The current state of mycotoxin biomarker development in humans and animals and the potential for application to plant systems
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Filamentous fungi that contaminate livestock feeds and human food supply often produce toxigenic secondary metabolites known as mycotoxins. Among the hundreds of known mycotoxins, aflatoxins, deoxynivalenol, fumonisins, ochratoxin A and zearalenone are considered the most commercially important. Intense research on these mycotoxins, especially aflatoxin, has resulted in the development of 'biomarkers' used to link exposure to disease risk. In the case of aflatoxin this effort has led to the discovery of both exposure and mechanism-based biomarkers, which have proven essential for understanding aflatoxin's potential for causing disease in humans, including subtle effects on growth and immune response. Fumonisin biomarkers have also been used extensively in farm and laboratory animals to study the fumonisin-induced disruption of cellular and systemic physiology which leads to disease. This review summarises the status of mycotoxin biomarker development in humans and animals for the commercially important mycotoxins. Since the fungi responsible for the production of these mycotoxins are often endophytes that infect and colonise living plant tissues, accumulation of mycotoxins in the plant tissues may at times be associated with development of plant disease symptoms. The presence of mycotoxins, even in the absence of disease symptoms, may still have subtle biological effects on the physiology of plants. This review examines the question of whether or not the knowledge gained from mechanistic studies and development of biomarkers in animal and human systems is transferable to the study of mycotoxin effects on plant systems. Thus far, fumonisin has proven amenable to development of mechanism-based biomarkers to study maize seedling disease caused by the fumonisin producer, Fusarium verticillioides. Expanding our knowledge of mechanisms of toxicity and the overt and subtle effects on animal, human, and plant systems through the identification and validation of biomarkers will further our ability to monitor and limit the damage and economic impact of mycotoxins.
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-
Abbas, H., Tanaka, T., Duke, S., Porter, J., Wray, E., Hodges, L., Sessions, A., Wang, E., Merrill Jr., A. and Riley, R., 1994. Fumonisin-and AAL-toxin-induced disruption of sphingolipid metabolism with accumulation of free sphingoid bases. Plant Physiology 106: 1085-1093.
'Fumonisin-and AAL-toxin-induced disruption of sphingolipid metabolism with accumulation of free sphingoid bases ' () 106 Plant Physiology : 1085 -1093 .
-
Atkinson, A.J., Colburn, W.A., DeGruttola, V.G., DeMets, D.L., Downing, G.J., Hoth, D.F., Oates, J.A., Peck, C.C., Schooley, R.T., Spilker, B.A., Woodcock, J. and Zeger, S.L., 2001. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clinical Pharmacology and Therapeutics 69: 89-95.
'Biomarkers and surrogate endpoints: preferred definitions and conceptual framework ' () 69 Clinical Pharmacology and Therapeutics : 89 -95 .
-
Bacon, C.W. and Hinton, D.M., 1996. Symptomless endophytic colonization of maize by Fusarium moniliforme. Canadian Journal of Botany 74: 1195-1202.
-
Bai, G.H., Desjardins, A.E. and Plattner, R.D., 2002. Deoxynivalenol-nonproducing Fusarium graminearum causes initial infection, but does not cause disease spread in wheat spikes. Mycopathologia 153: 91-98.
'Deoxynivalenol-nonproducing Fusarium graminearum causes initial infection, but does not cause disease spread in wheat spikes ' () 153 Mycopathologia : 91 -98 .
-
Baudrimont, I., Betbeder, A.M., Gharbi, A., Pfohl-Leszkowicz, A., Dirheimer, G. and Creppy, E.E., 1994. Effect of superoxide-dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats. Toxicology 89: 101-111.
'Effect of superoxide-dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats ' () 89 Toxicology : 101 -111 .
-
Biesaga-KoÅcielniak, J. and Filek, M., 2010. Occurrence and physiology of zearalenone as a new plant hormone. Sustainable Agriculture Reviews 3: 419-435.
'Occurrence and physiology of zearalenone as a new plant hormone ' () 3 Sustainable Agriculture Reviews : 419 -435 .
-
Biesaga-KoÅcielniak, J., KoÅcielniak, J. and Janeczko, A., 2010. The impact of zearalenone and thidiazuron on indirect plant regeneration of oilseed rape and wheat. Acta Physiologiae Plantarum 32: 1047-1053.
