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Capsaicin (CAP) as an anti-obesity drug plays a role in the treatment of many diseases. The purpose of this study was to investigate the effect of CAP with or without circuit resistance training (CRT) on physical fitness, lipid profile and liver enzymes in obese women. Forty-four obese female participants ages 24-35 years (Mage = 31.1 years) were randomized into four groups: placebo (PLA), CAP, training+placebo (TRA+PLA), and training+capsaicin (TRA+CAP). The daily CAP supplement was 2.5 mg, administered as two 500 mg red pepper capsules per day for 8 weeks. CRT consisted of 8 weeks, 3 sessions per week and 45-60 min each session. The body mass index (BMI), body fat percentage, waist-to-hip ratio (WHR), bench press strength, leg press strength, bench press endurance, leg press endurance, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were analysed pre- and post-training. A significant improvement in all measured variables except WHR in the TRA+CAP group (
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Al-Khudairy, L., Loveman, E., Colquitt, J.L., Mead, E., Johnson, R.E., Fraser, H., Olajide, J., Murphy, M., Velho, R.M., O’Malley, C., Azevedo, L.B., Ells, L.J., Metzendorf, M.I. and Rees, K., 2017. Diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to 17 years. Cochrane Database of Systematic Reviews 6(6): CD012691. https://doi.org/10.1002/14651858.CD012691
Amirkhani, Z., Azarbayjani, M.A., Homaei, H.M. and Peeri, M., 2016. Effect of combining resistance training and curcumin supplementation on liver enzyme in inactive obese and overweight females. Iranian Journal of Diabetes and Obesity 8(3): 107-114. Retrieved from https://ijdo.ssu.ac.ir/files/site1/user_files_b889fb/eng/najafi-A-10-30-146-dc85729.pdf
Azmand, F., Haghighi, A.H., Askari, R. and Shahrabadi, H., 2024. The effect of concurrent training on some cardiovascular risk factors, serum estradiol and physical fitness indicators in overweight women with type 2 diabetes. Iranian Journal of Health Sciences 12(1): 59-68.
Bae, J.Y., 2020. Resistance exercise regulates hepatic lipolytic factors as effective as aerobic exercise in obese mice. International Journal of Environmental Research and Public Health 17(22): 8307. https://doi.org/10.3390/ijerph17228307
Bort, A., Sánchez, B.G., Mateos-Gómez, P.A., Dı́az-Laviada, I. and Rodrı́guez-Henche, N., 2019. Capsaicin targets lipogenesis in HepG2 cells through AMPK activation, AKT inhibition and PPARs regulation. International Journal of Molecular Sciences 20(7): 1660. https://doi.org/10.3390/ijms20071660
Clemons, J.M., Duncan, C.A., Blanchard, O.E., Gatch, W.H., Hollander, D.B. and Doucet, J.L., 2004. Relationships between the flexed-arm hang and select measures of muscular fitness. Journal of Strength and Conditioning Research 18(3): 630-636. https://doi.org/10.1519/R-12342.1
Cohen, J., 1988. Statistical power analysis for the behavioural science. 2nd ed. Lawrence Erlbaum Associates, Hilldale, NJ, USA.
Cross, B.L., Parker, D., Langan, S.P. and Grosicki, G.J., 2020. Effect of a commercially available low-dose capsaicin supplement on knee extensor contractile function. International Journal of Exercise Science 13(2): 312-318.
Ding, C. and Jiang, Y., 2020. The relationship between body mass index and physical fitness among Chinese university students: results of a longitudinal study. Healthcare 8(4): 570. https://doi.org/10.3390/healthcare8040570
Do Nascimento, M.A., Cyrino, E.S., Nakamura, F.Y., Romanzini, M., Pianca, H.J.C. and Queiróga, M.R., 2007. Validation of the Brzycki equation for the estimation of 1-RM in the bench press. Revista Brasileira de Medicina Do Esporte 13: 47-50.
