Bennett, J.W. and Klich, M, 2003. Mycotoxins. Clinical Microbiology Reviews 16: 497-516.https://doi.org/10.1128/CMR.16.3.497-516.2003

Bracarense, A.P.F., Basso, K.M., Da Silva, E.O., Payros, D. and Oswald, I.P., 2017. Deoxynivalenol in the liver and lymphoid organs of rats: effects of dose and duration on immunohistological changes. World Mycotoxin Journal 10: 89-96.https://doi.org/10.3920/WMJ2016.2094

Cao, Z., Huang, W., Sun, Y. and Li, Y., 2020. Deoxynivalenol induced spermatogenesis disorder by blood-testis barrier disruption associated with testosterone deficiency and inflammation in mice. Environmental Pollution 264: 114748.https://doi.org/10.1016/j.envpol.2020.114748

Chacur, M.G.M., Ibrahim, D.B., Arrebola, T.A.H., Sanches, O.C., Giuffrida, R., Oba, E. and Ramos, A.A, 2015. Avaliação da técnica de coloração AgNOR em testículos de ovinos. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 67: 447-454.https://doi.org/10.1590/1678-6695

Cheng, C.Y. and Mruk, D., 2002. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiological Reviews 82: 825-874.https://doi.org/10.1152/physrev.00009.2002

Cheng, C.Y. and Mruk, D., 2012. The blood-testis barrier and its implications for male contraception. Pharmacological Reviews 64: 16-64.https://doi.org/10.1124/pr.110.002790

Clark, E.S., Flannery, B.M. and Pestka, J.J., 2015. Murine anorectic response to deoxynivalenol (vomitoxin) is sex-dependent. Toxins 7: 2845-2859.https://doi.org/10.3390/toxins7082845

Clermont, Y., 1972. Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiological Reviews 52: 198-236.https://doi.org/10.1152/physrev.1972.52.1.198

Diamanti-Kandarakis, E. and Gore, A.C., 2011. Endocrine disruptors and puberty. Springer Science & Business Media, New York, NY, USA.https://doi.org/10.1007-978-1-60761-561-3

Eriksen, G.S. and Pettersson, H., 2004. Toxicological evaluation of trichothecenes in animal feed. Animal Feed Science Technology 114: 205-239.https://doi.org/10.1016/j.anifeedsci.2003.08.008

Eze, U.A., Huntriss, J., Routledge, M.N. and Gong, Y.Y., 2018. Toxicological effects of regulated mycotoxins and persistent organochloride pesticides:in vitro cytotoxic assessment of single and defined mixtures on MA-10 murine Leydig cell line. Toxicology in Vitro 48: 93-103.https://doi.org/10.1016/j.tiv.2017.12.019

Favareto, A.P., Fernandez, C.D., Da Silva, D.A., Anselmo-Franci, J.A. and Kempinas, W.G., 2011. Persistent impairment of testicular histology and sperm motility in adult rats treated with Cisplatin at peri-puberty. Basic and Clinical Pharmacology and Toxicology 109: 85-96.https://doi.org/10.1111/j.1742-7843.2011.00688.x

Franca, L.R., Avelar, G.F. and Almeida, F.F., 2005. Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs. Theriogenology 63: 300-318.https://doi.org/10.1016/j.theriogenology.2004.09.014

Gonçalves, G.D., Vieira, N.A., Vieira, H.R., Valerio, A.D., Siervo, G.E.M.L., Pinheiro, P.F.F., Martinez, F.E., Guarnier, F.A., Teixeira, G.R. and Fernandes, G.S.A., 2017. Role of resistance physical exercise in preventing testicular damage caused by chronic ethanol consumption in UChB rats. Microscopy Research and Technique 80: 378-386.https://doi.org/10.1002/jemt.22806

Grenier, B. and Applegate, T.J., 2013. Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals. Toxins 5: 396-430.https://doi.org/10.3390/toxins5020396

Guerra, M.T., Sanabria, M., Leite, G.A., Borges, C.S., Cucielo, M.S., Anselmo-Franci, J.A., Foster, W.G. and Kempinas, W.G., 2017. Maternal exposure to butyl paraben impairs testicular structure and sperm quality on male rats. Environmental Toxicology 32: 1273-1289.https://doi.org/10.1002/tox.22323

Khoury, D.E., Fayjaloun, S., Nassar, M., Sahakian, J. and Aad, P.Y., 2019. Updates on the effect of mycotoxins on male reproductive efficiency in mammals. Toxins 11: 515.https://doi.org/10.3390/toxins11090515

