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High-intensity interval training and nanocurcumin consumption regulate inflammation via the adiponectin-AMPK-P53 axis in overweight/obese women

in Comparative Exercise Physiology
Autor:innen:
T. Babaei Physical Education and Sport Sciences, Sa.C, Islamic Azad University, Sanandaj, Iran

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K. Mohamadzadeh Salamat Physical Education and Sport Sciences, Sa.C, Islamic Azad University, Sanandaj, Iran

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https://orcid.org/0000-0001-6327-0516
, und
Z. Etemad Physical Education and Sport Sciences, Sa.C, Islamic Azad University, Sanandaj, Iran

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https://orcid.org/0000-0001-5109-9571
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Abstract

Obesity-induced chronic inflammation is linked to dysregulation of the adiponectin-AMPK-p53 axis and plays a critical role in metabolic diseases pathogenesis. This study investigated the effects of high-intensity interval training (HIIT) and nanocurcumin supplementation on inflammatory status through this axis in overweight/obese women. 40 overweight/obese women (BMI > 30 kg/m2) were allocated to five groups: control, HIIT, nanocurcumin supplementation (NanoC), HIIT + NanoC, and placebo. The HIIT groups ran on an ergometer three times a week for eight weeks. The NanoC groups received 80 mg/kg of nanocurcumin during these 8 weeks, consisting of training intervals at 80% of maximum heart rate (HRmax) and active recovery between intervals at 60% of HRmax. Serum levels of adiponectin, 5′-adenosine monophosphate-activated protein kinase (AMPK), p53, and interleukin (IL)-6 were measured pre- and post-intervention and statistically analysed using two-way ANOVA test. Before and after the intervention, adiponectin and AMPK levels significantly increased, while p53 and IL-6 levels significantly decreased in the HIIT, NanoC, and HIIT + NanoC groups ( P < 0.05). The HIIT + NanoC group showed greater improvements than NanoC alone in adiponectin ( P < 0.001), AMPK ( P = 0.003), and IL-6 reduction (p = 0.045), and greater IL-6 reduction than HIIT alone ( P = 0.042). Adiponectin also differed significantly between HIIT and NanoC ( P = 0.027). The numerical trends indicated a potential greater benefit in the combination group, but the study lacked the power to confirm statistically significant synergy. The combination of HIIT and nanocurcumin supplementation significantly modulates inflammatory responses through the enhancement of the adiponectin-AMPK-p53 axis in overweight/obese women. These findings support the potential of this non-pharmacological approach for the prevention or management of obesity-related metabolic diseases and warrant further investigation in larger trials.

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