'The impact of zearalenone and thidiazuron on indirect plant regeneration of oilseed rape and wheat ' () 32 Acta Physiologiae Plantarum : 1047 -1053 .
-
Bindschedler, L.V., Dewdney, J., Blee, K.A., Stone, J.M., Asai, T., Plotnikov, J., Denoux, C., Hayes, T., Gerrish, C., Davies, D.R., Ausubel, F.M. and Bolwell, G.P., 2006. Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance. The Plant Journal 47:851-863.
-
Boddu, J., Cho, S.H. and Muehlbauer, G.J., 2007. Transcriptome analysis of trichothecene-induced gene expression in barley. Molecular Plant-Microbe Interactions 20: 1364-1375.
'Transcriptome analysis of trichothecene-induced gene expression in barley ' () 20 Molecular Plant-Microbe Interactions : 1364 -1375 .
-
Brandwagt, B.F., Mesbah, L.A., Takken, F.L., Laurent, P.L., Kneppers, T.J., Hille, J. and Nijkamp, H.J., 2000. A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Proceedings of the National Academy of Sciences of the USA 97: 4961-4966.
-
Bush, B.J., Carson, M.L., Cubeta, M.A., Hagler, W.M. and Payne, G.A., 2004. Infection and fumonisin production by Fusarium verticillioides in developing maize kernels. Phytopathology 94: 88-93.
'Infection and fumonisin production by Fusarium verticillioides in developing maize kernels ' () 94 Phytopathology : 88 -93 .
-
CAST (Council for Agricultural Science and Technology), 2003. Mycotoxins: risks in plant and animal systems. Task Force Report No. 139, Ames, IA, USA, 199 pp.
-
Chivasa, S., Ndimba, B.K., Simon, W.J., Lindsey, K. and Slabas, A.R., 2005. Extracellular ATP functions as an endogenous external metabolite regulating plant cell viability. The Plant Cell 17: 3019-3034.
'Extracellular ATP functions as an endogenous external metabolite regulating plant cell viability ' () 17 The Plant Cell : 3019 -3034 .
-
Chohan, J.S. and Gupta, V.K., 1968. Aflaroot: a new disease of groundnut caused by Aspergillus flavus Link. Indian Journal of Agricultural Sciences 38: 568-570.
'Aflaroot: a new disease of groundnut caused by Aspergillus flavus Link ' () 38 Indian Journal of Agricultural Sciences : 568 -570 .
-
Clay, K., 2009. Defensive mutualism and grass endophytes: still valid after all these years? In: White Jr., J.F. and Torres, M.S. (eds.) Defensive mutualism in microbial symbiosis. CRC Press, Boca Raton, FL, USA, pp. 9-20.
-
Coursol, S., Fan, L.M., Le Stunff, H., Spiegel, S., Gilroy, S. and Assmann, S.M., 2003. Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. Nature 423: 651-654.
'Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins ' () 423 Nature : 651 -654 .
-
Coursol, S., Le Stunff, H., Lynch, D.V., Gilroy, S., Assmann, S.M. and Spiegel, S., 2005. Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. Plant Physiology 137: 724-737.
'Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture ' () 137 Plant Physiology : 724 -737 .
-
Desjardins, A.E. and Hohn, T.M., 1997. Mycotoxins in plant pathogenesis. Molecular Plant-Microbe Interactions 10: 147-152.
'Mycotoxins in plant pathogenesis ' () 10 Molecular Plant-Microbe Interactions : 147 -152 .
-
Desjardins, A.E., Munkvold, G.P., Plattner, R.D. and Proctor, R.H., 2002. FUM1 â a gene required for fumonisin biosynthesis but not for maize ear rot and ear infection by Gibberella moniliformis in field tests. Molecular Plant-Microbe Interactions 15: 1157-1164.
'FUM1 â a gene required for fumonisin biosynthesis but not for maize ear rot and ear infection by Gibberella moniliformis in field tests ' () 15 Molecular Plant-Microbe Interactions : 1157 -1164 .
-
Desjardins, A.E. and Plattner, R.D., 2000. Fumonisin B(1)-nonproducing strains of Fusarium verticillioides cause maize (Zea mays) ear infection and ear rot. Journal of Agricultural and Food Chemistry 48: 5773-5780.
-
Desjardins, A.E., Plattner, R.D. and Gordon, T.R., 2000. Gibberella fujikuroi mating population A and Fusarium subglutinans from teosinte species and maize from Mexico and Central America. Mycological Research 104: 865-872.
