Risk characterisation of dietary exposure of aflatoxins (AFs), fumonisins (FBs), deoxynivalenol (DON), zearalenone (ZEA) in maize from Shandong Province was conducted in this study. A total of 520 maize samples were collected after harvesting in 2014 and 2015 from 26 selected villages in Shandong Province, China. A deterministic approach was used in the current study. The dietary intake data of maize was obtained from ‘Shandong Statistical Yearbook 2018’. The risk characterisation of FBs, DON, and ZEA was evaluated in 4 population groups (2 to 6-year-old children, standard adults, city adults and village adults) based on probable intake. 2 to 6-year-old children and adults were exposed to FBs (0.42 and 0.20 μg/kg body weight (bw)/day), DON (0.04 and 0.019 μg/kg bw/day), and ZEA (0.0024 and 0.0011 μg/kg bw/day) through mean maize consumption in diets, which was lower than the provisional maximum tolerable daily intake of each mycotoxin established by JECFA. Risk assessments showed a low risk for liver cancer due to consumption of aflatoxin B1 (0.027-0.21 cases per 100,000 persons per year) contaminated maize compared with China’s current liver cancer incidence of 24.6 cases per 100,000 persons per year.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
Abia, W.A., Warth, B., Sulyok, M., Krska, R., Tchana, A.N., Njobeh, P.B., Dutton, M.F. and Moundipa, P.F., 2013. Determination of multi-mycotoxin occurrence in cereals, nuts and their products in Cameroon by liquid chromatography tandem mass spectrometry (LC-MS/MS). Food Control 31: 438-453.https://doi.org/10.1016/j.foodcont.2012.10.006
Adetuniji, M.C., Atanda, O.O., Ezekiel, C.N., Dipeolu, A.O., Sva, U., Oyedepo, J. and Chilaka, C.A., 2014. Distribution of mycotoxins and risk assessment of maize consumers in five agro-ecological zones of Nigeria. European Food Research and Technology 239: 287-296.https://doi.org/10.1007/s00217-014-2221-0
Adetunji, M.C., Atanda, O.O. and Ezekiel, C.N., 2017. risk assessment of mycotoxins in stored maize grains consumed by infants and young children in Nigeria. Children 4: 58.https://doi.org/10.3390/children4070058
Battilani, P., Toscano, P., Van der Fels-Klerx, H.J., Moretti, A., Camardo, L.M., Brera, C., Rortais, A., Goumperis, T. and Robinson, T., 2016. Aflatoxin B1 contamination in maize in Europe increases due to climate change. Scientific Reports 6: 24328.https://doi.org/10.1038/srep24328
Benford, D., Bolger, P.M., Carthew, P., Coulet, M., DiNovi, M., Leblanc, J.C., Renwick, A.G., Setzer, W., Schlatter, J., Smith, B., Slob, W., Williams, G. and Wildemann, T., 2010. Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic. Food and Chemical Toxicology 48: S2-S24.
'Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic ' () 48 Food and Chemical Toxicology : S2 -S24.
Chappell, G., Pogribny, I.P., Guyton, K.Z. and Rusyn, I., 2016. Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: a systematic literature review. Mutation Research/Reviews in Mutation Research 768: 27-45.https://doi.org/10.1016/j.mrrev.2016.03.004
Chen, C., Mitchell, N.J., Gratz, J., Houpt, E.R., Gong, Y., Egner, P.A., Groopman, J., Riley, R., Showker, J., Svensen, E., Mduma, E., Patil, C. and Wu, F., 2018. Exposure to aflatoxin and fumonisin in children at risk for growth impairment in rural Tanzania. Environment International 115: 29-37.https://doi.org/10.1016/j.envint.2018.03.001
Chen, J-G. and Song, X-M., 2005. An evaluation on incident cases of liver cancer in China. Chinese Journal of Cancer Research 14: 28-31. [In Chinese with English abstract]
'An evaluation on incident cases of liver cancer in China ' () 14 Chinese Journal of Cancer Research : 28 -31.
