Health effects of moniliformin: a poorly understood Fusarium mycotoxin
In: World Mycotoxin JournalSearch for other papers by K. Peltonen in
Current site
Google Scholar
Search for other papers by M. Jestoi in
Current site
Google Scholar
Search for other papers by G. Eriksen in
Current site
Google Scholar
The contamination of the food and feed chain with mycotoxins and the subsequent threat to human health and animal welfare is evident. Today mycotoxin research is still strongly focused on mycotoxins such as aflatoxins, ochratoxin A and for Fusarium fungi mainly the trichothecenes deoxynivalenol (DON) and T-2 and HT-2 toxins. However, fungi of the Fusarium genus are clearly capable of synthesising other mycotoxins as well, including moniliformin (MON). The occurrence of MON is worldwide and the levels in grains vary from below the limit of quantification to the highest detected value in maize intended for human consumption being close to 20 mg/kg. In Finland and Norway, the reported levels are typically a few hundreds of micrograms per kilogram. The toxicology of MON is not well understood. It is characterised by major species differences but typically MON evokes myocardiac damage. For MON, No Observed Adverse Effect Level (NOAEL) has not been established and a provisional Tolerable Daily Intake (pTDI) value has not been proposed. In our risk assessment, we applied a NOAEL value of 10 mg/kg bw/day which is based on our unpublished subchronic exposure experiments. By applying this value in the risk assessment combined with the estimated intakes from food in Finland and Norway, it seems that MON per se does not pose a clear threat to human health at current levels. On the other hand, one needs to bear in mind the concurrent exposure to other mycotoxins and the fact that the risk assessment of mycotoxin mixtures are in their infancy.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Abbas, H.K., Mirocha, C.J., Pawlosky, R.J. and Pusch, D.J., 1985. Effect of cleaning, milling, and baking on deoxynivalenol in wheat. Applied and Environmental Microbiology 50: 482-486.
'Effect of cleaning, milling, and baking on deoxynivalenol in wheat ' () 50 Applied and Environmental Microbiology : 482 -486 .
-
Abbas, H.K., Mirocha, C.J., Vesonder, R.F. and Gunther, R., 1990. Acute toxic effects of an isolate of moniliformin-producing Fusarium oxysporum and purified moniliformin on rats. Archives of Environmental Contaminantion and Toxicology 19: 433-436.
'Acute toxic effects of an isolate of moniliformin-producing Fusarium oxysporum and purified moniliformin on rats ' () 19 Archives of Environmental Contaminantion and Toxicology : 433 -436 .
-
Allen, N.K., Burmeister, H.R., Weaver, G.A. and Mirocha, C.J., 1981. Toxicity of dietary and intravenously administered moniliformin to broiler chickens. Poultry Science 60: 1415-1417.
'Toxicity of dietary and intravenously administered moniliformin to broiler chickens ' () 60 Poultry Science : 1415 -1417 .
-
Abramson, D., Clear, R.M., Gaba, D., Smith, D.M., Patrick, S.K. and Saydak, D., 2001. Trichothecene and moniliformin production by Fusarium species from Western Canadian wheat. Journal of Food Protection 64: 1220-1225.
'Trichothecene and moniliformin production by Fusarium species from Western Canadian wheat ' () 64 Journal of Food Protection : 1220 -1225 .
-
Adler, A., Lew, H., Brodacz, W., Edinger, W. and Oberforster, M., 1995. Occurrence of moniliformin, deoxynivalenol and zearalenone in durum wheat (Triticum durum Desf.). Mycotoxin Research 11: 9-15.
-
Beck, M.A., Levander, O.A. and Handy, J., 2003. Selenium deficiency and viral infection. Journal of Nutrition 133 Suppl.: 1463-1467.
'Selenium deficiency and viral infection ' () 133 Journal of Nutrition : 1463 -1467 .
-
Bermudez, A.J., Ledoux, D.D., Rottinghaus, G.E. and Bennet, G.A., 1997. The individual and combined effects of the Fusarium mycotoxins moniliformin and fumonisin B1 in turkeys. Avian Disease 41: 304-311.
'The individual and combined effects of the Fusarium mycotoxins moniliformin and fumonisin B1 in turkeys ' () 41 Avian Disease : 304 -311 .
-
Bernhoft, A., Claesen, P.-E., Kristofferssen, A.B. and Torp, M., 2010. Less Fusarium infestation and mycotoxin contamination in organic than in conventional cereals. Food Additives and Contaminants Part A 27: 842-852.
'Less Fusarium infestation and mycotoxin contamination in organic than in conventional cereals ' () 27 Food Additives and Contaminants Part A : 842 -852 .
