High-intensity interval training and nanocurcumin consumption regulate inflammation via the adiponectin-AMPK-P53 axis in overweight/obese women
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Abstract
Obesity-induced chronic inflammation is linked to dysregulation of the adiponectin-AMPK-p53 axis and plays a critical role in metabolic diseases pathogenesis. This study investigated the effects of high-intensity interval training (HIIT) and nanocurcumin supplementation on inflammatory status through this axis in overweight/obese women. 40 overweight/obese women (BMI > 30 kg/m2) were allocated to five groups: control, HIIT, nanocurcumin supplementation (NanoC), HIIT + NanoC, and placebo. The HIIT groups ran on an ergometer three times a week for eight weeks. The NanoC groups received 80 mg/kg of nanocurcumin during these 8 weeks, consisting of training intervals at 80% of maximum heart rate (HRmax) and active recovery between intervals at 60% of HRmax. Serum levels of adiponectin, 5′-adenosine monophosphate-activated protein kinase (AMPK), p53, and interleukin (IL)-6 were measured pre- and post-intervention and statistically analysed using two-way ANOVA test. Before and after the intervention, adiponectin and AMPK levels significantly increased, while p53 and IL-6 levels significantly decreased in the HIIT, NanoC, and HIIT + NanoC groups (
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High-intensity interval training and nanocurcumin consumption regulate inflammation via the adiponectin-AMPK-P53 axis in overweight/obese women
In: Comparative Exercise PhysiologySearch for other papers by T. Babaei in
Current site
Google Scholar
PubMed
Search for other papers by K. Mohamadzadeh Salamat in
Current site
Google Scholar
PubMed
Search for other papers by Z. Etemad in
Current site
Google Scholar
PubMed
Abstract
Obesity-induced chronic inflammation is linked to dysregulation of the adiponectin-AMPK-p53 axis and plays a critical role in metabolic diseases pathogenesis. This study investigated the effects of high-intensity interval training (HIIT) and nanocurcumin supplementation on inflammatory status through this axis in overweight/obese women. 40 overweight/obese women (BMI > 30 kg/m2) were allocated to five groups: control, HIIT, nanocurcumin supplementation (NanoC), HIIT + NanoC, and placebo. The HIIT groups ran on an ergometer three times a week for eight weeks. The NanoC groups received 80 mg/kg of nanocurcumin during these 8 weeks, consisting of training intervals at 80% of maximum heart rate (HRmax) and active recovery between intervals at 60% of HRmax. Serum levels of adiponectin, 5′-adenosine monophosphate-activated protein kinase (AMPK), p53, and interleukin (IL)-6 were measured pre- and post-intervention and statistically analysed using two-way ANOVA test. Before and after the intervention, adiponectin and AMPK levels significantly increased, while p53 and IL-6 levels significantly decreased in the HIIT, NanoC, and HIIT + NanoC groups (
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 147 | 147 | 74 |
| Full Text Views | 3 | 3 | 0 |
| PDF Views & Downloads | 8 | 8 | 0 |
