CHRONIC EXPOSURE TO DIFFERENT AMBIENT TEMPERATURES AFFECTS β-AR PROFILE AND HEART RESPONSIVENESS TO ISOPROTERENOL AND CALCIUM
In: Israel Journal of Ecology and EvolutionDepartment of Physiology, Hadassah School of Dental Medicine and Medicine, The Hebrew University of Jerusalemarieli_y@ucdavis.edu
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The purpose of this investigation was to study the effect of thermal acclimation on the myocardium of rock pigeons. We determined the density and affinity of the b -adrenergic receptors in the left ventricle of cold-, heat-, and normothermic-acclimated pigeons by radioligand binding techniques. The mechanical performance of the left ventricle of the heart subjected to either isoproterenol or Ca2+ loading was measured using the Langendorff perfusion system. Heat- and cold-acclimated hearts demonstrated a significant downregulation of b - and b2 -adrenoreceptor density accompanied by an increase in their affinity when compared with normothermic-acclimated hearts. In agreement with these results, isoproterenol improved cardiac performance in cold- and heat-acclimated hearts. We also found that the heat-acclimated hearts were capable of functioning successfully when exposed to high Ca2+ loads, whereas cold-acclimated hearts were significantly less tolerant of Ca2+ loads and less efficient. Thermal acclimation induces cellular alterations in the pigeon heart, thus enabling better coping with hemodynamic and calcium loads, both resulting from thermal stress.
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CHRONIC EXPOSURE TO DIFFERENT AMBIENT TEMPERATURES AFFECTS β-AR PROFILE AND HEART RESPONSIVENESS TO ISOPROTERENOL AND CALCIUM
In: Israel Journal of Ecology and EvolutionDepartment of Physiology, Hadassah School of Dental Medicine and Medicine, The Hebrew University of Jerusalemarieli_y@ucdavis.edu
Search for other papers by Yehuda Arieli in
Current site
Google Scholar
PubMed
Search for other papers by Pavel Kaspler in
Current site
Google Scholar
PubMed
Search for other papers by Michal Horowitz in
Current site
Google Scholar
PubMed
The purpose of this investigation was to study the effect of thermal acclimation on the myocardium of rock pigeons. We determined the density and affinity of the b -adrenergic receptors in the left ventricle of cold-, heat-, and normothermic-acclimated pigeons by radioligand binding techniques. The mechanical performance of the left ventricle of the heart subjected to either isoproterenol or Ca2+ loading was measured using the Langendorff perfusion system. Heat- and cold-acclimated hearts demonstrated a significant downregulation of b - and b2 -adrenoreceptor density accompanied by an increase in their affinity when compared with normothermic-acclimated hearts. In agreement with these results, isoproterenol improved cardiac performance in cold- and heat-acclimated hearts. We also found that the heat-acclimated hearts were capable of functioning successfully when exposed to high Ca2+ loads, whereas cold-acclimated hearts were significantly less tolerant of Ca2+ loads and less efficient. Thermal acclimation induces cellular alterations in the pigeon heart, thus enabling better coping with hemodynamic and calcium loads, both resulting from thermal stress.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 134 | 40 | 6 |
| Full Text Views | 9 | 0 | 0 |
| PDF Views & Downloads | 9 | 0 | 0 |
