Exercise-induced adaptations extend beyond skeletal muscle and may influence pancreatic function. Pancreatic and duodenal homeobox-1 (Pdx-1) is a key regulator of β-cell function and insulin synthesis, yet its response to different exercise modalities in diabetes remains unclear. The objective was to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on serum insulin and pancreatic Pdx-1 expression in a streptozotocin (STZ)-induced diabetic rat model. Thirty-two male Wistar rats were assigned to four groups: control, diabetes mellitus (DM), DM+MICT, and DM+HIIT. Diabetes was induced by STZ (45 mg/kg body weight). Exercise protocols were conducted on a treadmill, five days per week for six weeks. MICT involved continuous running at 60–65% maximal velocity, whereas HIIT consisted of repeated high-intensity bouts (85–90%) interspersed with recovery periods. Serum insulin was measured using ELISA, and Pdx-1 gene expression was quantified by relative qPCR. Statistical analysis was performed using one-way ANOVA with Tukey’s post hoc test. STZ-induced diabetes significantly reduced insulin levels compared to controls (
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Al-Mhanna, S.B., Poon, E.T., Franklin, B.A., Tarnopolsky, M.A., Hawley, J.A., Jakicic, J.M., Stamatakis, E., Little, J.P., Pescatello, L.S., Riebe, D., Thompson, W.R., Skinner, J.S., Colberg, S.R., Ehrman, J.K., Metsios, G.S., Douda, H.T., Omar, N., Alghannam, A.F. and Batrakoulis, A., 2025. Comparative effectiveness of high-intensity interval training and moderate-intensity continuous training on cardiometabolic health in patients with diabesity: a systematic review and meta-analysis of randomized controlled trials. Diabetology and Metabolic Syndrome 17: 331. https://doi.org/10.1186/s13098-025-01909-z
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Exercise-induced adaptations extend beyond skeletal muscle and may influence pancreatic function. Pancreatic and duodenal homeobox-1 (Pdx-1) is a key regulator of β-cell function and insulin synthesis, yet its response to different exercise modalities in diabetes remains unclear. The objective was to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on serum insulin and pancreatic Pdx-1 expression in a streptozotocin (STZ)-induced diabetic rat model. Thirty-two male Wistar rats were assigned to four groups: control, diabetes mellitus (DM), DM+MICT, and DM+HIIT. Diabetes was induced by STZ (45 mg/kg body weight). Exercise protocols were conducted on a treadmill, five days per week for six weeks. MICT involved continuous running at 60–65% maximal velocity, whereas HIIT consisted of repeated high-intensity bouts (85–90%) interspersed with recovery periods. Serum insulin was measured using ELISA, and Pdx-1 gene expression was quantified by relative qPCR. Statistical analysis was performed using one-way ANOVA with Tukey’s post hoc test. STZ-induced diabetes significantly reduced insulin levels compared to controls (
| 全部期间 | 过去一年 | 过去30天 | |
|---|---|---|---|
| 摘要浏览次数 | 45 | 45 | 45 |
| 全文浏览次数 | 1 | 1 | 1 |
| PDF下载次数 | 1 | 1 | 1 |