Lattanzio, V.M.T., Solfrizzo, M., De Girolamo, A., Chulze, S.N., Torres, A.M. and Visconti, A., 2011. LC-MS/MS characterization of the urinary excretion profile of the mycotoxin deoxynivalenol in human and rat. Journal of Chromatography B 879: 707-715.https://doi.org/10.1016/j.jchromb.2011.01.029

Leblond, C.P. and Clermont, Y., 1952. Spermiogenesis of rat, mouse, hamster and guinea pig as revealed by the periodic acid-fuchsin sulfurous acid technique. American Journal of Anatomy 90: 167-215.https://doi.org/10.1002/aja.1000900202

Lee, H.J. and Ryu, D., 2017. Worldwide occurrence of mycotoxins in cereals and cereal-derived food products: public health perspectives of their co-occurrence. Journal of Agricultural and Food Chemistry 65: 7034-7051.https://doi.org/10.1021/acs.jafc.6b04847

Maresca, M., 2013. From the gut to the brain: journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol. Toxins 5: 784-820.https://doi.org/10.3390/toxins5040784

McCormick, S.P., Stanley, A.M., Stover, N.A. and Alexander, N.J., 2011. Trichothecenes: from simple to complex mycotoxins. Toxins 3: 802-814.https://doi.org/10.3390/toxins3070802

Mishra, S., Dixit, S., Dwivedi, P.D., Pandey, H.P. and Das, M., 2014. Influence of temperature and pH on the degradation of deoxynivalenol (DON) in aqueous medium: comparative cytotoxicity of DON and degraded product. Food Additives and Contaminants Part A 31: 121-131.https://doi.org/10.1080/19440049.2013.861613

Mruk, D.D. and Cheng, C.Y., 2015. The mammalian blood-testis barrier: its biology and regulation. Endocrine Reviews 36: 564-591.https://doi.org/10.1210/er.2014-1101

Nassr, A.C., Arena, A.C., Toledo, F.C., Bissacot, D.Z., Fernandez, C.D., Spinardi-Barbisan, A.L., Pires, P.W. and Kempinas, W.G., 2010. Effects of gestational and lactational fenvalerate exposure on immune and reproductive systems of male rats. Journal of Toxicology and Environmental Health Part A 73: 952-964.https://doi.org/10.1080/15287391003751745

Ojeda, S.R., Andrews, W.W., Advis, J.P. and White, S.S., 1980. Recent advances in the endocrinology of puberty. Endocrine Reviews 1: 228-257.https://doi.org/10.1210/edrv-1-3-228

Papageorgiou, M., Wells, L., Williams, C., White, K., De Santis, B., Liu, Y., Debegnach, F., Miano, B., Moretti, G., Greetham, S., Brera, C., Atkin, S.L., Hardie, L.J. and Sathyapalan, T., 2018. Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents. Toxins 10: 50.https://doi.org/10.3390/toxins10020050

Pestka, J., 2007. Deoxynivalenol: toxicity, mechanisms, and animal health risks. Animal Feed Science and Technology 137: 283-298.https://doi.org/10.1016/j.anifeedsci.2007.06.006

Pestka, J.J. and Smolinski, A.T., 2005. Deoxynivalenol: toxicology and potential effects on humans. Journal of Toxicology and Environmental Health Part B 8: 39-69.https://doi.org/10.1080/10937400590889458

Pestka, J.J., Uzarski, R.L. and Islam, Z., 2005. Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. Toxicology 206: 207-219.https://doi.org/10.1016/j.tox.2004.08.020

Richmond, E.J. and Rogol, A.D., 2007. Male pubertal development and the role of androgen therapy. Nature Clinical Practice Endocrinology and Metabolism 3: 338-344.https://doi.org/10.1038/ncpendmet0450

Rissato, D.F., de Santi Rampazzo, A.P., Borges, S.C., Sousa, F.C., Busso, C., Buttow, N.C. and Natali, M.R.M., 2020. Chronic ingestion of deoxynivalenol-contaminated diet dose-dependently decreases the area of myenteric neurons and gliocytes of rats. Neurogastroenterology and Motility 32: e13770.https://doi.org/10.1111/nmo.13770

Rogol, A.D., Roemmich, J.N. and Clark, P.A., 2002. Growth at puberty. Journal of Adolescent Health 31: 192-200.https://doi.org/10.1016/S1054-139X(02)00485-8