-
Bullerman, L.B. and Blanchini, A., 2007. Stability of mycotoxins during food processing. International Journal of Food Microbiology 119: 140-146.
'Stability of mycotoxins during food processing ' () 119 International Journal of Food Microbiology : 140 -146 .
-
Burka, L.T., Doran, J. and Wilson, B.J., 1982. Enzyme inhibition and the toxic action of moniliformin and other vinylogous α-ketoacids. Biochemical Pharmacology 31: 79-84
'Enzyme inhibition and the toxic action of moniliformin and other vinylogous α-ketoacids ' () 31 Biochemical Pharmacology : 79 -84 .
-
Burmeister, H.R., Ciegler, A. and Vesonder, R.F., 1979. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Applied and Environmental Microbiology 37: 11-13.
'Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity ' () 37 Applied and Environmental Microbiology : 11 -13 .
-
Burmeister, H.R., Grove, M.D. and W.F. Kwolek, 1980. Moniliformin and butenolide: effect on mice of high-level, long-term oral intake. Applied and Environmental Microbiology 40: 1142-1144.
'Moniliformin and butenolide: effect on mice of high-level, long-term oral intake ' () 40 Applied and Environmental Microbiology : 1142 -1144 .
-
Caputo, A. and Munimbazi, C., 2002. Liquid chromatographic methods for moniliformin determination in corn tortillas and fate of the toxin during corn tortilla processing. 2002 Annual Meeting and Food Expo, Anaheim, CA, USA. Available at: http://Ift.Confex.Com/Ift/2002/Techprogram/Paper_11692.htm
-
Chelkowski, J., Zajkowki, P., Zawadzki, M. and Perkowski, J., 1987. Moniliformin, deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone -mycotoxins associated with corn cob fusariosis in Poland. Mycotoxin Research Special issue European seminar Fusarium-mycotoxins, taxomony, pathogenicity, 8-10 September 1987, Warsaw, Poland, pp. 25-27.
-
Chen, L.-Y., Tian, X.-L. and Yang, B., 1990. A study on the inhibition of rat myocardiium glutathione peroxidase and glutathione reductase by moniliformin. Mycopathologia 110: 119-124.
'A study on the inhibition of rat myocardiium glutathione peroxidase and glutathione reductase by moniliformin ' () 110 Mycopathologia : 119 -124 .
-
Cole, R.J. and Cox, R.H., 1981. Handbook of toxic fungal metabolites. Academic Press, New York, NY, USA, 937 pp.
-
Cole, R.J., Kirksey, J.W., Cutler, H.G., Doupink, B.L. and Peckham, J.C., 1973. Toxin from Fusarium moniliforme: effects on plants and animals. Science 179: 1324-1326.
'Toxin from Fusarium moniliforme: effects on plants and animals ' () 179 Science : 1324 -1326 .
-
Deruiter, J., Jacyno, J.M., Cutler, H.G. and Davis, R.A., 1993. Studies on aldose reductase inhibitors from fungi. II. Moniliformin and small ring analogues. Journal of Enzyme Inhibition 7: 249-256.
'Studies on aldose reductase inhibitors from fungi ' () 7 II. Moniliformin and small ring analogues. Journal of Enzyme Inhibition : 249 -256 .
-
Dombrink-Kurtzman, M.A., Javed, T., Bennett, G.A., Richard, J.L., Cote, L.M. and Buck, W.B., 1993. Lymphocyte cytotoxicity and erythrocytic abnormalities induced in broiler chicks by fumonisins B1 and B2 and moniliformin from Fusarium proliferatum. Mycopathologia 124: 47-54.
'Lymphocyte cytotoxicity and erythrocytic abnormalities induced in broiler chicks by fumonisins B1 and B2 and moniliformin from Fusarium proliferatum ' () 124 Mycopathologia : 47 -54 .
-
Edwards, S.G., 2009. Fusarium mycotoxin content of UK organic and conventional wheat. Food Additives and Contaminants Part A 26: 496-506.
'Fusarium mycotoxin content of UK organic and conventional wheat ' () 26 Food Additives and Contaminants Part A : 496 -506 .
-
Engelhardt, J.A., Carlton, W.W. and Tuite, J.F., 1989. Toxicity of Fusarium moniliforme var. subglutinans for chicks, ducklings and turkey poults. Avian Diseases 33: 357-360.
'Toxicity of Fusarium moniliforme var. subglutinans for chicks, ducklings and turkey poults ' () 33 Avian Diseases : 357 -360 .
-
Franck, B. and Breipohl, G., 1984. Biosynthesis of moniliformin, a fungal toxin with cyclobutanedione structure. Angewandte Chemie International Edition 24: 996-998.
