Swimming and strength exercise improve clinical abnormalities of mice with experimental autoimmune encephalomyelitis by modulating key neuroimmunological pathways
In: Comparative Exercise PhysiologySearch for other papers by S.E. Andani in
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Department of Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
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Abstract
Experimental autoimmune encephalomyelitis (EAE) affects the Ido1-Ahr-Odc1 signaling axis, which has been identified as a potential treatment endpoint in EAE. This study aimed to compare the effects of different exercise regimens on this axis in the cerebellum of EAE mice. Forty mice were divided into four groups: (1) healthy controls, (2) mice with EAE, (3) EAE mice treated with swimming exercise, and (4) EAE mice treated with strength exercise. Mice were subjected to two distinct exercise interventions for 30 min/day, 5 days/week, over 4 weeks. Quantitative gene expression analysis of indoleamine 2, 3-dioxygenase 1 (Ido1), aryl hydrocarbon receptor (Ahr), ornithine decarboxylase 1 (Odc1), spermidine synthetase (Spds), and arylalkylamine N-acetyltransferase (Aanat) was performed using RT-PCR. Clinical signs and body weight were recorded daily in all mice. Motor performance was evaluated using the rotarod test. Results showed significant changes in the expression of Ido1 (F = 77.08,
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Swimming and strength exercise improve clinical abnormalities of mice with experimental autoimmune encephalomyelitis by modulating key neuroimmunological pathways
In: Comparative Exercise PhysiologySearch for other papers by S.E. Andani in
Current site
Google Scholar
PubMed
Search for other papers by S. Shahrbanian in
Current site
Google Scholar
PubMed
Search for other papers by M.R. Kordi in
Current site
Google Scholar
PubMed
Department of Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
Search for other papers by M.M. Shamsi in
Current site
Google Scholar
PubMed
Abstract
Experimental autoimmune encephalomyelitis (EAE) affects the Ido1-Ahr-Odc1 signaling axis, which has been identified as a potential treatment endpoint in EAE. This study aimed to compare the effects of different exercise regimens on this axis in the cerebellum of EAE mice. Forty mice were divided into four groups: (1) healthy controls, (2) mice with EAE, (3) EAE mice treated with swimming exercise, and (4) EAE mice treated with strength exercise. Mice were subjected to two distinct exercise interventions for 30 min/day, 5 days/week, over 4 weeks. Quantitative gene expression analysis of indoleamine 2, 3-dioxygenase 1 (Ido1), aryl hydrocarbon receptor (Ahr), ornithine decarboxylase 1 (Odc1), spermidine synthetase (Spds), and arylalkylamine N-acetyltransferase (Aanat) was performed using RT-PCR. Clinical signs and body weight were recorded daily in all mice. Motor performance was evaluated using the rotarod test. Results showed significant changes in the expression of Ido1 (F = 77.08,
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 55 | 55 | 30 |
| Full Text Views | 2 | 2 | 1 |
| PDF Views & Downloads | 5 | 5 | 2 |