-
Desjardins, A.E., Plattner, R.D., Lu, M. and Claflin, L.E., 1998. Distribution of fumonisins in maize ears infected with strains of Fusarium moniliforme that differ in fumonisin production. Plant Disease 82: 953-958.
-
Desjardins, A.E., Plattner, R.D., Nelsen, T.C. and Leslie, J.F., 1995. Genetic analysis of fumonisin production and virulence of Gibberella fujikuroi mating population A (Fusarium moniliforme) on maize (Zea mays) seedlings. Applied and Environmental Microbiology 61: 79-86.
'Genetic analysis of fumonisin production and virulence of Gibberella fujikuroi mating population A (Fusarium moniliforme) on maize (Zea mays) seedlings ' () 61 Applied and Environmental Microbiology : 79 -86 .
-
Desjardins, A.E., Plattner, R.D., Stessman, R.J., McCormick, S.P. and Millard, M.J., 2005. Identification and heritability of fumonisin insensitivity in Zea mays. Phytochemistry 66: 2474-2480.
-
Desjardins, A.E., Proctor, R.H., Bai, G., McCormick, S.P., Shaner, G., Buechley, G. and Hohn, T.M., 1996. Reduced virulence of trichothecene-nonproducing mutants of Gibberella zeae in wheat field tests. Molecular Plant-Microbe Interactions 9: 775-781.
'Reduced virulence of trichothecene-nonproducing mutants of Gibberella zeae in wheat field tests ' () 9 Molecular Plant-Microbe Interactions : 775 -781 .
-
Desmond, O., Manners, J., Stephens, A., MacLean, D., Schenk, P., Gardiner, D., Munn, A. and Kazan, K., 2008. The Fusarium mycotoxin deoxynivalenol elicits hydrogen peroxide production, programmed cell death and defense responses in wheat. Molecular Plant Pathology 9: 435-445.
'The Fusarium mycotoxin deoxynivalenol elicits hydrogen peroxide production, programmed cell death and defense responses in wheat ' () 9 Molecular Plant Pathology : 435 -445 .
-
Duncan, K.E. and Howard, R.J., 2010. Biology of maize kernel infection by Fusarium verticillioides. Molecular Plant-Microbe Interactions 23: 6-16.
-
Eaton, D.L., Beima, K.M., Bammler, T.K., Riley, R.T. and Voss, K.A., 2010. Hepatotoxic mycotoxins. In: Roth, R.A. and Ganey, P.E. (eds.) Comprehensive toxicology. Elsevier, Amsterdam, the Netherlands, pp. 527-569.
-
Fink-Gremmels, J. and Malekinejad, H., 2007. Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone. Animal Feed Science and Technology 137: 326-341.
'Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone ' () 137 Animal Feed Science and Technology : 326 -341 .
-
Foley, D.C., 1962. Systemic infection of corn by Fusarium moniliforme. Phytopathology 52: 870-872.
-
Fox, E.M. and Howlett, B.J., 2008. Secondary metabolism: regulation and role in fungal biology. Current Opinion in Microbiology 11: 481-487
'Secondary metabolism: regulation and role in fungal biology ' () 11 Current Opinion in Microbiology : 481 -487 .
-
Gardiner, S.A., Boddu, J., Berthiller, F., Hametner, C., Stupar, R.M., Adam, G. and Muehlbauer, G.J., 2010. Transcriptome analysis of the barley-deoxynivalenol interaction: evidence for a role of glutathione in deoxynivalenol detoxification. Molecular Plant-Microbe Interactions 23: 962-976.
'Transcriptome analysis of the barley-deoxynivalenol interaction: evidence for a role of glutathione in deoxynivalenol detoxification ' () 23 Molecular Plant-Microbe Interactions : 962 -976 .
-
Gilchrist, D.G., Ward, B., Moussato, V. and Mirocha, C.J., 1992. Genetic and physiological response to fumonisin and AAL-toxin in intact tissue of a higher plant. Mycopathologia 117: 57-64.
'Genetic and physiological response to fumonisin and AAL-toxin in intact tissue of a higher plant ' () 117 Mycopathologia : 57 -64 .
-
Glenn, A.E., 2007. Mycotoxigenic Fusarium species in animal feed. Animal Feed Science and Technology 137: 213-240.