'Biosynthesis of moniliformin, a fungal toxin with cyclobutanedione structure ' () 24 Angewandte Chemie International Edition : 996 -998 .
-
Gathercole, P.S., Thiel, P.G. and Hofmeyr, J.H.S., 1986. Inhibition of pyruvate dehydrogenase complex by moniliformin. Biochemical Journal 233: 719-723.
'Inhibition of pyruvate dehydrogenase complex by moniliformin ' () 233 Biochemical Journal : 719 -723 .
-
Gutleb, A-C., Morrison, E. and Murk, A.J., 2002. Cytotoxicity assays for mycotoxins produced by Fusarium strains: a review. Envionmental Toxicology and Pharmacology 11: 309-320.
'Cytotoxicity assays for mycotoxins produced by Fusarium strains: a review ' () 11 Envionmental Toxicology and Pharmacology : 309 -320 .
-
Gutema, T., Munimbazi, C. and Bullerman, L.B., 2000. Occurrence of fumonisins and moniliformin in corn and corn-based products of U.S. origin. Journal of Food Protection 63: 1732-1737.
'Occurrence of fumonisins and moniliformin in corn and corn-based products of U.S. origin ' () 63 Journal of Food Protection : 1732 -1737 .
-
Harvey, R.B., Edrington, T.S., Kubena, L.F., Rottinghaus, G.E., Turk, J.R., Genovese, K.J. and Nisbet D.J., 2001. Toxicity of moniliformin from Fusarium fujikuroi culture material to growing barrows. Journal of Food Protection 64: 1780-1784.
'Toxicity of moniliformin from Fusarium fujikuroi culture material to growing barrows ' () 64 Journal of Food Protection : 1780 -1784 .
-
Harvey, R.B., Edrington, T.S., Kubena, L.F., Rottinghaus, G.E., Turk, J.R., Genovese, K.J., Ziprin, R.L. and Nisbet, D.J., 2002. Toxicity of fumonisin from Fusarium verticillioides culture material and moniliformin from Fusarium fujikuroi culture material when fed singly and in combination to growing barrows. Journal of Food Protection 65: 373-377.
'Toxicity of fumonisin from Fusarium verticillioides culture material and moniliformin from Fusarium fujikuroi culture material when fed singly and in combination to growing barrows ' () 65 Journal of Food Protection : 373 -377 .
-
Hirvonen, T., Korhonen, T., Korkalo, L, Männistö, S., Ovaskainen, M.-L., Pakkala, H., Paturi, M., Pietinen, P., Reinivuo, H., Tapanainen, H. and Valsta, L., 2008. Finravinto 2007. The National FINDIET. National Public Health Publications B23, KVL, Helsinki, Finland.
-
Hood, R.D. and Szczech, G.M., 1983. Teratogenicity of fungal toxins and fungal-produced antimicrobial agents. In: Keeler, R.F. and Tu, A.T. (eds.) Handbook of natural toxins. Plant and fungal toxins Vol. 1. Marcel Dekker, Inc., New York, NY, USA, pp. 201-235.
-
Javed, T., Bennett, G.A., Richard, J.L., Dombrink-Kurtzman, M.A., Cote, L.M. and Buck, W.B., 1993. Mortality in broiler chicks on feed amended with Fusarium proliferatum culture material or with purified fumonisin B1 and moniliformin. Mycopathologia 123: 171-184.
'Mortality in broiler chicks on feed amended with Fusarium proliferatum culture material or with purified fumonisin B1 and moniliformin ' () 123 Mycopathologia : 171 -184 .
-
Jestoi, M., 2008. Emerging Fusarium-mycotoxins fusaproliferin, beauvericin, enniatins and moniliformin – a review. Critical Reviews in Food Science and Nutrition 48: 21-49.
'Emerging Fusarium-mycotoxins fusaproliferin, beauvericin, enniatins and moniliformin – a review ' () 48 Critical Reviews in Food Science and Nutrition : 21 -49 .
-
Jestoi, M. and Kokkonen, M., 2008. 'Uudet' Fusarium-mykotoksiinit suomalaisessa viljassa [Emerging Fusarium-mycotoxins in Finnish grains]. In: Hopponen, A. (ed.) Maataloustieteen Päivät 2008. Suomen Maataloustieteellisen Seuran tiedotteita no. 23. Available at: http://www.smts.fi
-
Jestoi, M., Rokka, M., Yli-Mattila, T., Parikka, P., Rizzo, A. and Peltonen, K., 2004a. Presence and concentrations of the Fusarium-related mycotoxins beauvericin, enniatins and moniliformin in Finnish grain samples. Food Additives and Contaminants 21: 794-802.