Ebrahimi, S., Shiraseb, F., Ladaninezhad, M., Navaei, N., Izadi, A. and Mirzaei, K., 2025. The association between lifestyle risk score and mental health in Iranian overweight and obese women: A cross-sectional study. Frontiers in Nutrition 12: 1533453. https://doi.org/10.3389/fnut.2025.1533453
Giuriato, G., Venturelli, M., Matias, A., Soares, E.M.K.V.K., Gaetgens, J., Frederick, K.A. and Ives, S.J., 2022. Capsaicin and its effect on exercise performance, fatigue and inflammation after exercise. Nutrients 14(2): 232. https://doi.org/10.3390/nu14020232
Hsu, Y.-J., Huang, W.-C., Chiu, C.-C., Liu, Y.-L., Chiu, W.-C., Chiu, C.-H. and Huang, C.-C., 2016. Capsaicin supplementation reduces physical fatigue and improves exercise performance in mice. Nutrients 8(10): 648. https://doi.org/10.3390/nu8100648
Hudwan, H., Pourvaghar, M.J. and Bahram, M.E., 2024. The effect of 8 weeks of intense resistance training on serum levels of perpetin, atropine and insulin hormone in obese men with prediabetes. Journal of Applied Health Studies in Sport Physiology. Available at: http://jahssp.azaruniv.ac.ir/article_14727_en.html?lang=fa
Hussain, A., Ali, I., Kaleem, W.A. and Yasmeen, F., 2019. Correlation between body mass index and lipid profile in patients with type 2 diabetes attending a tertiary care hospital in Peshawar. Pakistan Journal of Medical Sciences 35(3): 591-597. https://doi.org/10.12669/pjms.35.3.7
Jackson, A.S. and Pollock, M.L., 1985. Practical assessment of body composition. Physician and Sports Medicine 13(5): 76-90. https://doi.org/10.1080/00913847.1985.11708790
Jiang, Z., Qu, H., Lin, G., Shi, D., Chen, K. and Gao, Z., 2022. Lipid-lowering efficacy of the capsaicin in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Nutrition 9: 812294. https://doi.org/10.3389/fnut.2022.812294
Jin, X., Qiu, T., Li, L., Yu, R., Chen, X., Li, C., Proud, C.G. and Jiang, T., 2023. Pathophysiology of obesity and its associated diseases. Acta Pharmaceutica Sinica. B 13(6): 2403-2424. https://doi.org/10.1016/j.apsb.2023.01.012
Joseph, A., John, F., Thomas, J.V., Sivadasan, S.D.P., Maliakel, B., Mohan, R. and Im, K., 2021. Influence of a novel food-grade formulation of red chili extract (Capsicum annum) on overweight subjects: randomized, double-blinded, placebo-controlled study. Journal of Dietary Supplements 18(4): 387-405. https://doi.org/10.1080/19390211.2020.1780363
Kang, S., Park, K.-M., Sung, K.-Y., Yuan, Y. and Lim, S.-T., 2021. Effect of resistance exercise on the lipolysis pathway in obese pre- and postmenopausal women. Journal of Personalized Medicine 11(9): 874. https://doi.org/10.3390/jpm11090874
Kiani, N., Keshavarz, S., Hosseini, S.A. and Banai, J., 2022. The effect of resistance training with tribulus terrestris on liver enzymes in rats exposed to stanozolol. International Journal of Basic Science in Medicine 7(4): 173-178.
