Exercise-induced modulation of thyroid and lipid physiology following high-intensity interval training in adults with subclinical hypothyroidism: a pilot study
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Abstract
Subclinical hypothyroidism (SCH) is associated with alterations in thyroid regulation and lipid metabolism. High-intensity interval training (HIIT) is a potent physiological stimulus known to influence endocrine and metabolic pathways, yet its effects on thyroid-lipid interactions in SCH remain inadequately explored the objective is to evaluate the physiological responses of thyroid-stimulating hormone (TSH) and lipid profile parameters following an eight-week supervised HIIT intervention in adults with SCH and to assess the feasibility of implementing this exercise protocol. Fifteen adults with SCH (TSH 4.5-10 mIU/l) participated in an eight-week supervised HIIT program (three sessions/week). Pre- and post-intervention assessments included serum TSH, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels. Feasibility outcomes included recruitment rate, session adherence, retention, adverse events, and acceptability. All eligible participants consented to participate, with 100% retention and mean session adherence of 88-92%. No major adverse events were reported. Within-group analysis demonstrated a significant reduction in TSH levels (
The trial was prospectively registered with the Clinical Trials Registry-India (CTRI) under the registration number CTRI/2025/04/084460.
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Exercise-induced modulation of thyroid and lipid physiology following high-intensity interval training in adults with subclinical hypothyroidism: a pilot study
In: Comparative Exercise PhysiologySearch for other papers by S. Hulamani in
Current site
Google Scholar
PubMed
Search for other papers by V. Kage in
Current site
Google Scholar
PubMed
Search for other papers by V. Ghatnatti in
Current site
Google Scholar
PubMed
Abstract
Subclinical hypothyroidism (SCH) is associated with alterations in thyroid regulation and lipid metabolism. High-intensity interval training (HIIT) is a potent physiological stimulus known to influence endocrine and metabolic pathways, yet its effects on thyroid-lipid interactions in SCH remain inadequately explored the objective is to evaluate the physiological responses of thyroid-stimulating hormone (TSH) and lipid profile parameters following an eight-week supervised HIIT intervention in adults with SCH and to assess the feasibility of implementing this exercise protocol. Fifteen adults with SCH (TSH 4.5-10 mIU/l) participated in an eight-week supervised HIIT program (three sessions/week). Pre- and post-intervention assessments included serum TSH, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels. Feasibility outcomes included recruitment rate, session adherence, retention, adverse events, and acceptability. All eligible participants consented to participate, with 100% retention and mean session adherence of 88-92%. No major adverse events were reported. Within-group analysis demonstrated a significant reduction in TSH levels (
The trial was prospectively registered with the Clinical Trials Registry-India (CTRI) under the registration number CTRI/2025/04/084460.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 135 | 135 | 75 |
| Full Text Views | 1 | 1 | 0 |
| PDF Views & Downloads | 3 | 3 | 0 |
