AMINO ACID METABOLISM DURING FETAL DEVELOPMENT
In: Israel Journal of Ecology and EvolutionSearch for other papers by FREDERICK C. BATIAGLIA in
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Fetal and placental amino acid metabolism has been studied using multiple tracer methodology. Comparisons between species have been difficult because of technical differences that make such comparisons inappropriate. However, comparisons of the metabolism of different amino acids within the same species, the fetal lamb, are now possible because of the abundance of studies carried out in this species. The role of placental metabolism in contributing to the determination of the supply of amino acids to the fetus has been better defined. Some amino acids such as glutamate are catabolized significantly within the placenta, others are transported with little placental catabolism. The organ specificity noted in adult metabolism for specific amino acids is now well established in fetal life as well. Fetal hepatic metabolism is characterized by a large uptake of most amino acids and by a net release of glutamate and serine. Amino acid uptake by the hindlimb differs significantly from postnatal life not only in the magnitude of the amino acid uptake but also by the fact that amino acids normally released from the hindlimb in postnatal life such as alanine and glutamine are taken up by these tissues in fetal life. The impact of changes in the fetal biologic state introduced by hypoxia or by undernutrition are just beginning to be investigated in terms of the flux of amino acids to protein synthesis versus catabolism and oxidation.
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Battaglia F.C., Meschia G.Fetal Nutrition Annu. Rev. Nutr 1988 8 43 61
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Bell A.W., Kennaugh J.M., Battaglia F.C., Meschia G.Uptake of amino acids and ammonia at mid-gestation by the fetal lamb Q. J. Exp. Physiol 1989 74 635 643
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Cetin I., Sparks J.W., Quick A.N. Jr., Marconi A.M., Meschia G., Battaglia F.C., Fennessey P.V.Glycine turnover and oxidation and hepatic serine synthesis from glycine in fetal lambs. Am. J. Physiol. 260 (Endo. Metab. 23): E371–E378 1991
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Cetin I., Fennessey P.V., Sparks J.W., Meschia G., Battaglia F.C.Fetal serine fluxes across the fetal liver, hindlimb and placenta in late gestation: The role of fetal serine in placenta glycine production Am. J. Physiol 1992 263 4Part 1: (Endo. Metab. 26) E786–E793
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Gresham E.L., Simons P.S., Battaglia F.C.Maternal—fetal urea concentration difference in man: metabolic significance J. Pediatr 1971 79 809 811
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Gresham E.L., James E.J., Raye J.R., Battaglia F.C., Makowski E.L., Meschia G.Production and excretion of urea by the fetal lamb Pediatrics 1972 50 372 379
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Loy G.L., Quick A.N. Jr., Hay W.W. Jr., Meschia G., Battaglia F.C., Fennessey P.V.Feto-placental deamination and decarboxylation of leucine. Am. J. Physiol. 259 (Endo. Metab.22): E492–E497 1990
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Marconi A.M., Battaglia F.C., Meschia G., Sparks J.W.A comparison of amino acid arteriovenous differences across the liver, hindlimb and placenta in the fetal lamb Am. J. Physiol 1989 257 E909 E915
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Moores R.R., Rietberg C.C., Battaglia F.C., Fennessey P.V., Meschia G.Metabolism and transport of maternal serine by the ovine placenta: Glycine production and absence of serine transport into the fetus Pediatr. Res 1993 33 6 590 594
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Smith C.H., Nelson D.M., King B.F., Donohue T.M., Ruzycki S.M., Kelley L.K.Characterization of a microvillous membrane preparation from human placental syncytiotrophoblast: A morphologic, biochemical and physiologic study Am. J. Obstet. Gynecol 1977 128 190 196
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Vaughn P.R., Battaglia F.C., Fennessey P.V., Wilkening R.B., Meschia G.The role of hepatic glutamine uptake in fetal hepatic glutamate production Pediatr. Res 1993 33 4 2April, 1993. Abstract No. 336. Presented at the APS/SPR, May 3–6, 1993
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Vaughn P.R., Lobo C., Battaglia F.C., Fennessey P.V., Wilkening R.B., Meschia G.Steady state glutamine fluxes in late gestation sheep. In preparation
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Wheeler C.P.D., Yudilevich D.L. LysineBiochim Biophys. Acta 1989 978 257 266and alanine transport in the perfused guinea-pig placenta
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Wilkening R.B., Boyle D.W., Teng C., Meschia G., Battaglia F.C.Amino acid uptake by the fetal ovine hindlimb under normal and euglycemic hyperinsulinemic states Am. J. Physiol 1994 266 E72 E78
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AMINO ACID METABOLISM DURING FETAL DEVELOPMENT
In: Israel Journal of Ecology and EvolutionSearch for other papers by FREDERICK C. BATIAGLIA in
Current site
Google Scholar
PubMed
Fetal and placental amino acid metabolism has been studied using multiple tracer methodology. Comparisons between species have been difficult because of technical differences that make such comparisons inappropriate. However, comparisons of the metabolism of different amino acids within the same species, the fetal lamb, are now possible because of the abundance of studies carried out in this species. The role of placental metabolism in contributing to the determination of the supply of amino acids to the fetus has been better defined. Some amino acids such as glutamate are catabolized significantly within the placenta, others are transported with little placental catabolism. The organ specificity noted in adult metabolism for specific amino acids is now well established in fetal life as well. Fetal hepatic metabolism is characterized by a large uptake of most amino acids and by a net release of glutamate and serine. Amino acid uptake by the hindlimb differs significantly from postnatal life not only in the magnitude of the amino acid uptake but also by the fact that amino acids normally released from the hindlimb in postnatal life such as alanine and glutamine are taken up by these tissues in fetal life. The impact of changes in the fetal biologic state introduced by hypoxia or by undernutrition are just beginning to be investigated in terms of the flux of amino acids to protein synthesis versus catabolism and oxidation.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 121 | 38 | 10 |
| Full Text Views | 9 | 0 | 0 |
| PDF Views & Downloads | 8 | 0 | 0 |