'Presence and concentrations of the Fusarium-related mycotoxins beauvericin, enniatins and moniliformin in Finnish grain samples ' () 21 Food Additives and Contaminants : 794 -802 .
-
Jestoi, M., Somma, M.C., Kouva, M., Veijalainen, P., Rizzo, A., Ritieni, A. and Peltonen, K., 2004b. Levels of mycotoxins and sample cytotoxicity of selected organic and conventional grain-based products purchased from Finnish and Italian markets. Molecular Nutrition and Food Research 48: 299-307.
'Levels of mycotoxins and sample cytotoxicity of selected organic and conventional grain-based products purchased from Finnish and Italian markets ' () 48 Molecular Nutrition and Food Research : 299 -307 .
-
Johansson, L. and Solvoll, K., 1999. Norkost 1997. Landsomfattende kostholdsundersøkelse blant menn og kvinner i alderen 16-79 år. Statens råd for ernæring og fysisk aktivitet, Oslo, Norway.
-
Knassműller, B., Bresgen, N., Kassie, F., Mersch-Sundermann, V., Gelderblom, W., Zührer, E. and Eckl, P.M., 1997. Genotoxic effects of three Fusarium mycotoxins fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes. Mutation Research 391: 39-48.
'Genotoxic effects of three Fusarium mycotoxins fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes ' () 39 Mutation Research : 39 -48 .
-
Knaflewsky, M., Golinski, P., Kostecki, M., Waskiewicz, A. and Weber, Z., 2008. Mycotoxins and mycotoxin-producing fungi occurring in asparagus spears. Acta Horticulturae 776: 183-189.
'Mycotoxins and mycotoxin-producing fungi occurring in asparagus spears ' () 776 Acta Horticulturae : 183 -189 .
-
Kokkonen, M., Ojala, L., Parikka, P. and Jestoi, M., 2010. Mycotoxin production of selected Fusarium species at different culture conditions. International Journal of Food Microbiology 143: 17-25.
'Mycotoxin production of selected Fusarium species at different culture conditions ' () 143 International Journal of Food Microbiology : 17 -25 .
-
Kostecki, M., Szczesna, J., Chelkowski, J. and Wisniewska, H., 1995. Beauvericin and moniliformin production by Polish isolates of Fusarium subglutinans and natural co-occurrence of both mycotoxins in maize samples. Microbiologie-Aliments-Nutrition 13: 67-70.
'Beauvericin and moniliformin production by Polish isolates of Fusarium subglutinans and natural co-occurrence of both mycotoxins in maize samples ' () 13 Microbiologie-Aliments-Nutrition : 67 -70 .
-
Kriek, N.P.J., Marasas, W.F.O., Steyn, P.S., Van Rensburg, S.J. and Steyn, M., 1977. Toxicity of a moniliformin-producing strain of Fusarium moniliforme var. subglutinans isolated from maize. Food and Cosmetics Toxicology 15: 579-587.
'Toxicity of a moniliformin-producing strain of Fusarium moniliforme var. subglutinans isolated from maize ' () 15 Food and Cosmetics Toxicology : 579 -587 .
-
Kubena, L.F., Harvey, R.B., Buckley, S.A., Bailey, R.H. and Rottinghaus, G.E., 1999. Effects of long-term feeding studies of diets containing moniliformin supplied by Fusarium fujikuroi culture material and fumonisin supplied by Fusarium moniliforme culture material to laying hens. Poultry Science 78: 1499-1505.
'Effects of long-term feeding studies of diets containing moniliformin supplied by Fusarium fujikuroi culture material and fumonisin supplied by Fusarium moniliforme culture material to laying hens ' () 78 Poultry Science : 1499 -1505 .
-
Kulik, T., 2008. Detection of Fusarium tricinctum from cereal grain using PCR assay. Journal of Applied Genetics 49: 305-311.
'Detection of Fusarium tricinctum from cereal grain using PCR assay ' () 49 Journal of Applied Genetics : 305 -311 .
-
Krysinska-Traczyk, W., Kiecana, I., Perkowski, J. and Dutkiewicz, J., 2001. Levels of fungi and mycotoxins in samples of grain and grain dust collected on farms in Eastern Poland. Annals of Agricultural and Environmental Medicine 8: 269-274.
'Levels of fungi and mycotoxins in samples of grain and grain dust collected on farms in Eastern Poland ' () 8 Annals of Agricultural and Environmental Medicine : 269 -274 .