-
Glenn, A.E., Zitomer, N.C., Zimeri, A.M., Williams, L.D., Riley, R.T. and Proctor, R.H., 2008. Transformation-mediated complementation of a FUM gene cluster deletion in Fusarium verticillioides restores both fumonisin production and pathogenicity on maize seedlings. Molecular Plant-Microbe Interactions 21: 87-97.
'Transformation-mediated complementation of a FUM gene cluster deletion in Fusarium verticillioides restores both fumonisin production and pathogenicity on maize seedlings ' () 21 Molecular Plant-Microbe Interactions : 87 -97 .
-
Groopman, J.D., Johnson, D. and Kensler, K.W., 2005. Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomarkers 1: 5-14.
'Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk ' () 1 Cancer Biomarkers : 5 -14 .
-
Groopman, J.D., Kensler, K.W. and Wild, C.P., 2008. Aflatoxin, hepatitis B virus and liver cancer: a paradigm for molecular epidemiology. In: Wild, C.P., Vineis, P. and Garte, S. (eds.) Molecular epidemiology of chronic diseases. John Wiley and Sons, Chichester, UK, pp. 323-342.
-
Harris, L.J., Desjardins, A.E., Plattner, R.D., Nicholson, P., Butler, G., Young, J.C., Weston, G., Proctor, R.H. and Hohn, T.M., 1999. Possible role of trichothecene mycotoxins in virulence of Fusarium graminearum on maize. Plant Disease 83: 954-960.
'Possible role of trichothecene mycotoxins in virulence of Fusarium graminearum on maize ' () 83 Plant Disease : 954 -960 .
-
Harvey, J.J., Lincoln, J.E. and Gilchrist, D.G., 2008. Programmed cell death suppression in transformed plant tissue by tomato cDNAs identified from an Agrobacterium rhizogenes-based functional screen. Molecular Genetics and Genomics 279: 509-521.
'Programmed cell death suppression in transformed plant tissue by tomato cDNAs identified from an Agrobacterium rhizogenes-based functional screen ' () 279 Molecular Genetics and Genomics : 509 -521 .
-
Howes, A.W., Dutton, M.F. and Chuturgoon, A.A., 1991. Metabolism of aflatoxin B1 by Petroselinum crispum (parsley). Mycopathologia 113: 25-29.
'Metabolism of aflatoxin B1 by Petroselinum crispum (parsley) ' () 113 Mycopathologia : 25 -29 .
-
Jansen, C., Von Wettstein, D., Schafer, W., Kogel, K.H., Felk, A. and Maier, F.J., 2005. Infection patterns in barley and wheat spikes inoculated with wild-type and trichodiene synthase gene disrupted Fusarium graminearum. Proceedings of the National Academy of Sciences of the USA 102: 16892-16897.
-
Kensler, T.W., Roebuck, B.D., Wogan, G.N. and Groopman, J.D. 2011. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences 120 Suppl. 1: S28-S48.
-
Kimura, M., Tokai, T., Takahashi-Ando, N., Ohsato, S. and Fujimura, M., 2007. Molecular and genetic studies of Fusarium trichothecene biosynthesis: pathways, genes, and evolution. Bioscience, Biotechnology, and Biochemistry 71: 2105-2123.
'Molecular and genetic studies of Fusarium trichothecene biosynthesis: pathways, genes, and evolution ' () 71 Bioscience, Biotechnology, and Biochemistry : 2105 -2123 .
-
Kommedahl, T. and Windels, C.E., 1981. Root-, stalk-, and ear-infecting Fusarium species on corn in the USA. In: Nelson, P.E., Toussoun, T.A. and Cook, R.J. (eds.) Fusarium: diseases, biology and taxonomy. The Pennsylvania State University Press, University Park, PA, USA, pp. 94-103.
'Root-, stalk-, and ear-infecting Fusarium species on corn in the USA ', in Fusarium: diseases, biology and taxonomy , () 94 -103 .
-
KoÅcielniak, J., Biesaga-KoÅcielniak, J., Janeczko, A., Filek, W. and Kalaji, H., 2009. Can the Gibberella zeae toxin zearalenone affect the photosynthetic productivity and increase yield formation in spring wheat and soybean plants? Photosynthetica 47: 586-594.
'Can the Gibberella zeae toxin zearalenone affect the photosynthetic productivity and increase yield formation in spring wheat and soybean plants ' () 47 Photosynthetica : 586 -594 .
