Effect of physical exercise on kidney function and fibrotic markers in L-NAME-induced hypertensive rats
In: Comparative Exercise PhysiologyDepartment of Medical Physiology, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, South Tangerang, Indonesia
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Abstract
Hypertension may develop into kidney damage which can lead to kidney fibrosis. Regular physical activity provides an effective strategy for managing blood pressure by stimulating the release of nitric oxide to induce vasodilation. Although high-intensity interval training (HIIT) and moderate intensity continuous training (MICT) have emerged as widely used exercise strategies for lowering blood pressure, their comparative impact on kidney in hypertensive conditions remain unclear. This study aimed to determine the effects of HIIT and MICT on creatinine, urea, CTGF levels and collagen deposition in NG-Nitro-L-Arginine Methyl Ester (L-NAME) induced hypertensive rats. This was an experimental study using twenty-four male Wistar rats were divided into 4 groups: control, L-NAME, L-NAME + HIIT, and L-NAME + MICT. All rats except control group was given L-NAME 40 mg/kg/day orally once a day for 5 weeks. Rats in exercise groups were given exercise for five days per week for five weeks. We found that L-NAME + HIIT had lower creatinine and urea levels compared to L-NAME (
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Effect of physical exercise on kidney function and fibrotic markers in L-NAME-induced hypertensive rats
In: Comparative Exercise PhysiologyDepartment of Medical Physiology, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, South Tangerang, Indonesia
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Center for Sport and Exercise Sciences, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
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Abstract
Hypertension may develop into kidney damage which can lead to kidney fibrosis. Regular physical activity provides an effective strategy for managing blood pressure by stimulating the release of nitric oxide to induce vasodilation. Although high-intensity interval training (HIIT) and moderate intensity continuous training (MICT) have emerged as widely used exercise strategies for lowering blood pressure, their comparative impact on kidney in hypertensive conditions remain unclear. This study aimed to determine the effects of HIIT and MICT on creatinine, urea, CTGF levels and collagen deposition in NG-Nitro-L-Arginine Methyl Ester (L-NAME) induced hypertensive rats. This was an experimental study using twenty-four male Wistar rats were divided into 4 groups: control, L-NAME, L-NAME + HIIT, and L-NAME + MICT. All rats except control group was given L-NAME 40 mg/kg/day orally once a day for 5 weeks. Rats in exercise groups were given exercise for five days per week for five weeks. We found that L-NAME + HIIT had lower creatinine and urea levels compared to L-NAME (
| All Time | Past 365 days | Past 30 Days | |
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