-
Lamprecht, S.C., Marasas, W.F.O., Thiel, P.G., Schneider, D.J. and Know-Davis, P.S., 1986. Incidence and toxigenicity of seedborne Fusarium species from annual medicago species in South Africa. Phytopathology 76: 1040-1042.
'Incidence and toxigenicity of seedborne Fusarium species from annual medicago species in South Africa ' () 76 Phytopathology : 1040 -1042 .
-
Ledoux, D.R., Bermudez, A.J., Rottinghaus, G.E. and Broomhead, J., 1995. Effects of feeding Fusarium fujikuroi culture material, containing known levels of moniliformin, in young broiler chicks. Poultry Science 74: 297-305.
'Effects of feeding Fusarium fujikuroi culture material, containing known levels of moniliformin, in young broiler chicks ' () 74 Poultry Science : 297 -305 .
-
Lehtisalo, J., Erkkola, M., Tapanainen, H., Kronberg-Kippilä, C., Veijola, R., Knip, M. and Virtanen, S., 2010. Food consumption and nutrient intake in day care and at home in 3-year-old Finnish children. Public Health Nutrition 13: 957-964
'Food consumption and nutrient intake in day care and at home in 3-year-old Finnish children ' () 13 Public Health Nutrition : 957 -964 .
-
Leoni, L.A.B. and Soares, L.M.V., 2003. Survey of moniliformin in corn cultivated in the state of Sao Paulo and in corn products commercialized in the city of Campinas, S.P. Brazilian Journal of Microbiology 34: 13-15.
'Survey of moniliformin in corn cultivated in the state of Sao Paulo and in corn products commercialized in the city of Campinas, S.P. ' () 34 Brazilian Journal of Microbiology : 13 -15 .
-
Lew, H., Chelkowski, J., Wakulinski, W. and Edinger, W., 1993. Moniliformin in wheat and triticale grain. Mycotoxin Research 9: 66-71.
'Moniliformin in wheat and triticale grain ' () 9 Mycotoxin Research : 66 -71 .
-
Lew, H., Chelkowski, J., Pronczuk, P. and Edinger, W., 1996. Occurrence of the mycotoxin moniliformin in maize (Zea mays L.) ears infected by Fusarium subglutinans (Wollenw. & Reinking) Nelson et al. Food Additives and Contaminants 13: 321-324.
-
Li, Y.C., Ledoux, D.R., Bermudez, A.J., Fritsche, K.L. and Rottinghaus, G.E., 2000a. Effects of moniliformin on performance and immune function of broiler chicks. Poultry Science 79: 26-32.
'Effects of moniliformin on performance and immune function of broiler chicks ' () 79 Poultry Science : 26 -32 .
-
Li, Y.C., Ledoux, D.R., Bermudez, A.J., Fritsche, K.L. and Rottinghaus, G.E., 2000b. The individual and combined effects of fumonisin B1 and moniliformin on performance and selected immune parameters in turkey poults. Poultry Science 79: 871-878.
'The individual and combined effects of fumonisin B1 and moniliformin on performance and selected immune parameters in turkey poults ' () 79 Poultry Science : 871 -878 .
-
Logrieco, A., Moretti, A., Ritieni, A., Bottalico, A. and Corda, P., 1995. Occurrence and toxigenicity of Fusarium proliferatum from preharvest maize ear rot, and associated mycotoxins, in Italy. Plant Disease 79: 727-731.
'Occurrence and toxigenicity of Fusarium proliferatum from preharvest maize ear rot, and associated mycotoxins, in Italy ' () 79 Plant Disease : 727 -731 .
-
Ministry of Agriculture, Fisheries and Food (MAFF), 1998. Surveillance of moniliformin in maize, maize products and the effects of milling. Food Surveillance Information Sheet 164. MAFF, London, UK.
-
Morgan, M.K., Bursian, S.J., Rottinghaus, G.H., Bennet, G.A., Render, J.A. and Aulerich, R.J., 1998. Subacute and reproductive effects in mink from exposure to Fusarium fujikuroi culture material (M-1214) containing known concentrations on moniliformin. Archives of Environmental Contamination and Toxicology 35: 513-517.
'Subacute and reproductive effects in mink from exposure to Fusarium fujikuroi culture material (M-1214) containing known concentrations on moniliformin ' () 35 Archives of Environmental Contamination and Toxicology : 513 -517 .
-
Morgan, M.K., Fitzgerald, S.D., Rottinghaus, G.E., Bursian, S.J. and Aulerich, R.J., 1999. Toxic effects to mink of moniliformin extracted from Fusarium fujikuroi culture material. Veterinary and Human Toxicology 41: 1-5.