Kolahdouzi, S., Baghadam, M., Kani-Golzar, F.A., Saeidi, A., Jabbour, G., Ayadi, A., De Sousa, M., Zouita, A., Abderrahmane, A.B. and Zouhal, H., 2019. Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men. Physiology and Behavior 205: 15-21. https://doi.org/10.1016/j.physbeh.2018.11.033
Laine, S., Sjöros, T., Vähä-Ypyä, H., Garthwaite, T., Löyttyniemi, E., Sievänen, H., Vasankari, T., Knuuti, J. and Heinonen, I.H.A., 2021. Body adiposity, but not elements of objectively measured sedentary behavior or physical activity, is associated with circulating liver enzymes in adults with overweight and obesity. Frontiers in Endocrinology 12: 655756. https://doi.org/10.3389/fendo.2021.655756
Lee, E.-D., Seo, T.-B. and Kim, Y.-P., 2022a. Effect of resistance circuit training on health-related physical fitness, plasma lipid, and adiponectin in obese college students. Journal of Exercise Rehabilitation 18(6): 382-388. https://doi.org/10.12965/jer.2244402.201
Lee, J.-H., Kim, S.-Y. and Kim, D.-I., 2022b. Association of muscle strength and body mass index with risk factors for metabolic syndrome and its prevalence in Korean adult women. BMC Public Health 22(1): 2060. https://doi.org/10.1186/s12889-022-14520-y
Maiorana, A., O’Driscoll, G., Cheetham, C., Collis, J., Goodman, C., Rankin, S., Taylor, R. and Green, D., 2000. Combined aerobic and resistance exercise training improves functional capacity and strength in CHF. Journal of Applied Physiology 88(5): 1565-1570. https://doi.org/10.1152/jappl.2000.88.5.1565
Martı́nez-Aceviz, Y., Sobrevilla-Navarro, A.A. and Ramos-Lopez, O., 2023. Dietary intake of capsaicin and its association with markers of body adiposity and fatty liver in a Mexican adult population of Tijuana. Healthcare 11(22): 3001. https://doi.org/10.3390/healthcare11223001
Moradi Kelardeh, B., Rahmati-Ahmadabad, S., Farzanegi, P., Helalizadeh, M. and Azarbayjani, M.-A., 2020. Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease. Journal of Bodywork and Movement Therapies 24(3): 154-160. https://doi.org/10.1016/j.jbmt.2020.02.021
Moradian, H., Hossein Pour Delavar, S. and Zabet, A., 2022. The effects of eight weeks circuit resistance training on interleukin-1β, TNF-α and blood pressure in pre-hypertensive obese women. Journal of Sport Biosciences 14(1): 67-84.
Moyana, T.N., 2024. Metabolic dysfunction-associated steatotic liver disease: The question of long-term high-normal alanine aminotransferase as a screening test. World Journal of Gastroenterology 30(42): 4576-4582. https://doi.org/10.3748/wjg.v30.i42.4576
Ortega-Loubon, C., Fernández-Molina, M., Singh, G. and Correa, R., 2019. Obesity and its cardiovascular effects. Diabetes/Metabolism Research and Reviews 35(4): e3135. https://doi.org/10.1002/dmrr.3135
Qin, Y., Ran, L., Wang, J., Yu, L., Lang, H.-D., Wang, X.-L., Mi, M.T. and Zhu, J.-D., 2017. Capsaicin supplementation improved risk factors of coronary heart disease in individuals with low HDL-C levels. Nutrients 9(9): 1037. https://doi.org/10.3390/nu9091037
Ramos-Campo, D.J., Andreu Caravaca, L., Martı́nez-Rodrı́guez, A. and Rubio-Arias, J.Á., 2021. Effects of resistance circuit-based training on body composition, strength and cardiorespiratory fitness: a systematic review and meta-analysis. Biology 10(5): 377. https://doi.org/10.3390/biology10050377
Rashidkhani, B., Shahneshin, M., Rafat, R., Omidvar, N., Hoshiar, R.A., Rezazadeh, A., Ramezani, A., Hosseini, Z. and Behruz, M., 2011. Validity and reproducibility of a food frequency questionnaire for assessing dietary patterns in 18-45 years old women supported by health care in the north and east of Tehran. Iranian Journal of Endocrinology and Metabolism 13(1): 58-66.
