HEMOGLOBIN-BASED O2 TRANSFER IN VIVIPAROUS ANIMALS
In: Israel Journal of Ecology and EvolutionSearch for other papers by ROY E. WEBER in
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The transfer of O2 from the maternal to prenatal circulation is facilitated by higher O2 affinities in prenatal blood. The affinity shifts that may compensate for lack or feeble development of placental connections result from different operating conditions for the Hb (such as lower concentrations of organic phosphates that depress Hb-O2 affinity in the fetal red cells), or the occurrence of specific fetal and embryonic Hb's that have either higher intrinsic O2 affinities than adult Hb or lower sensitivities to phosphate cofactors. The affinity shifts correlate with amino acid substitutions at very few, key positions in the Hb protein moieties and thus demonstrate conservatism in molecular strategies. The complex molecular systems encountered in early embryos may favor homeostasis in tissue O2 supply and compensate for their lower organization at the organ level compared to adults.
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-
Adachi K., Kim J., Asakura T., Schwartz E.Characterization of two types of fetal hemoglobin: α2Gγ2 and α2Aγ2 Blood 1990 75 2070 2075
-
Bard H., Fouron J.C., Prosmanne J., Gagnon J.Effect of hypoxemia on fetal hemoglobin synthesis during late gestation Pediatr. Res 1992 31 483 485
-
Bartels H., Baumann R., Respiratory function of hemoglobin. Respiratory physiology II, Vol 14 Widdicombe J.G.University Park Press BaltimoreMD 1977 107 134
-
Bartlett G.R.Phosphate compounds in red cells of two dogfish sharks: Squalus acanthias and Mustellus canis. Comp. Biochem. Physiol. A73: 1982 135 140
-
Battaglia F.C., Bowes W., McGaughey H., Makowski E.L., Meschia G.The effect of fetal exchange transfusions with adult blood upon fetal oxygenation Pediatr. Res 1969 3 60 65
-
Bauer C., Tamm R., Petschow D., Bartels R., Bartels H.Oxygen affinity and allosteric effects of embryonic mouse haemoglobins Nature 1975 257 333 334
-
Bauer C., Jelkmann W., Moll W.High oxygen affinity of maternal blood reduces fetal weight in rats Respir. Physiol 1981 43 169 178
-
Baumann R.Po2-dependent hormonal control of avian embryonic red cell carbonic anhydrase II synthesis, organic phosphate pattern, and oxygen affinity Isr. J. Zool 1994 40 339 350
-
Baumann R., Bauer C., Rathschlag-Schaefer A.M.Causes of the postnatal decrease of blood oxygen affinity in lambs Respir. Physiol 1972 14 151 158
-
Berner N.J., Ingermann R.L.Molecular basis of the difference in oxygen affinity between maternal and foetal red blood cells in the viviparous garter snake Thamnophis elegans J. Exp. Biol 1988 140 437 453
-
Birchard G.F., Black C.P., Schuett G.W., Black V.Foetal-maternal blood respiratory properties of an ovovi viparous snake the cottonmouth, Agkistrodon piscivorus J. Exp. Biol 1984 108 247 255
-
Brittain T.A possible role for protein dissociation in the functioning of embryonic haemoglobins J. Exp. Biol 1987 127 443 447
-
Brittain T., Wells R.M.G., Oxygen transport in early mammalian development: molecular physiology of embryonic hemoglobins. Development in mammals Johnson M.H.Elsevier Science Publishers Amsterdam 1983 135 154
-
Dhindsa D.S., Metcalfe J., Blackmore D.W., Koler R.D.Postnatal changes in oxygen affinity of rat blood. Comp. Physiol. Biochem. 69 A 1981 279 283
-
Franzke R., Jelkmann W.Characterization of the pyruvate kinase which induces the low 2,3-DPG level of fetal rabbit red cells Pflügers Arch 1982 391 21 25
-
Frier J.A., Perutz M.F.Structure of human foetal deoxyhaemoglobin J. Mol. Biol 1977 112 97 112
-
Garlick R.L., Davis B.J., Farmer M., Fyhn H.J., Fyhn U.E.H., Noble R.W., Powers D.A., Riggs A., Weber R.E.A fetal-maternal shift in the oxygen equilibrium of hemoglobin from the viviparous caecilian Typhlonectes compressicauda. Comp. Biochem. Physiol. A62: 1979 239 244
-
Giardina B., Scatena R., Clementi M.E., Cerroni L., Nuutinen M., Brix O., Sletten S.N., Castagnola M., Condo S.G.Physiological relevance of the overall ΔH of oxygen binding to fetal human hemoglobin J. Mol. Biol 1993 229 512 516