'Toxic effects to mink of moniliformin extracted from Fusarium fujikuroi culture material ' () 41 Veterinary and Human Toxicology : 1 -5 .
-
Morris, C.M., Li, Y.C., Ledoux, D.R., Bermudez, A.J. and Rottinghaus, G.E., 1999. The individual and combined effects of feeding moniliformin supplied by Fusarium fujikuroi culture material and deoxynivalenol in young turkey poults. Poultry Science 78: 1110-1115.
'The individual and combined effects of feeding moniliformin supplied by Fusarium fujikuroi culture material and deoxynivalenol in young turkey poults ' () 78 Poultry Science : 1110 -1115 .
-
Munimbazi, C. and Bullermann, L.B., 1998. High-performance liquid chromatographic method for the determination of moniliformin in corn. Journal of AOAC International 81: 999-1004.
'High-performance liquid chromatographic method for the determination of moniliformin in corn ' () 81 Journal of AOAC International : 999 -1004 .
-
Nagaraj, R.Y., Wu, W., Will, J.A. and Vesonder, R.F., 1996. Acute cardiotoxicity of moniliformin in broiler chickens as measured by electrocardiography. Avian Diseases 40: 223-227.
'Acute cardiotoxicity of moniliformin in broiler chickens as measured by electrocardiography ' () 40 Avian Diseases : 223 -227 .
-
Niessen, L.M., 1993. Entwicklung und Anwendung immunchemischer Verfahren zum Nachweis wichtiger Fusarium-toxine bei der Bierbereitung sowie mykologische Untersuchungen in Zusammenhang mit dem Wildwerden (Gushing) von Bieren. Doctoral Thesis, Technical University Munich, Munich, Germany.
-
Norred, W.P., Plattner, R.D., Vesonder, R.F., Bacon, C.W. and Voss, K.A., 1992. Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes. Food Chemical Toxicology 30: 233-237.
'Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes ' () 30 Food Chemical Toxicology : 233 -237 .
-
Noser, J., Wenk, P., Sutter, A., Frankhauser, I. and Hirschi, H., 2001. Fumonisine B1 und B2, Moniliformin, Beauvericin und Zearalenon in Mais auf dem Schweizer Markt. Mitteilungen aus Lebensmitteluntersuchung und Hygiene 92: 90-103.
'Fumonisine B1 und B2, Moniliformin, Beauvericin und Zearalenon in Mais auf dem Schweizer Markt ' () 92 Mitteilungen aus Lebensmitteluntersuchung und Hygiene : 90 -103 .
-
Organisation for Economic Development (OECD), 2001. OECD guidelines for testing of chemicals 423: acute oral toxicity – acute toxic class method. OECD, Paris, France.
-
Organisation for Economic Development (OECD), 2008. OECD guidelines for testing of chemicals 407: repeated dose 28-day oral toxicity study in rodents. OECD, Paris, France.
-
Pineda-Valdes, G. and Bullerman, L.G., 2000. Thermal stability of moniliformin at varying temperature, pH and time in an aqueous environment. Journal of Food Protection 63: 1598-1601.
'Thermal stability of moniliformin at varying temperature, pH and time in an aqueous environment ' () 63 Journal of Food Protection : 1598 -1601 .
-
Pineda-Valdes, G., Ryu, D., Hanna, M.A. and Bullerman, L.B., 2003. Reduction of moniliformin in corn by heat processing. Journal of Food Science 68: 1031-1035
'Reduction of moniliformin in corn by heat processing ' () 68 Journal of Food Science : 1031 -1035 .
-
Pineda-Valdes, G., Ryu, D., Jackson, D.S. and Bullerman, L.B., 2002. Reduction of moniliformin during alkaline cooking of corn. Cereal Chemistry 79: 779-782.
'Reduction of moniliformin during alkaline cooking of corn ' () 79 Cereal Chemistry : 779 -782 .
-
Pirrung, M.C. and Nauhaus, S.K., 1996. Cofactor-directed, time-dependent inhibition of thiamine enzymes by the fungal toxin moniliformin. Journal of Organic Chemistry 61: 2592-2593.
'Cofactor-directed, time-dependent inhibition of thiamine enzymes by the fungal toxin moniliformin ' () 61 Journal of Organic Chemistry : 2592 -2593 .
-
Reams, R.Y., Thacker, H.L., Harrington, D.D., Novilla, M.N., Rottinghaus, G.E., Bennett, G.A. and Horn, J., 1997. A sudden death syndrome induced in poults and chicks fed diets containing Fusarium fujikuroi with known concentrations of moniliformin. Avian Disease 41: 20-35.