Savard, C., Nogues, P., Boyer, A. and Chorfi, Y., 2016. Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions. Toxicology 341: 17-27.https://doi.org/10.1016/j.tox.2016.01.003

Siervo, G.E.M.L., Vieira, H.R., Ogo, FM, Fernandez, C.D.B., Gonçalves, G.D., Mesquita S.F.P., Anselmo-Franci, J.Ap., Cecchini, R., Guarnier F.A. and Fernandes, G.S.A., 2015. Spermatic and testicular damages in rats exposed to ethanol: influence of lipid peroxidation but not testosterone. Toxicology 330: 1-8.https://doi.org/10.1016/j.tox.2015.01.016

Silva, M.V., Pante, G.C., Romoli, J.C.Z., de Souza, A.P.M., da Rocha, G.H.O., Ferreira, F.D., Feijó, A.L.R., Moscardi, S.M.P., de Paula, K.R., Bando, E., Nerilo S.B. and Machinski Jr, M., 2018. Occurrence and risk assessment of population exposed to deoxynivalenol in foods derived from wheat flour in Brazil. Food Additives and Contaminants Part A 35: 546-554.https://doi.org/10.1080/19440049.2017.1411613

Sprando, R.L., Collins, T.F., Black, T.N., Olejnik, N., Rorie, J.I., Eppley, R.M. and Ruggles, D.I., 2005. Characterization of the effect of deoxynivalenol on selected male reproductive endpoints. Food and Chemical Toxicology 43: 623-635.https://doi.org/10.1016/j.fct.2004.12.017

Sprando, R.L., Pestka, J., Collins, T.F., Rorie, J., O’Donnell, M., Hinton, D. and Chirtel, S., 1999. The effect of vomitoxin (deoxynivalenol) on testicular morphology, testicular spermatid counts and epididymal sperm counts in IL-6KO [B6129-IL6 [TmlKopf] (IL-6 gene deficient)] and WT [B6129F2 (wild type to B6129-IL6 with an intact IL-6 gene)] mice. Food and Chemical Toxicology 37: 1073-1079.https://doi.org/10.1016/S0278-6915(99)00103-9

Su, L., Mruk, D.D. and Cheng, C.Y., 2011. Drug transporters, the blood-testis barrier, and spermatogenesis. Journal of Endocrinology 208: 207-223.https://doi.org/10.1677/JOE-10-0363

Tarulli, G.A., Stanton, P.G. and Meachem, S.J., 2012. Is the adult Sertoli cell terminally differentiated? Biology of Reproduction 87: 13, 1-11.https://doi.org/10.1095/biolreprod.111.095091

Teerds, K.J., and Huhtaniemi, I.P., 2015. Morphological and functional maturation of Leydig cells: from rodent models to primates. Human Reproduction Update 21: 310-328.https://doi.org/10.1093/humupd/dmv008

Urbanek, K.A., Habrowska-Gorczynska, D.E., Kowalska, K., Stanczyk, A., Domińska, K. and Piastowska-Ciesielska, A.W., 2018. Deoxynivalenol as potential modulator of human steroidogenesis. Journal of Applied Toxicology 38: 1450-1459.https://doi.org/10.1002/jat.3623

Van Haaster, L.H. and De Rooij, D.G., 1993. Spermatogenesis is accelerated in the immature Djungarian and Chinese hamster and rat. Biology of Reproduction 49: 1229-1235.https://doi.org/10.1095/biolreprod49.6.1229

Walker, W.H. and Cheng, J., 2005. FSH and testosterone signaling in Sertoli cells. Reproduction 130: 15-28.https://doi.org/10.1530/rep.1.00358

Xiao, X., Mruk, D.D., Wong, C.K. and Cheng, C.Y., 2014. Germ cell transport across the seminiferous epithelium during spermatogenesis. Physiology 29: 286-298.https://doi.org/10.1152/physiol.00001.2014

Yang, J.H., Wang, J.H., Guo, W.B., Ling, A.R., Luo, A.Q., Liu, D., Yang, X.L. and Zhao, Z.H., 2019. Toxic effects and possible mechanisms of deoxynivalenol exposure on sperm and testicular damage in Balb/c mice. Journal of Agricultural and Food Chemistry 67: 2289-2295.https://doi.org/10.1021/acs.jafc.8b04783

Zirkin, B.R. and Papadopoulos, V., 2018. Leydig cells: formation, function, and regulation. Biology of Reproduction 99: 101-111.https://doi.org/10.1093/biolre/ioy059