-
Gilman J.G.Rat embryonic and fetal erythrocytes Biochem. J 1980 192 355359
-
Grigg G.C., Harlow P.A fetal-maternal shift of blood oxygen affinity in an Australian viviparous lizard Sphenomorphus quoyii (Reptilia, Scincidae). J. Comp. Physiol. B142: 1981 495 499
-
Hammerberg B., Brett I., Kitchen H.Ontogeny of hemoglobins in sheep Ann. N.Y. Acad. Sci 1974 241 672 682
-
Harkness D.R., Ponge J., Grayson V.A comparative study of the phosphoglyceric acid cycle in mammalian erythrocytes Comp. Biochem. Physiol 1969 28 129 138
-
Hartvig M., Weber R.E., Blood adaptations for maternal-fetal oxygen transfer in the viviparous teleost Zoarces viviparus Seymour R.S.1984 17 30L. In: Respiration and metabolism of embryonic vertebrates. Dr. W. Junk Publishers, Dordrecht
-
Holland R.A.B.Special oxygen carrying properties of embryonic blood Isr. J. Zool 1994 40 401 416
-
Holland R.A.B., Hallam J.F., Thompson M.B., Shine R., Harlow P.Oxygen carriage by blood of gravid and non-gravid adults, and in embryos and new-born, of a viviparous Australian elapid snake, Pseudechis porphyriacus Physiologist 1990 33A-68
-
Huehns E.R., Farooqui A.M.Oxygen dissociation properties of human embryonic red cells Nature 1975 254 335 337
-
Huggett A.S.G.Foetal blood gas tensions and gas transfusion through the placenta of the goat J. Physiol. (London) 1927 62 373 384
-
Ingermann R.L., Terwilliger R.C.Oxygen affinities of maternal and fetal hemoglobins of the viviparous seaperch Embiotoca lateralis. J. Comp. Physiol. B142: 1981a 523 531
-
Ingermann R.L., Terwilliger R.C.Intraerythrocytic organic phosphates of fetal and adult seaperch “Embiotoca lateralis 1981b 253 259Their role in maternal-fetal oxygen transport. J. Comp. Physiol. B144
-
Ingermann R.L., Terwilliger R.C.Blood parameters and facilitation of maternal-fetal oxygen transfer in a viviparous fish “Embiotoca lateralis. Comp. Biochem. Physiol. A73: 1982 497 501
-
Ingermann R.L., Terwilliger R.C., Facilitation of maternal-fetal oxygen transfer in fishes: Anatomical and molecular specializations. Respiration and metabolism of embryonic vertebrates. Dr. W. Junk Publishers, Dordrecht Seymour R.S.1984 1 15
-
Ingermann R.L., Berner N.J., Ragsdale F.R.Effect of pregnancy and temperature on red cell oxygen-affinity in the viviparous snake Thamnophis elegans J. Exp. Biol 1991 156 399 406
-
Jelkmann W., Bauer C.Oxygen affinity and phosphate compounds of red blood cells during intrauterine development of rabbits Pflüg. Arch 1977 372 149 156
-
Jelkmann W., Bauer C.Embryonic hemoglobins: Dependency of functional characteristics on tetramer composition Pflüg. Arch 1978 377 75 80
-
Kleinschmidt T., Sgouros J.G.Hemoglobin sequences Biol. Chem. Hoppe-Seyler 1987 368 579 615
-
Kleinschmidt T., März J., Jürgens K.D., Braunitzer G.The primary structure of two tylopod hemoglobins with high oxygen affinity: vicuna (Lama vicugna) and alpaca (Lama pacos) Biol. Chem. Hoppe-Seyler 1986 367 153 160
-
Korsgaard B., Weber R.E.Maternal-fetal trophic and respiratory relationships in viviparous ectothermic vertebrates Adv. Comp. Environ. Physiol 1989 5 209 233
-
Lestas A.N., Bellingham A.J., Nicolaides K.H.Red cell glycolytic intermediates in normal, anaemic and transfused human fetuses Br. J. Haematol 1989 73 387 391
-
Longo L.D., Respiratory gas exchange in the placenta. Handbook of physiology. Section 3. The respiratory system. Vol Fishman A.P., Farhi L.S., Tenney S.M., Geiger S.R.1987 4 351 401Gas exchange. Am. Physiol. Soc., Bethesda, MD
-
Manwell C.Ontogeny of hemoglobin in the skate Raja binoculata Science 1958 128 419 420
-
Novy M.J., Parer J.T.Absence of high blood oxygen affinity in the fetal cat Respir. Physiol 1969 6 144 150
-
Perutz M.F.Species adaptation in a protein molecule Mol. Biol. Evol 1983 1 1 28
-
Pough F.H.Ontogenetic change in molecular and functional properties of blood of garter snakes, Thamnophis sirtalis J. Exp. Zool 1977 201 47 56
-
Purdie A., Wells R.M.G., Brittain T.Molecular aspects of embryonic mouse haemoglobin ontogeny Biochem. J 1983 215 377 383