'A sudden death syndrome induced in poults and chicks fed diets containing Fusarium fujikuroi with known concentrations of moniliformin ' () 41 Avian Disease : 20 -35 .
-
Rheeder, J.P., Sydenham, E.W., Marasas, W.F.O., Thiel, P.G., Shephard, G.S., Schlecter, M., Stockenstrom, S., Cronje, D.E. and Viljoen, J.H., 1994. Ear-rot fungi and mycotoxins in South African corn of the 1989 crop exported to Taiwan. Mycopathologia 127: 35-41.
'Ear-rot fungi and mycotoxins in South African corn of the 1989 crop exported to Taiwan ' () 127 Mycopathologia : 35 -41 .
-
Schwarz, P.B., Casper, H.H. and Beattie, S., 1995. Fate and development of naturally occurring Fusarium mycotoxins during malting and brewing. Journal of the American Society of Brewing Chemists 53: 121-127.
'Fate and development of naturally occurring Fusarium mycotoxins during malting and brewing ' () 53 Journal of the American Society of Brewing Chemists : 121 -127 .
-
Scott, P.M. and Lawrence, G.A., 1987. Liquid chromatographic determination and stability of the Fusarium mycotoxin moniliformin in cereal grains. Journal of AOAC International 70: 850-853.
'Liquid chromatographic determination and stability of the Fusarium mycotoxin moniliformin in cereal grains ' () 70 Journal of AOAC International : 850 -853 .
-
Scudamore, K.A., Banks, J.N. and Guy, R.C.E., 2004. Fate of ochratoxin A in the processing of whole wheat grain during extrusion. Food Additives and Contaminants 21: 488-497.
'Fate of ochratoxin A in the processing of whole wheat grain during extrusion ' () 21 Food Additives and Contaminants : 488 -497 .
-
Sewram, V., Nieuwoudt, T.W., Marasas, W.F.O., Shephard, G.S. and Ritieni, A., 1999. Determination of the mycotoxin moniliformin in cultures of Fusarium subglutinans and in naturally contaminated maize by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Journal of Chromatography A 848: 185-191.
'Determination of the mycotoxin moniliformin in cultures of Fusarium subglutinans and in naturally contaminated maize by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry ' () 848 Journal of Chromatography A : 185 -191 .
-
Sharma, D., Asrani, R.K., Ledoux, D.R., Jindal, N., Rottinghaus, G.E. and Gupta, V.K., 2008. Individual and combined effects of fumonisin B1 and moniliformin on clinicopathological and cell-mediated immune response in Japanese quail. Poultry Science 87: 1039-1051.
'Individual and combined effects of fumonisin B1 and moniliformin on clinicopathological and cell-mediated immune response in Japanese quail ' () 87 Poultry Science : 1039 -1051 .
-
Sharman, M., Gilbert, J. and Chelkowski, J., 1991. A survey of the occurrence of the mycotoxin moniliformin in cereal samples from sources worldwide. Food Additives and Contaminants 8: 459-466.
'A survey of the occurrence of the mycotoxin moniliformin in cereal samples from sources worldwide ' () 8 Food Additives and Contaminants : 459 -466 .
-
Sørensen, J.L., Phipps, R.K., Nielsen, K.F., Schroers, H.J., Frank, J. and Thrane, U., 2009. Analysis of Fusarium avenaceum metabolites produced during wet apple core rot. Journal of Agricultural and Food Chemistry 57: 1632-1639.
'Analysis of Fusarium avenaceum metabolites produced during wet apple core rot ' () 57 Journal of Agricultural and Food Chemistry : 1632 -1639 .
-
Sydenham, E.W., Thiel, P.G., Marasas, W.F.O., Shephard, G.S., Schalkwyk, D.J. and Koch K.R., 1990. Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, southern Africa. Journal of Agricultural and Food Chemistry 38: 1900-1903.
'Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, southern Africa ' () 38 Journal of Agricultural and Food Chemistry : 1900 -1903 .
-
Thalmann, A., Matzenauer, S. and Gruber, S., 1985. Survey on the occurrence of fusariotoxins in cereals. Berichte über Landwirtschaft 63: 257-272.
'Survey on the occurrence of fusariotoxins in cereals ' () 63 Berichte über Landwirtschaft : 257 -272 .
-
Thiel, P.G., 1978. A molecular mechanism for the toxic action of moniliformin, a mycotoxin produced by Fusarium moniliforme. Biochemical Pharmacology 27: 483-486.
-
Thiel, P.G., Meyer, C.J. and Marasas, W.F.O., 1982. Natural occurrence of moniliformin together with deoxynivalenol and zearalenone in Transkeian corn. Journal of Agricultural and Food Chemistry 30: 308-312.