Cirillo, T., Ritieni, A., Galvano, F. and Amodio, C.R., 2003. Natural co-occurrence of deoxynivalenol and fumonisins B1 and B2 in Italian marketed foodstuffs. Food Additives and Contaminants 20: 566-571.https://doi.org/10.1080/0265203031000098669
Covarelli, L., Beccari, G. and Salvi, S., 2011. Infection by mycotoxigenic fungal species and mycotoxin contamination of maize grain in Umbria, central Italy. Food and Chemical Toxicology 49: 2365-2369.https://doi.org/10.1016/j.fct.2011.06.047
Ding, X., Wu, L., Li, P., Zhang, Z., Zhou, H., Bai, Y., Chen, X. and Jiang, J., 2015. Risk assessment on dietary exposure to aflatoxin B1 in, post-harvest peanuts in the Yangtze river ecological region. Toxins 7: 4157-4174.https://doi.org/10.3390/toxins7104157
Duan C.X., Qin Z.H., Yang Z.H., Li W.X., Sun S.L., Zhu Z.D. and Wang X.M., 2016. Identification of pathogenicFusarium spp. causing maize ear rot and potential mycotoxin production in China. Toxins 8: 186.
'Identification of pathogenicFusarium spp ' () 8 Toxins : 186.
European Food Safety Authority (EFSA), 2005. Opinion of the scientific committee on a request from EFSA related to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA Journal 3: 282.
European Food Safety Authority (EFSA), 2007. Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to the potential increase of consumer health risk by a possible increase of the existing maximum level for aflatoxins in almonds, hazelnuts and pistachios and derived products. EFSA Journal 5: 446.
European Food Safety Authority (EFSA), 2014. Scientific opinion on the risks for human and animal health related to the presence of modified forms of certain mycotoxins in food and feed. EFSA Journal 12: 3916.
Feng, Y.Z., Lu, X.H., Tao, B., Pang, M.H., Liu, Y.C. and Dong, J.G., 2011. Natural occurrence of fumonisins B1 and B2 in corn from three main production provinces in China. Journal of Food Protection 74: 1374-1378.https://doi.org/10.4315/0362-028X.JFP-11-103
Franco, L.T., Petta, T., Rottinghaus, G.E., Bordin, K., Gomes, G.A. and Oliveira, C.A.F., 2019. Co-occurrence of mycotoxins in maize food and maize-based feed from small-scale farms in Brazil: a pilot study. Mycotoxin Research 35: 65-73.https://doi.org/10.1007/s12550-018-0331-4
Gao, X., Yin, S., Zhang, H., Han, C., Zhao, X. and Ji, R., 2011. Aflatoxin contamination of corn samples collected from six regions of China. Journal of Hygiene Research 40: 46.https://doi.org/10.1631/jzus.B1000265
Gong, H.Z., Ji, R., Li, Y.X., Zhang, H.Y., Li, B., Zhao, Y., Sun, L., Yu, F. and Yang, J., 2009. Occurrence of fumonisin B1 in corn from the main corn-producing areas of China. Mycopathologia 167: 31-36.https://doi.org/10.1007/s11046-008-9146-8
Han, Z., Nie, D., Ediage, E.N., Yang, X., Wang, J., Chen, B., Li, S., On, S.L.W., De Saeger, S. and Wu, A., 2014. Cumulative health risk assessment of co-occurring mycotoxins of deoxynivalenol and its acetyl derivatives in wheat and maize: case study, Shanghai, China. Food and Chemical Toxicology 74: 334-342.https://doi.org/10.1016/j.fct.2014.10.018
Hove, M., De Boevre, M., Lachat, C., Jacxsens, L., Nyanga, L.K. and De Saeger, S., 2016. Occurrence and risk assessment of mycotoxins in subsistence farmed maize from Zimbabwe. Food Control 69: 36-44.https://doi.org/10.1016/j.foodcont.2016.04.038
Huong, B.T.M., Tuyen, L.D., Tuan, D.H., Brimer, L. and Dalsgaard, A., 2016. Dietary exposure to aflatoxin B1, ochratoxin A and fumonisins of adults in Lao Cai province, Viet Nam: A total dietary study approach. Food and Chemical Toxicology 98: 127-133.https://doi.org/10.1016/j.fct.2016.10.012
International Agency for Research on Cancer (IARC), 1993. Toxins derived fromFusarium moniliforme: fumonisins B1 and B2 andFusarium C. IARC Monographs on the evaluation of carcinogenic risks to humans. Vol. 56. IARC Scientific Publications, Lyon, France, pp. 445.
International Agency for Research on Cancer (IARC), 2002. Aflatoxins (group 1). IARC Monographs on the evaluation of carcinogenic risks to humans. Vol. 82. IARC, Lyon, France, pp. 9-13.
International Agency for Research on Cancer (IARC), 2012. Improving public health through mycotoxin control. IARC Scientific Publication no. 158. IARC Press, Lyon, France.
