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Deoxynivalenol: toxicological profiles and perspective views for future research

In: World Mycotoxin Journal
Authors:
H. Zhou College of Food Science, Southwest University, Tiansheng Road #2, Chongqing 400715, China P.R.

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T. Guog College of Food Science, Southwest University, Tiansheng Road #2, Chongqing 400715, China P.R.

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H. Dai College of Food Science, Southwest University, Tiansheng Road #2, Chongqing 400715, China P.R.

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Y. Yu College of Food Science, Southwest University, Tiansheng Road #2, Chongqing 400715, China P.R.

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Y. Zhang College of Food Science, Southwest University, Tiansheng Road #2, Chongqing 400715, China P.R.
Biological Science Research Center, Southwest University, Chongqing 26463, China P.R.

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L. Ma College of Food Science, Southwest University, Tiansheng Road #2, Chongqing 400715, China P.R.
Biological Science Research Center, Southwest University, Chongqing 26463, China P.R.

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Deoxynivalenol (DON) is a secondary metabolite mainly produced by the fungiFusarium in agricultural crops, widely existing in feeds and cereal-based foodstuffs. Because of the high occurrence and potentials to induce a variety of toxic effects on animals and humans, DON has been a very harmful exogenous dietary toxicant threating public health. The focus of this review is to summarise the DON-induced broad spectrum of adverse health effects, to probe the current state of knowledge of combined toxicity of DON with other mycotoxins and its derivatives, and to put forward prospective ideas that multi-generational toxicity of DON and its overall impacts on intestinal-immuno-neuroendocrine system could receive more attention in future investigations. The general aim is to provide a scientific basis for the necessity to re-consider risk-assessment and regulations.

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