'Natural occurrence of moniliformin together with deoxynivalenol and zearalenone in Transkeian corn ' () 30 Journal of Agricultural and Food Chemistry : 308 -312 .
-
Uhlig, S., Torp, M., Jarp, J., Parich, A., Gutleb, A.C. and Krska, R., 2004. Moniliformin in Norwegian grain. Food Additives and Contaminants 21: 598-606.
'Moniliformin in Norwegian grain ' () 21 Food Additives and Contaminants : 598 -606 .
-
Visconti, A., Minervini, F., Lucivero, G. and Gambatesa, V., 1991. Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay. Mycopathologia 113: 181-186.
'Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay ' () 113 Mycopathologia : 181 -186 .
-
Wehner, F.C., Marasas, W.F.O. and Thiel, P.G., 1978. Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins. Applied and Environmental Microbiology 35: 659-662.
'Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins ' () 35 Applied and Environmental Microbiology : 659 -662 .
-
Wu, W. and Vesonder, R.F., 1997a. Inhibition of gluconeogeneis in cultured chicken embryo hepatocytes by Fusarium metabolites. Natural Toxins 5: 80-85.
-
Wu, W. and Vesonder, R.F., 1997b. Moniliformin but not fumonisin B1 induced cardiomegaly and elevated serum lactate in broilers. Poultry Science 76 Suppl. 1: 126.
-
Wu, W., Liu, T. and Vesonder, R.F., 1995. Comparative cytotoxicity of fumonisin B1 and moniliformin in chicken primary cell cultures. Mycopathologia 132: 111-116.
'Comparative cytotoxicity of fumonisin B1 and moniliformin in chicken primary cell cultures ' () 132 Mycopathologia : 111 -116 .
-
Yu, S.-R., Liu, X.-J., Wang, Y.-H. and Liu, J., 1995. A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. Biomedical and Environmental Sciences 8: 330-334.
'A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China ' () 8 Biomedical and Environmental Sciences : 330 -334 .
-
Zhao, D., Feng, Q., Yan, X., Li, C., Pan, Y. and Cui, Q., 1993. Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice. Biomedical and Environmental Sciences 6: 37-44
'Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice ' () 6 Biomedical and Environmental Sciences : 37 -44 .
-
Zhu, L.Z., Xia, Y.M. and Yang, G.Q., 1982. Blood glutathione peroxidase activities of populations in Keshan disease affected and non-affected areas. Acta Nutrimenta Sinica 4: 229-233.
'Blood glutathione peroxidase activities of populations in Keshan disease affected and non-affected areas ' () 4 Acta Nutrimenta Sinica : 229 -233 .
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 334 | 166 | 25 |
| Full Text Views | 40 | 6 | 0 |
| PDF Views & Downloads | 36 | 18 | 0 |
Health effects of moniliformin: a poorly understood Fusarium mycotoxin
In: World Mycotoxin JournalSearch for other papers by K. Peltonen in
Current site
Google Scholar
PubMed
Search for other papers by M. Jestoi in
Current site
Google Scholar
PubMed
Search for other papers by G. Eriksen in
Current site
Google Scholar
PubMed
The contamination of the food and feed chain with mycotoxins and the subsequent threat to human health and animal welfare is evident. Today mycotoxin research is still strongly focused on mycotoxins such as aflatoxins, ochratoxin A and for Fusarium fungi mainly the trichothecenes deoxynivalenol (DON) and T-2 and HT-2 toxins. However, fungi of the Fusarium genus are clearly capable of synthesising other mycotoxins as well, including moniliformin (MON). The occurrence of MON is worldwide and the levels in grains vary from below the limit of quantification to the highest detected value in maize intended for human consumption being close to 20 mg/kg. In Finland and Norway, the reported levels are typically a few hundreds of micrograms per kilogram. The toxicology of MON is not well understood. It is characterised by major species differences but typically MON evokes myocardiac damage. For MON, No Observed Adverse Effect Level (NOAEL) has not been established and a provisional Tolerable Daily Intake (pTDI) value has not been proposed. In our risk assessment, we applied a NOAEL value of 10 mg/kg bw/day which is based on our unpublished subchronic exposure experiments. By applying this value in the risk assessment combined with the estimated intakes from food in Finland and Norway, it seems that MON per se does not pose a clear threat to human health at current levels. On the other hand, one needs to bear in mind the concurrent exposure to other mycotoxins and the fact that the risk assessment of mycotoxin mixtures are in their infancy.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 334 | 166 | 25 |
| Full Text Views | 40 | 6 | 0 |
| PDF Views & Downloads | 36 | 18 | 0 |