Joint FAO/WHO Expert Committee on Food Additives (JECFA), 2011. Evaluation of certain food additives and contaminants seventy-fourth report of the Joint FAO/WHO Expert Committee on Food Additives. Introduction. Technical Report no. 940. FAO/WHO, Rome, Italy.
Kayode, O.F., Sulyok, M., Fapohunda, S.O., Ezekiel, C.N., Krska, R. and Oguntona, C.R., 2013. Mycotoxins and fungal metabolites in groundnut- and maize-based snacks from Nigeria. Food Additives and Contaminants Part B 6: 294-300.https://doi.org/10.1080/19393210.2013.823626
Kew, M.C., 2013. Aflatoxins as a cause of hepatocellular carcinoma. Journal of Gastrointestinal and Liver Diseases 22: 305-310.https://doi.org/10.1586/17474124.2013.832500
Kimanya, M.E., Shirima, C.P., Magoha, H., Shewiyo, D.H., De Meulenaer, B., Kolsteren, P. and Gong, Y.Y., 2014. Co-exposures of aflatoxins with deoxynivalenol and fumonisins from maize-based complementary foods in Rombo, northern Tanzania. Food Control 41: 76-81.
'Co-exposures of aflatoxins with deoxynivalenol and fumonisins from maize-based complementary foods in Rombo, northern Tanzania ' () 3 Food Control : 282 -13.
Li, R., Tao, B., Pang, M., Liu, Y. and Dong, J., 2015. Natural occurrence of fumonisins B1 and B2 in maize from three main maize-producing provinces in China. Food Control 50: 838-842.https://doi.org/10.1016/j.foodcont.2014.09.034
Liu, Z., Gao, J. and Yu, J., 2006. Aflatoxins in stored maize and rice grains in Liaoning Province, China. Journal of Stored Products Research 42: 468-479.https://doi.org/10.2307/40661599
Liu, Z., Zhang, G., Zhang, Y., Jin, Q., Zhao, J., and Li, J., 2016. Factors controlling mycotoxin contamination in maize and food in the Hebei province, China. Agronomy for Sustainable Development 36: 39.https://doi.org/10.1007/s13593-016-0374-x
Lombard, M.J., 2014. Mycotoxin exposure and infant and young child growth in Africa: what do we know? Annals of Nutrition and Metabolism 64, Suppl. 2: 42-52.
'Mycotoxin exposure and infant and young child growth in Africa: what do we know? ' () 2 Annals of Nutrition and Metabolism : 42 -52.
Mankevičienė, A., Butkutė, B., Gaurilčikienė, I., Dabkevičius, Z. and Supronienė, S., 2011. Risk assessment ofFusarium mycotoxins in Lithuanian small cereal grains. Food Control 22: 970-976.https://doi.org/10.1016/j.foodcont.2010.12.004
Marin, S., Ramos, A.J., Cano-Sancho, G. and Sanchis, V., 2013. Mycotoxins: occurrence, toxicology, and exposure assessment. Food and Chemical Toxicology 60: 218-237.https://doi.org/10.1016/j.fct.2013.07.047
National Bureau of Statistics of the People’s Republic of China (NBSPRC), 2014. National data. Available at:http://data.stats.gov.cn/easyquery.htm?cn=C01
Ortiz, J., Van Camp, J., Mestdagh, F., Donoso, S. and De Meulenaar, B., 2013. Mycotoxin co-occurrence in rice, oat flakes and wheat noodles used as staple foods in Ecuador. Food Additives and Contaminants Part A 30: 2165-2176.https://doi.org/10.1080/19440049.2013.853228
Raad, F., Nasreddine, L., Hilan, C., Bartosik, M. and Parent-Massin, D., 2014. Dietary exposure to aflatoxins, ochratoxin A and deoxynivalenol from a total diet study in an adult urban Lebanese population. Food and Chemical Toxicology 73: 35-43.https://doi.org/10.1016/j.fct.2014.07.034
Sarma, U.P., Bhetaria, P.J., Devi, P. and Varma, A., 2017. Aflatoxins: implications on health. Indian Journal of Clinical Biochemistry 32: 124-133.https://doi.org/10.1007/s12291-017-0649-2
Shi, H., Li, S., Bai, Y., Prates, L.L., Lei, Y. and Yu, P., 2018. Mycotoxin contamination of food and feed in China: occurrence, detection techniques, toxicological effects and advances in mitigation technologies. Food Control 91: 202-215.https://doi.org/10.1016/j.foodcont.2018.03.036
Stanciu, O., Banc, R., Cozma, A., Filip, L., Miere, D., Mañes, J. and Loghin, F., 2015. Occurrence ofFusarium mycotoxins in wheat from Europe – a review. Acta Universitatis Cibiniensis 19: 35-60.https://doi.org/10.1515/aucft-2015-0005
Sun, J. and Wu, Y., 2016. Evaluation of dietary exposure to deoxynivalenol (DON) and its derivatives from cereals in China. Food Control 69: 90-99.https://doi.org/10.1016/j.foodcont.2016.04.040
Sun, X.D., Su, P. and Shan, H., 2017. Mycotoxin contamination of maize in China. Comprehensive Reviews in Food Science and Food Safety 16: 835-849.https://doi.org/10.1111/1541-4337.12286
United States Food and Drugs Agency (US FDA), 2001. Guidance for industry: fumonisin levels in human foods and animal feeds. document FDA-2013-S-0610. US FDA, Washington, DC, USA.