-
Kuroyanagi, M., Yamada, K., Hatsugai, N., Kondo, M., Nishimura, M. and Hara-Nishimura, I., 2005. Vacuolar processing enzyme is essential for mycotoxin-induced cell death in Arabidopsis thaliana. Journal of Biological Chemistry 280: 32914-32920.
-
Kussak, A., Andersson, B., Andersson, K. and Nilsson C.-A., 1998. Determination of aflatoxicol in human urine by immunoaffinity column clean-up and liquid chromatography. Chemosphere 36: 1841-1848.
'Determination of aflatoxicol in human urine by immunoaffinity column clean-up and liquid chromatography ' () 36 Chemosphere : 1841 -1848 .
-
Lee, C.C., Liu, J.Y., Lin, J.K., Chu, J.S. and Shew, J.Y., 1998. p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions. Cancer Letters 125: 1-7.
'p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions ' () 125 Cancer Letters : 1 -7 .
-
Leslie, J.F., 1995. Gibberella fujikuroi: available populations and variable traits. Canadian Journal of Botany 73: S282-S291.
'Gibberella fujikuroi: available populations and variable traits ' () 73 Canadian Journal of Botany : S282 -S291 .
-
Leslie, J.F., Pearson, C.A.S., Nelson, P.E. and Toussoun, T.A., 1990. Fusarium spp. from corn, sorghum, and soybean fields in the central and eastern United States. Phytopathology 80: 343-350.
'Fusarium spp. from corn, sorghum, and soybean fields in the central and eastern United States ' () 80 Phytopathology : 343 -350 .
-
Leslie, J.F., Zeller, K.A., Logrieco, A., Mulè, G., Moretti, A. and Ritieni, A., 2004. Species diversity of and toxin production by Gibberella fujikuroi species complex strains isolated from native prairie grasses in Kansas. Applied and Environmental Microbiology 70: 2254-2262.
'Species diversity of and toxin production by Gibberella fujikuroi species complex strains isolated from native prairie grasses in Kansas ' () 70 Applied and Environmental Microbiology : 2254 -2262 .
-
Li, F., Asami, T., Wu, X., Tsang, E. and Cutler, A.J., 2007. A putative hydroxysteriod dehydrogenase involved in regulating plant growth and development. Plant Physiology 145: 87-97.
'A putative hydroxysteriod dehydrogenase involved in regulating plant growth and development ' () 145 Plant Physiology : 87 -97 .
-
Lin, S.S, Martin, R., Mongrand, S., Vandenabeele, S., Chen, K.C., Jang, I.C. and Chua, N.H., 2008. RING1 E3 ligase localizes to plasma membrane lipid rafts to trigger FB1-induced programmed cell death in Arabidopsis. The Plant Journal 56:550-561.
-
Liu, S., Zhang, X., Pumphrey, M.O., Stack, R.W., Gill, B.S. and Anderson, J.A., 2006. Complex microcolinearity among wheat, rice and barley revealed by fine mapping of the genomic region harboring a major QTL for resistance to Fusarium head blight in wheat. Functional and Integrative Genomics 6: 83-89.
'Complex microcolinearity among wheat, rice and barley revealed by fine mapping of the genomic region harboring a major QTL for resistance to Fusarium head blight in wheat ' () 6 Functional and Integrative Genomics : 83 -89 .
-
Logrieco, A., Mulè, G., Moretti, A. and Bottalico, A., 2002. Toxigenic Fusarium species and mycotoxins associated with maize ear rot in Europe. European Journal of Plant Pathology 108: 597-609.
'Toxigenic Fusarium species and mycotoxins associated with maize ear rot in Europe ' () 108 European Journal of Plant Pathology : 597 -609 .
-
Mally, A. and Dekant, W., 2009. Mycotoxins and the kidney: modes of action for renal tumor formation by ochratoxin A in rodents. Molecular Nutrition and Food Research 53: 467-478.
-
Mantle, P.G., Faucet-Marquis, V., Manderville, R.A., Squillaci, B. and Pfohl-Leszkowicz, A., 2010. Structures of covalent adducts between DNA and ochratoxin A: a new factor in debate about genotoxicity and human risk assessment. Chemical Research in Toxicology 23: 89-98.
-
Mariën, K., Moyer, R., Loveland, P., Van Holde, K. and Bailey, G., 1987. Comparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA. Journal of Biological Chemistry 262: 7455-7462.
'Comparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA ' () 262 Journal of Biological Chemistry : 7455 -7462 .
-
Marin-Kuan, M., Cavin, C., Delatour, T. and Schilter, B., 2008. Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms. Toxicon 52: 195-202.
'Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms ' () 52 Toxicon : 195 -202 .
-
Masuda, D., Ishida, M., Yamaguchi, K., Yamaguchi, I., Kimura, M. and Nishiuchi, T., 2007. Phytotoxic effects of trichothecenes on the growth and morphology of Arabidopsis thaliana. Journal of Experimental Botany 58: 1617-1626.
-
McLean, M., 1994a. Aflatoxin B1-induced ultrastructural alterations in mature Zea mays embryos. Mycopathologia 128: 181-192.
'Aflatoxin B1-induced ultrastructural alterations in mature Zea mays embryos ' () 128 Mycopathologia : 181 -192 .
-
McLean, M., 1994b. The phytotoxic effects of aflatoxin B1 â a review (1984-1994). South African Journal of Science 90: 385-390.
'The phytotoxic effects of aflatoxin B1 â a review (1984-1994) ' () 90 South African Journal of Science : 385 -390 .
-
McLean, M., Watt, M.P., Berjak, P. and Dutton, M.F., 1995. Aflatoxin B1 â its effects on an in vitro plant system. Food Additives and Contaminants 12: 435-443.
'Aflatoxin B1 â its effects on an in vitro plant system ' () 12 Food Additives and Contaminants : 435 -443 .
-
Munkvold, G.P., 2003. Epidemiology of Fusarium diseases and their mycotoxins in maize ears. European Journal of Plant Pathology 109: 705-713.
'Epidemiology of Fusarium diseases and their mycotoxins in maize ears ' () 109 European Journal of Plant Pathology : 705 -713 .
-
Norholm, M.H., Nour-Eldin, H.H., Brodersen, P., Mundy, J. and Haulkier, B.A., 2006. Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death. FEBS Letters 580: 2381-2387.
'Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death ' () 580 FEBS Letters : 2381 -2387 .
-
O'Brien, E. and Dietrich, D.R., 2005. Ochratoxin A: the continuing enigma. Critical Reviews in Toxicology 35: 33-60.
'Ochratoxin A: the continuing enigma ' () 35 Critical Reviews in Toxicology : 33 -60 .
-
O'Donnell, K., Cigelnik, E. and Nirenberg, H.I., 1998. Molecular systematics and phylogeography of the Gibberella fujikuroi species complex. Mycologia 90: 465-493.
'Molecular systematics and phylogeography of the Gibberella fujikuroi species complex ' () 90 Mycologia : 465 -493 .
-
Peng, X.-L., Xu, W.-T., Wang, Y., Huang, K.-L., Liang, Z.-H., Zhao, W.-W. and Luo, Y.-B., 2010. Mycotoxin ochratoxin A-induced cell death and changes in oxidative metabolism. Plant Cell Reports 29: 153-161.
-
Pestka, J.J., 2010a. Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin Journal 3: 323-347.
'Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol ' () 3 World Mycotoxin Journal : 323 -347 .
-
Pestka, J.J., 2010b. Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Archives of Toxicology 84: 663-679.
'Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance ' () 84 Archives of Toxicology : 663 -679 .
-
Pfohl-Leszkowicz, A. and Manderville, R.A., 2007. Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Molecular Nutrition and Food Research 51: 61-99.
-
Poppenberger, B., Berthiller, F., Lucyshyn, D., Sieberer, T., Schuhmacher, R., Krska, R., Kuchler, K., Glossl, J., Luschnig, C. and Adam, G., 2003. Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana. Journal of Biological Chemistry 278: 47905-47914.
-
Proctor, R.H., Hohn, T.M. and McCormick, S.P., 1995. Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Molecular Plant-Microbe Interactions 8: 593-601.
'Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene ' () 8 Molecular Plant-Microbe Interactions : 593 -601 .
-
Reverberi, M., Ricelli, A., Zjalic, S., Fabbri, A.A. and Fanelli, C., 2010. Natural functions of mycotoxins and control of their biosynthesis in fungi. Applied Microbiology and Biotechnology 87: 899-911.
'Natural functions of mycotoxins and control of their biosynthesis in fungi ' () 87 Applied Microbiology and Biotechnology : 899 -911 .
