposure in milk and occurrence in Brazil ' () 20 Food Control : 655 -657.
-
Somogyi, A. and Beck, H., 1993. Nurturing and breast-feeding: exposure to chemicals in breast milk. Environmental Health Perspectives Supplements 101: 45-52.
'Nurturing and breast-feeding: exposure to chemicals in breast milk ' () 101 Environmental Health Perspectives Supplements : 45 -52.
-
Turner, P.C., 2013. The molecular epidemiology of chronic aflatoxin driven impaired child growth. Scientifica 2013: 152879.
'The molecular epidemiology of chronic aflatoxin driven impaired child growth ' () 2013 Scientifica : 152879.
-
Turner, P.C., Collinson, A.C., Cheung, Y.B., Gong, Y.Y., Hall, A.J., Prentice, A.M. and Wild, C.P., 2007. Aflatoxin exposure in utero causes growth faltering in Gambian infants. International Journal of Epidemiology 36: 1119-1125.
'Aflatoxin exposure in utero causes growth faltering in Gambian infants ' () 36 International Journal of Epidemiology : 1119 -1125.
-
United States Environmental Protection Agency (US-EPA), 2011. Exposure factors handbook: 2011 edition. National Center for Environmental Assessment, Washington, DC, USA. Available at: http://www.epa.gov/ncea/efh.http://www.epa.gov/ncea/efh
-
Wagacha, J.M. and Muthomi, J.W., 2008 Mycotoxin problem in Africa: current status, implications to food safety and health and possible management strategies. International Journal of Food Microbiology 124: 1-12.
'Mycotoxin problem in Africa: current status, implications to food safety and health and possible management strategies ' () 124 International Journal of Food Microbiology : 1 -12.
-
Williams, J.H., Phillips, T.D., Jolly, P.E., Stiles, J.K., Jolly, C.M. and Aggarwal, D., 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. American Journal of Clinical Nutrition 80: 1106-1122.
'Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions ' () 80 American Journal of Clinical Nutrition : 1106 -1122.
-
World Health Organization (WHO), 2006. Child growth standards based on length/height, weight and age. Acta Paediatric Supplement 450: 76-85.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 454 | 194 | 8 |
| å ¨ææµè§æ¬¡æ° | 68 | 2 | 0 |
| PDFä¸è½½æ¬¡æ° | 48 | 3 | 0 |
Association between aflatoxin M1 exposure through breast milk and growth impairment in infants from Northern Tanzania
äºWorld Mycotoxin JournalSearch for other papers by H. Magoha in
Current site
Google Scholar
PubMed
Search for other papers by M. Kimanya in
Current site
Google Scholar
PubMed
Search for other papers by B. De Meulenaer in
Current site
Google Scholar
PubMed
Search for other papers by D. Roberfroid in
Current site
Google Scholar
PubMed
Search for other papers by C. Lachat in
Current site
Google Scholar
PubMed
Search for other papers by P. Kolsteren in
Current site
Google Scholar
PubMed
Infants breastfeeding from mothers consuming aflatoxin contaminated foods may be exposed to aflatoxin M1 (AFM1), a metabolite of aflatoxin B1. This study estimated the association between AFM1 exposure levels and growth indicators, for infants under six months of age in the Rombo district in Northern Tanzania. A total of 143 infants and their mothers were involved. Breast-milk samples, infants' anthropometric data and 24 h dietary recall for mothers were taken at the 1st, 3rd and 5th months of children age. AFM1 contaminations in the samples were determined using HPLC. Aflatoxin M1 exposure by an infant was estimated by multiplying contamination in the breast milk consumed by him/her with the breast milk intake recorded by the United States Environmental Protection Agency for infants of his/her age divided by the infant's body weight. All the breast-milk samples were contaminated by AFM1 at levels ranging from 0.01 to 0.55 ng/ml. Above 90% of samples exceeded the EU limit of 0.025 ng/ml for infants' foods while over 76% exceeded the EU limit of 0.05 ng/ml for dairy milk and milk products. Only 1% of the samples exceeded the limit of 0.5 ng/ml set for dairy milk in the United States and several countries in Asia. AFM1 Exposures ranged from 1.13-66.79 ng/kg body weight per day. A small but significant (P<0.05) inverse association was observed between AFM1 exposure levels and weight for age Z-score or height for age Z-score. Appropriate strategies should be applied to minimise aflatoxin B1 exposure in lactating mothers in order to protect infants from AFM1 exposure.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 454 | 194 | 8 |
| å ¨ææµè§æ¬¡æ° | 68 | 2 | 0 |
| PDFä¸è½½æ¬¡æ° | 48 | 3 | 0 |
