Determination of nivalenol in food and feed: an update
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Based on the recent scientific opinion published by the EFSA CONTAM panel on the risks to human and animal health related to the presence of nivalenol in food and feed, this article provides an update on the determination of thisFusarium mycotoxin. After a brief introduction into the chemistry of nivalenol, chromatographic methods as well as other approaches are being discussed. Methods for the determination of nivalenol are well established and can be applied for the analysis of cereals, food, feed and biological samples. Accurate quantification of nivalenol is mostly carried out by liquid chromatography coupled with (multi-stage) mass spectrometry (MS) often within a multi-analyte approach. Some novel techniques, such as direct analysis in real time (DART) MS and electrochemical methods, have shown potential to determine nivalenol, but applications for routine measurements are not yet available. None of the currently available analytical methods has been formally validated in interlaboratory validation studies. While a certified calibrant for nivalenol is available, no matrix reference materials have been developed. Due to the scarcity of appropriate antibodies also no rapid immunochemical methods specific for nivalenol have become available.
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Determination of nivalenol in food and feed: an update
In: World Mycotoxin JournalSearch for other papers by A. Malachova in
Current site
Google Scholar
PubMed
Search for other papers by H.P. van Egmond in
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PubMed
Search for other papers by F. Berthiller in
Current site
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PubMed
Search for other papers by R. Krska in
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Based on the recent scientific opinion published by the EFSA CONTAM panel on the risks to human and animal health related to the presence of nivalenol in food and feed, this article provides an update on the determination of thisFusarium mycotoxin. After a brief introduction into the chemistry of nivalenol, chromatographic methods as well as other approaches are being discussed. Methods for the determination of nivalenol are well established and can be applied for the analysis of cereals, food, feed and biological samples. Accurate quantification of nivalenol is mostly carried out by liquid chromatography coupled with (multi-stage) mass spectrometry (MS) often within a multi-analyte approach. Some novel techniques, such as direct analysis in real time (DART) MS and electrochemical methods, have shown potential to determine nivalenol, but applications for routine measurements are not yet available. None of the currently available analytical methods has been formally validated in interlaboratory validation studies. While a certified calibrant for nivalenol is available, no matrix reference materials have been developed. Due to the scarcity of appropriate antibodies also no rapid immunochemical methods specific for nivalenol have become available.
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