-
Riley, R.T., Voss, K.A., Coulombe, R.A., Pestka, J.J. and Williams, D.E., 2011. Developing mechanism-based and exposure biomarkers for mycotoxins in animals. In: De Saeger, S. (ed.) Determining mycotoxins and mycotoxigenic fungi in food and feed. Woodhead Publishing Limited, Cambridge, UK, pp. 245-275.
-
Rivkina, M.B., Cullen, J.M., Robinson, W.S. and Marion, P.L., 1994. State of p53 gene in hepatocellular carcinoma of ground squirrels and woodchucks with past and ongoing infection with hepadnavirus. Cancer Research 54: 5430-5437.
-
Routledge, M.N. and Gong, Y.Y., 2011. Developing biomarkers of human exposure to mycotoxins. In: De Saeger, S. (ed.) Determining mycotoxins and mycotoxigenic fungi in food and feed. Woodhead Publishing Limited, Cambridge, UK, pp. 225-244.
-
Scott, P.M., 2005. Biomarkers of human exposure to ochratoxin A. Food Additives and Contaminants 22 Suppl. 1: 99-107.
-
Shephard, G.S., Van der Westhuizen, L. and Sewram, V., 2007. Biomarkers of exposure to fumonisin mycotoxins: a review. Food Additives and Contaminants 24: 1196-1201.
'Biomarkers of exposure to fumonisin mycotoxins: a review ' () 24 Food Additives and Contaminants : 1196 -1201 .
-
Shi, L., Bielawski, J., Mu, J., Dong, H., Teng, C., Zhang, J., Yang, X., Tomishige, N., Hanada, K., Hannun, Y.A. and Zuo, J., 2007. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Research 17: 1030-1040.
-
Smela, M.E., Currier, S.S., Bailey, E.A. and Essigmann, J.M., 2001. The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis. Carcinogenesis 22: 535-545.
'The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis ' () 22 Carcinogenesis : 535 -545 .
-
Spassieva, S.D., Markham, J.E. and Hille, J., 2002. The plant disease resistance gene Asc-1 prevents disruption of sphingolipid metabolism during AAL-toxin-induced programmed cell death. The Plant Journal 32: 561-572.
'The plant disease resistance gene Asc-1 prevents disruption of sphingolipid metabolism during AAL-toxin-induced programmed cell death ' () 32 The Plant Journal : 561 -572 .
-
Tanaka, A., Tapper, B.A., Popay, A., Parker, E.J. and Scott, B., 2005. A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory. Molecular Microbiology 57: 1036-1050.
'A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory ' () 57 Molecular Microbiology : 1036 -1050 .
-
Tong, W.M., Lee, M.K., Galendo, D., Wang, Z.Q. and Sabapathy, K., 2006. Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock in) mice. International Journal of Cancer 119: 745-749.
'Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock in) mice ' () 119 International Journal of Cancer : 745 -749 .
-
Turner, P.C., 2010. Deoxynivalenol and nivalenol occurrence and exposure assessment. World Mycotoxin Journal 3: 315-321.
'Deoxynivalenol and nivalenol occurrence and exposure assessment ' () 3 World Mycotoxin Journal : 315 -321 .
-
Wang, H., Jones, C., Ciacci-Zanella, J.R., Holt, T., Gilchrist, D.G. and Dickman, M.B., 1996. Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. Proceedings of the National Academy of Sciences of the USA 93: 3461-3465.
'Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells ' () 93 Proceedings of the National Academy of Sciences of the USA : 3461 -3465 .
-
Watanabe, N. and Lam, E., 2006. Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death. The Plant Journal 45: 884-894.
'Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death ' () 45 The Plant Journal : 884 -894 .
-
White, D.G., 1999. Compendium of corn diseases. 3rd edition. APS Press, St. Paul, MN, USA.
-
Wild, C.P. and Gong, Y.Y., 2010. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis 31: 71-82.
'Mycotoxins and human disease: a largely ignored global health issue ' () 31 Carcinogenesis : 71 -82 .
-
Williams, L.D., Glenn, A.E., Bacon, C.W., Smith, M.A. and Riley, R.T., 2006. Fumonisin production and bioavailability to maize seedlings grown from seeds inoculated with Fusarium verticillioides and grown in natural soils. Journal of Agricultural and Food Chemistry 54: 5694-5700.
'Fumonisin production and bioavailability to maize seedlings grown from seeds inoculated with Fusarium verticillioides and grown in natural soils ' () 54 Journal of Agricultural and Food Chemistry : 5694 -5700 .
