Determination of multiple mycotoxins in Qatari population serum samples by LC-MS/MS
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Human exposure to mycotoxins is almost inevitable as mycotoxins are naturally occurring contaminants of large portion of food and feed. Depending on the type of mycotoxins, inter-individual mycotoxin adsorption, bioaccumulation, distribution, metabolism and excretion, can cause serious adverse health effects. Therefore, continuous biomonitoring studies of population exposure to mycotoxins are needed. Here we describe a multi-analyte approach for the detection and quantification of 20 mycotoxins in human serum using ultra-performance liquid chromatography-electrospray/tandem mass spectrometry operated in targeted multiple reaction monitoring mode. The validated method was used to assess occurrence of mycotoxins in serum samples of 46 residents of Qatar. Mycotoxins that were detected with high incidence were HT-2 toxin (13.0%), sterigmatocystin (10.9%) and 3-acetyldeoxynivalenol (6.5%). Also, co-exposure to several mycotoxins was noticed in the analysed samples. Our results show that strict food quality control is needed to remove mycotoxin contaminated food from the market in order to minimise human exposure to mycotoxins.
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Supplementary Materials
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Determination of multiple mycotoxins in Qatari population serum samples by LC-MS/MS
In: World Mycotoxin JournalSearch for other papers by B.A. Al-Jaal in
Current site
Google Scholar
PubMed
Search for other papers by A. Latiff in
Current site
Google Scholar
PubMed
Search for other papers by S. Salama in
Current site
Google Scholar
PubMed
Departments of Laboratory Medicine, University Medical Center Groningen, P.O. Box 30001, 9700 RB Groningen, the Netherlands.
Search for other papers by A. Barcaru in
Current site
Google Scholar
PubMed
Search for other papers by P. Horvatovich in
Current site
Google Scholar
PubMed
Search for other papers by M. Jaganjac in
Current site
Google Scholar
PubMed
Human exposure to mycotoxins is almost inevitable as mycotoxins are naturally occurring contaminants of large portion of food and feed. Depending on the type of mycotoxins, inter-individual mycotoxin adsorption, bioaccumulation, distribution, metabolism and excretion, can cause serious adverse health effects. Therefore, continuous biomonitoring studies of population exposure to mycotoxins are needed. Here we describe a multi-analyte approach for the detection and quantification of 20 mycotoxins in human serum using ultra-performance liquid chromatography-electrospray/tandem mass spectrometry operated in targeted multiple reaction monitoring mode. The validated method was used to assess occurrence of mycotoxins in serum samples of 46 residents of Qatar. Mycotoxins that were detected with high incidence were HT-2 toxin (13.0%), sterigmatocystin (10.9%) and 3-acetyldeoxynivalenol (6.5%). Also, co-exposure to several mycotoxins was noticed in the analysed samples. Our results show that strict food quality control is needed to remove mycotoxin contaminated food from the market in order to minimise human exposure to mycotoxins.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 355 | 121 | 10 |
| Full Text Views | 23 | 0 | 0 |
| PDF Views & Downloads | 20 | 0 | 0 |