Shen, W., Shen, M., Zhao, X., Zhu, H., Yang, Y., Lu, S., Tan, Y., Li, G., Li, M., Wang, J., Hu, F. and Le, S., 2017. Anti-obesity effect of capsaicin in mice fed with high-fat diet is associated with an increase in population of the gut bacterium Akkermansia muciniphila. Frontiers in Microbiology 8: 272. https://doi.org/10.3389/fmicb.2017.00272
Sizoo, D., de Heide, L.J.M., Emous, M., van Zutphen, T., Navis, G. and van Beek, A.P., 2021. Measuring muscle mass and strength in obesity: a review of various methods. Obesity Surgery 31(1): 384-393. https://doi.org/10.1007/s11695-020-05082-2
Smart, N.A., King, N., McFarlane, J.R., Graham, P.L. and Dieberg, G., 2018. Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: A systematic review and meta-analysis. British Journal of Sports Medicine 52(13): 834-843. https://doi.org/10.1136/bjsports-2016-096197
Tanrıkulu-Küçük, S., Başaran-Küçükgergin, C., Söğüt, İ., Tunçdemir, M., Doğru-Abbasoğlu, S., Seyithanoğlu, M., Koçak, H. and Öner-İyidoğan, Y., 2019. Dietary curcumin and capsaicin: Relationship with hepatic oxidative stress and apoptosis in rats fed a high fat diet. Advances in Clinical and Experimental Medicine 28(8): 1013-1020. https://doi.org/10.17219/acem/94145
Van Son, K.C., Te Nijenhuis-Noort, L.C., Boone, S.C., Mook-Kanamori, D.O., Holleboom, A.G., Roos, P.R., Lamb, H.J., Alblas, G., Coenraad, M.J., Rosendaal, F.R., de Mutsert, R. and Tushuizen, M.E., 2024. Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in a middle-aged population with overweight and normal liver enzymes, and diagnostic accuracy of noninvasive proxies. Medicine 103(1): e34934. https://doi.org/10.1097/MD.0000000000034934
Wang, J., Lang, H., Yu, L., Wang, L., Qin, Y. and Mi, M., 2016. Effect of dietary capsaicin consumption on body composition in overweight and obese adults. Journal of Third Military Medical University 38(14): 1701-1704. Available at: https://www.cabidigitallibrary.org/doi/full/10.5555/20163312997
Yanai, H., Adachi, H., Hakoshima, M., Iida, S. and Katsuyama, H., 2023. Metabolic-dysfunction-associated steatotic liver disease-its pathophysiology, association with atherosclerosis and cardiovascular disease, and treatments. International Journal of Molecular Sciences 24(20): 15473. https://doi.org/10.3390/ijms242015473
Yang, S., Liu, L., Meng, L. and Hu, X., 2019. Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet. Chemico-Biological Interactions 297: 1-7. https://doi.org/10.1016/j.cbi.2018.10.006
Yu, F.-X., Teng, Y.-Y., Zhu, Q.-D., Zhang, Q.-Y. and Tang, Y.-H., 2014. Inhibitory effects of capsaicin on hepatic stellate cells and liver fibrosis. Biochemistry and Cell Biology 92(5): 406-412. https://doi.org/10.1139/bcb-2014-0036
Zhang, W., Zhang, Q., Wang, L., Zhou, Q., Wang, P., Qing, Y. and Sun, C., 2023. The effects of capsaicin intake on weight loss among overweight and obese subjects: A systematic review and meta-analysis of randomised controlled trials. British Journal of Nutrition 130(9): 1645-1656. https://doi.org/10.1017/S0007114523000697
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
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Capsaicin (CAP) as an anti-obesity drug plays a role in the treatment of many diseases. The purpose of this study was to investigate the effect of CAP with or without circuit resistance training (CRT) on physical fitness, lipid profile and liver enzymes in obese women. Forty-four obese female participants ages 24-35 years (Mage = 31.1 years) were randomized into four groups: placebo (PLA), CAP, training+placebo (TRA+PLA), and training+capsaicin (TRA+CAP). The daily CAP supplement was 2.5 mg, administered as two 500 mg red pepper capsules per day for 8 weeks. CRT consisted of 8 weeks, 3 sessions per week and 45-60 min each session. The body mass index (BMI), body fat percentage, waist-to-hip ratio (WHR), bench press strength, leg press strength, bench press endurance, leg press endurance, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were analysed pre- and post-training. A significant improvement in all measured variables except WHR in the TRA+CAP group (
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 111 | 111 | 78 |
| Gesamttextansichten | 0 | 0 | 0 |
| PDF-Downloads | 0 | 0 | 0 |