Wang, J. and Liu, X.-M., 2008. Contamination of aflatoxins in different kinds of foods in China. Biomedical and Environmental Sciences 20: 483-487.
'Contamination of aflatoxins in different kinds of foods in China ' () 20 Biomedical and Environmental Sciences : 483 -487.
Wang, J., Zhou, Y., Liu, W., Zhu, X., Du, L. and Wang, Q., 2008. Fumonisin level in corn-based food and feed from Linxian County, a high-risk area for esophageal cancer in China. Food Chemistry 106: 241-246.https://doi.org/10.1016/j.foodchem.2007.05.076
Wang, W., Zhu, J., Shao, B. and Li, F., 2015. Probabilistic assessment of dietary exposure to both deoxynivalenol and zearalenone from cereal-based products in Chinese populations. Chinese Journal of Preventive Medicine 49: 223.
'Probabilistic assessment of dietary exposure to both deoxynivalenol and zearalenone from cereal-based products in Chinese populations ' () 49 Chinese Journal of Preventive Medicine : 223.
Wei, T., Zhu, W., Pang, M., Liu, Y. and Dong, J., 2013. Natural occurrence of fumonisins B1 and B2 in corn in four provinces of China. Food Additives and Contaminants Part B 6: 270-274.https://doi.org/10.1080/19393210.2013.819816
World Health Organisation/Food and Agriculture Organisation (WHO/FAO), 2018. Safety evaluation of certain contaminants in food: prepared by the eighty-third meeting of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organisation, Geneva, Switzerland. Available at:http://www.who.int/iris/handle/10665/276868
Xing, F., Liu, X., Wang, L., Selvaraj, J.N., Jin, N., Wang, Y., Zhao, Y. and Liu, Y., 2017. Distribution and variation of fungi and major mycotoxins in pre- and post-nature drying maize in North China Plain. Food Control 80: 244-251.https://doi.org/10.1016/j.foodcont.2017.03.055
Xu, Y., Gong, Y. and Routledge, M., 2018. Aflatoxin exposure assessed by aflatoxin albumin adduct biomarker in populations from six African countries. World Mycotoxin Journal 11: 411-419.https://doi.org/10.3920/WMJ2017.2284
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 399 | 100 | 10 |
| Full Text Views | 31 | 1 | 0 |
| PDF Views & Downloads | 17 | 1 | 0 |
Risk characterisation of dietary exposure of aflatoxins (AFs), fumonisins (FBs), deoxynivalenol (DON), zearalenone (ZEA) in maize from Shandong Province was conducted in this study. A total of 520 maize samples were collected after harvesting in 2014 and 2015 from 26 selected villages in Shandong Province, China. A deterministic approach was used in the current study. The dietary intake data of maize was obtained from ‘Shandong Statistical Yearbook 2018’. The risk characterisation of FBs, DON, and ZEA was evaluated in 4 population groups (2 to 6-year-old children, standard adults, city adults and village adults) based on probable intake. 2 to 6-year-old children and adults were exposed to FBs (0.42 and 0.20 μg/kg body weight (bw)/day), DON (0.04 and 0.019 μg/kg bw/day), and ZEA (0.0024 and 0.0011 μg/kg bw/day) through mean maize consumption in diets, which was lower than the provisional maximum tolerable daily intake of each mycotoxin established by JECFA. Risk assessments showed a low risk for liver cancer due to consumption of aflatoxin B1 (0.027-0.21 cases per 100,000 persons per year) contaminated maize compared with China’s current liver cancer incidence of 24.6 cases per 100,000 persons per year.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 399 | 100 | 10 |
| Full Text Views | 31 | 1 | 0 |
| PDF Views & Downloads | 17 | 1 | 0 |