-
Williams, L.D., Glenn, A.E., Zimeri, A.M., Bacon, C.W., Smith, M.A. and Riley, R.T., 2007. Fumonisin disruption of ceramide biosynthesis in maize roots and the effects on plant development and Fusarium verticillioides-induced seedling disease. Journal of Agricultural and Food Chemistry 55: 2937-2946.
'Fumonisin disruption of ceramide biosynthesis in maize roots and the effects on plant development and Fusarium verticillioides-induced seedling disease ' () 55 Journal of Agricultural and Food Chemistry : 2937 -2946 .
-
Wolpert, T.J., Dunkle, L.D. and Ciuffetti, L.M., 2002. Host-selective toxins and avirulence determinants: what's in a name? Annual Review of Phytopathology 40: 251-285.
'Host-selective toxins and avirulence determinants: what's in a name ' () 40 Annual Review of Phytopathology : 251 -285 .
-
Wong, Z.A. and Hsieh, D.P., 1978. Aflatoxicol: major aflatoxin B1 metabolite in rat plasma. Science 200: 325-327.
'Aflatoxicol: major aflatoxin B1 metabolite in rat plasma ' () 200 Science : 325 -327 .
-
Zitomer, N.C., Glenn, A.E., Bacon, C.W. and Riley, R.T., 2008. A single extraction method for the analysis by liquid chromatography/ tandem mass spectrometry of fumonisins and biomarkers of disrupted sphingolipid metabolism in tissues of maize seedlings. Analytical and Bioanalytical Chemistry 391: 2257-2263.
'A single extraction method for the analysis by liquid chromatography/ tandem mass spectrometry of fumonisins and biomarkers of disrupted sphingolipid metabolism in tissues of maize seedlings ' () 391 Analytical and Bioanalytical Chemistry : 2257 -2263 .
-
Zitomer, N.C., Jones, S., Bacon, C., Glenn, A.E., Baldwin, T. and Riley, R.T., 2010. Translocation of sphingoid bases and their 1-phosphates, but not fumonisins, from roots to aerial tissues of maize seedlings watered with fumonisins. Journal of Agricultural and Food Chemistry 58: 7476-7481.
'Translocation of sphingoid bases and their 1-phosphates, but not fumonisins, from roots to aerial tissues of maize seedlings watered with fumonisins ' () 58 Journal of Agricultural and Food Chemistry : 7476 -7481 .
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The current state of mycotoxin biomarker development in humans and animals and the potential for application to plant systems
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Filamentous fungi that contaminate livestock feeds and human food supply often produce toxigenic secondary metabolites known as mycotoxins. Among the hundreds of known mycotoxins, aflatoxins, deoxynivalenol, fumonisins, ochratoxin A and zearalenone are considered the most commercially important. Intense research on these mycotoxins, especially aflatoxin, has resulted in the development of 'biomarkers' used to link exposure to disease risk. In the case of aflatoxin this effort has led to the discovery of both exposure and mechanism-based biomarkers, which have proven essential for understanding aflatoxin's potential for causing disease in humans, including subtle effects on growth and immune response. Fumonisin biomarkers have also been used extensively in farm and laboratory animals to study the fumonisin-induced disruption of cellular and systemic physiology which leads to disease. This review summarises the status of mycotoxin biomarker development in humans and animals for the commercially important mycotoxins. Since the fungi responsible for the production of these mycotoxins are often endophytes that infect and colonise living plant tissues, accumulation of mycotoxins in the plant tissues may at times be associated with development of plant disease symptoms. The presence of mycotoxins, even in the absence of disease symptoms, may still have subtle biological effects on the physiology of plants. This review examines the question of whether or not the knowledge gained from mechanistic studies and development of biomarkers in animal and human systems is transferable to the study of mycotoxin effects on plant systems. Thus far, fumonisin has proven amenable to development of mechanism-based biomarkers to study maize seedling disease caused by the fumonisin producer, Fusarium verticillioides. Expanding our knowledge of mechanisms of toxicity and the overt and subtle effects on animal, human, and plant systems through the identification and validation of biomarkers will further our ability to monitor and limit the damage and economic impact of mycotoxins.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 202 | 93 | 9 |
| å ¨ææµè§æ¬¡æ° | 18 | 1 | 0 |
| PDFä¸è½½æ¬¡æ° | 13 | 3 | 0 |