-
Qvist J., Weber R.E., Zapoll W.M.Oxygen equilibrium properties of blood and hemoglobin of fetal and adult Weddell seals J. Appl. Physiol. (Respir. Environ. Exercise Physiol.) 1981 50 999 1005
-
Ragsdale F.R., Ingermann R.L.Biochemical bases for difference in oxygen affinity of maternal and fetal red blood cells of rattlesnakes Am. J. Physiol 1993 264 R481 R486
-
Riggs A.F.The Bohr effect Annu. Rev. Physiol 1988 50 181 204
-
Shine R., Physiological and ecological questions on the evolution of reptilian viviparity. Respiration and metabolism of embryonic vertebrates Seymour R.S.Dr. W. Junk Dordrecht 1984 147 154
-
Tibben E.A., Holland R.A.B., Tyndale-Biscoe C.H.Blood oxygen carriage in the marsupial, tammar wallaby (Macropus eugenii), at prenatal and neonatal stages Respir. Physiol 1991 84 93 104
-
Tornita S.Modulation of the oxygen equilibria of human fetal and adult hemoglobins by 2,3-diphosphoglyceric acid J. Biol. Chem 1981 256 9495 9500
-
Tuchinda S., Nagai K., Lehman H.Oxygen dissociation curve of haemoglobin Portland FEBS Lett 1975 49 390 391
-
Weber R.E.1995Molecular adaptations supporting O2 transfer between adult, fetal and embryonic Hbs. In preparation
-
Weber R.E., Hartvig M.Specific fetal hemoglobin underlies the fetal-maternal shift in blood oxygen afinity in a viviparous teleost Mol. Physiol 1984 6 27 32
-
Weber R.E., Lykkeboe G.Respiratory adaptations in carp blood Influence of hypoxia, red cell organic phosphates divalent cations and CO2 on hemoglobin-oxygen affinity. J. comp. Physiol 1978 128 127 137
-
Weber R.E., Wells R.M.G., Hemoglobin structure and function. Lung biology in health and disease; comparative pulmonary physiology: current concepts, chapter 10, pp Wood S.C., Lenfant C.1989 279 310
-
Weber R.E., Wells R.M.G., Rossetti J.E.Allosteric interactions governing oxygen equilibria in the hemoglobin system of the dogfish, Squalus acanthias J. Exp. Biol 1983 103 109 120
-
Weber R.E., Kleinschmidt T., Braunitzer G.Embryonic pig hemoglobins Gower I (ζ2ε2), Gower II (α2ε2), Heide I (ζ2θ2) and Heide II (α2θ2): oxygen-binding functions related to structure and embryonic oxygen supply Respir. Physiol 1987 69 347 357
-
Weber R.E., Lalthantluanga R., Braunitzer G.Functional characterization of fetal and adult yak hemoglobins: an oxygen binding cascade and its molecular basis Arch. Biochem. Biophys 1988 263 199 203
-
Wells R.M.G.Haemoglobin-oxygen affinity in developing erythroid cells of the mouse J. Comp. Physiol 1979 129 333 338
-
Wells R.M.G., Brittain T.Transition to cooperative oxygen-binding by embryonic haemoglobin in mice J. Exp. Biol 1981 90 351 355
-
Wells R.M.G., Brittain T.Non-cooperative oxygen binding in the erythrocytes of pre-implanted sheep embryos. Comp. Biochem. Physiol. A76: 1983 387 388
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HEMOGLOBIN-BASED O2 TRANSFER IN VIVIPAROUS ANIMALS
In: Israel Journal of Ecology and EvolutionSearch for other papers by ROY E. WEBER in
Current site
Google Scholar
PubMed
The transfer of O2 from the maternal to prenatal circulation is facilitated by higher O2 affinities in prenatal blood. The affinity shifts that may compensate for lack or feeble development of placental connections result from different operating conditions for the Hb (such as lower concentrations of organic phosphates that depress Hb-O2 affinity in the fetal red cells), or the occurrence of specific fetal and embryonic Hb's that have either higher intrinsic O2 affinities than adult Hb or lower sensitivities to phosphate cofactors. The affinity shifts correlate with amino acid substitutions at very few, key positions in the Hb protein moieties and thus demonstrate conservatism in molecular strategies. The complex molecular systems encountered in early embryos may favor homeostasis in tissue O2 supply and compensate for their lower organization at the organ level compared to adults.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 173 | 28 | 10 |
| Full Text Views | 8 | 0 | 0 |
| PDF Views & Downloads | 8 | 0 | 0 |
